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31P-NMR spectroscopy of human blood and serum: first results from volunteers and patients with congestive heart failure, diabetes mellitus and hyperlipidaemia

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Abstract

31P-containing metabolites in human blood, serum and erythrocytes were measured or calculated. Phosphodiesters were found in serum, but not in erythrocytes. 2,3-diphosphoglycerate and 2,3-diphosphoglycerate/ATP ratios were increased in patients with congestive heart failure (2,3-diphosphoglycerate by 13% in mild to moderate, 31% in severe congestive heart failure, 2,3-diphosphoglycerate/ATP ratio by 9% in mild to moderate, 38% in severe congestive heart failure); phosphodiesters were increased in diabetes mellitus (by 26%) and even more so in hyperlipidaemia (by 57%). Changes of blood31P compounds with disease states may have diagnostic potential and should be recognized for correction of organ spectra.

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References

  1. Brewer GJ (1974) InThe Red Blood Cell, vol 1, (D. MacN Surgenor ed) p. 394. New York, Academic Press.

    Google Scholar 

  2. Neubauer S, Krahe T, Schindler R, Hillenbrand H, Entzeroth C, Ertl G, Lackner K and Kochsiek K (1991)Society of Magnetic Resonance Tenth Annual Meeting, San Francisco p. 579.

  3. Gober JR, Norris SL, Henzie GM, Haywood LJ, Halls JM, Boswell WD, Coletti PM and Terk MR (1991)Society of Magnetic Resonance Tenth Annual Meeting, San Francisco p. 576.

  4. Ouwerkerk R, van Echteld CJA, Staal GEJ and Rijksen G (1989)Biochim Biophys Acda 1010: 294.

    Google Scholar 

  5. Gupta RK, Benovic JL and Rose ZB (1978)J Biol Chem 253: 6165.

    Google Scholar 

  6. Gupta RK, Benovic JL and Rose ZB (1978)J Biol Chem 253: 6172.

    Google Scholar 

  7. Bock JL, Wenz B and Gupta RK (1985)Blood 65: 1526.

    Google Scholar 

  8. Brewer GJ (1974) InThe Red Blood Cell, vol 1 (D. MacN Surgenor ed) pp. 479–481, New York: Academic Press.

    Google Scholar 

  9. Bartlett GR (1968)Biochim Biophys Acda 156: 221.

    Google Scholar 

  10. Labotka RJ, Glonek T, Hruby MA and Honig GR (1976)Biochem Med 15: 311.

    Google Scholar 

  11. Palmano KP, Whiting PJ and Hawthorne JN (1977)Biochem J 167: 229.

    Google Scholar 

  12. Whiting PH, Palmano KP and Hawthorne JH (1979)Biochem J 179: 549.

    Google Scholar 

  13. IngwallJS (1992) in press.

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Authors and Affiliations

  1. Departments of Medicine and Physiological Chemistry, University of Wüirzburg, Germany

    Michael Horn, Stefan Neubauer, Michael Bomhard, Marcus Kadgien, Klaus Schnackerz & Georg Ertl

Authors
  1. Michael Horn
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  2. Stefan Neubauer
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  3. Michael Bomhard
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  4. Marcus Kadgien
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  5. Klaus Schnackerz
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  6. Georg Ertl
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Horn, M., Neubauer, S., Bomhard, M. et al. 31P-NMR spectroscopy of human blood and serum: first results from volunteers and patients with congestive heart failure, diabetes mellitus and hyperlipidaemia. MAGMA 1, 55–60 (1993). https://doi.org/10.1007/BF01760400

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  • DOI: https://doi.org/10.1007/BF01760400

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