Abstract
Contrast enhancement of two different NMR contrast agents, GdDTPA and MnTPPS, was compared. Sequential recording ofT 1-weighted images at 50s intervals allowed the observation of the temporal and spatial evolution of the contrast effect in rats with glioma implanted into the right brain hemisphere. The maximum signal intensity ratio of tumour over contralateral striatum was 1.80±0.10 for GdDTPA and 1.61±0.15 for MnTPPS. The enhancement was maximal 3min after application of GdDTPA and fell rapidly to reach half maximum after 24 min. MnTPPS led to maximum tumour enhancement within 11 min and did not return to control level within the observation period (150 min). In the peritumoural edema, an enhancement effect was absent for MnTPPS, but GdDTPA spread out from the tumour resulting in a delayed but strong enhancement outside the tumour. Thus, GdDTPA, as a blood-brain-barrier tracer, led only to a transient contrast enhancement between tumour and surrounding tissue and no unambiguous demarcation of the tumour against peritumoural edema. Application of MnTPPS resulted in a long-lasting strong tumour enhancement and reliable delineation from peritumoural edema.
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Schörner W, Laniado M, Kornmesser W and Felix R (1989)Neuroradiology 31 140–147.
Schubeus P, Schörner W and Haustein J (1991)Magn Reson Med 22 249–254.
Healy ME, Hesselink JR, Press GA and Middleton MS (1987)Radiology 165 619–624.
Policard A (1924)CR Soc Biol (Paris)91 1423–1424.
Tsutsui M, Carrano CJ and Tsutsui EA (1975)Ann NY Acad Sci 244 674–684.
Winkelman J (1962)Cancer Res 22 589–596.
Nelson JA, Schmiedl U and Shankland EG (1990)Invest Radiol 25 71–73.
Chen CW, Cohen JS, Myers CE and Sohn M (1984)FEBS Lett 168 70–74.
Bockhorst K, Hoehn-Berlage M, Kocher M and Hossmann K-A (1990)Magn Reson Imag 8 499–504.
Wilmes LJ, Hoehn-Berlage M, Els T, Bockhorst K, Eis M, Bonnekoh P and Hossmann K-A (1993)J Magn Reson Imag 3 5–12.
Hoehn-Berlage M, Norris D, Bockhorst K, Ernestus R-I, Kloiber O, Bonnekoh P, Leibfritz D and Hossmann K-A (1992)Magn Reson Med 27 201–213.
Tofts PS and Kermode AG (1991)Magn Reson Med 17 357–367.
Kenney J, Schmiedl U, Maravilla K, Starr F, Graham M, Spence A and Nelson J (1992)Magn Reson Med 27 68–75.
Brant-Zawadzki M, Berry I, Osaki L and Brasch R (1986)Contrast agents in magnetic resonance imaging (Runge VM, Claussen C, Felix R and James AE Eds) pp. 118–120. Excerpta medica Amsterdam.
Hossmann K-A, Hürter T and Oschlies U (1983)Ada Neuropathol (Berlin)60 223–231.
Bockhorst K, Hoehn-Berlage M, Ernestus R-I, Tolxdorff T and Hossmann K-A (1993)Magn Reson Imag 11(5): 655–663.
Lyon RC, Faustino PJ, Cohen JS, Katz A, Mornex F, Colcher D, Baglin C, Koenig SH and Hambright P (1987)Magn Reson Med 4 24–33.
Ernestus R-I, Wilmes LJ and Hoehn-Berlage M (1992)Clinical & Experimental Metastasis 10 345–350.
Eis M, Hoehn-Berlage M, Bockhorst K and Hossmann K-A (1991) InBook of abstracts: Tenth Annual Meeting of the Society of Magnetic Resonance in Medicine. Berkeley, CA: p. 701.
Weinmann HJ (1986) Chelated contrast agents. In:Contrast agents in magnetic resonance imaging (Runge VM, Claussen C, Felix R, James AE Eds) pp. 111–113. Excerpta medica Amsterdam.
Schörner W, Felix R, Laniado M, Lange M, Weinmann HJ, Claussen C, Fiegler W, Speck U and Kazner E (1984)Fortschr Röntgenstr 140 493–500.
Brasch RC (1983)Radiology 147 781–788.
Weinmann HJ, Brasch RC, Press WE and Wesbey GE (1984)Amer J Roentgenol 142 619–624.
Carr DH, Brown J, Bydder GM, Weinmann HJ, Speck U, Thomas DJ and Young IR (1984)Lancet 1 484–486.
Felix R, Schörner W, Laniado M, Niendorf HP, Claussen C, Fiegler W and Speck U (1985)Radiology 156 681–688.
Verma A, Nye JS and Snyder SH (1987)Proc Natl Acad Sci USA 84 2256–2260.
Snyder SH, Verma A and Trifiletti RR (1987)FASEB J 1 282–288.
Ikezaki K, Nomura T, Takahashi M, Fritz-Zieroth B and Fukui M (1993)Acta Neurochirur. in press.
Gal D, MacDonald PC, Porter JC and Simpson ER (1981)Int J Cancer 28 315–319.
Maziere JC, Santus R, Morliere P, Reyftmann JP, Candide C, Mora L, Salmon S, Maziere C, Gatt S and Dubertret L (1990)J Photochem Photobiol B 6 61–68.
Morliere P, Momenteau M, Candide C, Simonin V, Santus R, Maziere JC, Dubertret L, Goldstein S and Hüppe G (1990)J Photochem Photobiol B 5 49–67.
Maziere JC, Morliere P and Santus RJ (1991)J Photochem Photobiol B 8 351–360.
Ogan MD, Revel D and Brasch RC (1987)Invest Radiol 22 822–828.
Hambright P (1977)J Inorg Chem 39 1102.
Ito U, Reulen H-J and Huber P (1986)Ada Neurochir. 81 53–60.
Reulen H-J, Graber S, Huber P and Ito U (1988)Ada Neurochir. (Wien) 95 19–24.
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Els, T., Bockhorst, K. & Hoehn-berlage, M. Nmr contrast enhancement of brain tumours: comparison of the blood brain barrier tracer GdDTPA and the tumour-selective contrast agent MnTPPS. MAGMA 1, 126–133 (1993). https://doi.org/10.1007/BF01769414
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DOI: https://doi.org/10.1007/BF01769414