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1.
BOOK
get availability status
Sustainable innovation and regional development : rethinking innovative milieus (2017)
Cheltenham, UK : Edward Elgar Pub.
Series Statement: [New horizons in regional science]
Note: [Contents: Introduction: Sustainability, Innovative Milieus And Territorial Development ; PART I SUSTAINABLE INNOVATION, GLOBAL ANCHORING OF TERRITORIAL PRODUCTIVE SYSTEMS, AND COMPETITIVENESS 1. The Territories of ‘Sustainable’ Innovation: From Local Milieus to ‘Responsible’ Communication: The Case of Photovoltaics and Sustainable Finance in Western Switzerland ; 2. Innovation in the Sustainable Renovation Sector in Île-De-France ; 3. Border-Crossing Sustainable Innovation Processes – German Knowledge-Intensive Business Services (KIBS) in Green Construction ; 4. Living PlanIT and the Development of the ‘PlanIT Urban Operating System tm’: The Geographies of an Innovation ; 5. The Sustainable Water Campus in Leeuwarden: Towards an Anchoring Milieu or a ‘Hollow Term’? ; PART II SUSTAINABLE INNOVATION TOWARDS AN INTEGRATED TERRITORIAL DEVELOPMENT ; 6. Bairro Alto Revisited: Sustainable Innovations, Reputation Building and Urban Development ; 7. Innovative Rurban Networks in Rome ; 8. Innovation in Sustainable Tourism Projects in Alpine Resorts ; PART III SUSTAINABLE INNOVATION, ECONOMIC RESTRUCTURING AND REGIONAL PRODUCTIVE SYSTEMS ; 9. The Great Basque Transformation Towards Sustainable Innovations ; 10. Atlantic Nautical Network: An Inter-Regional Organizational System to Promote Innovation in Support of Sustainable Development ; 11. From Regional Production System to Regional Innovation System – Evolutional Changes of Suwa Industrial Region in Japan ; Conclusion: Relaunching GREMI: A Scientific Trajectory]
Type of Medium: Monograph available for loan
Pages: xx, 267 Seiten, Illustrationen, Diagramme
ISBN: 9781784712204 (hardback)
Branch Library: PIK Library
2.
Paper (German National Licenses)
Prenatal diagnosis of familial amyloidotic polyneuropathy: evidence for an early expression of the associated transthyretin methionine 30 (1990)
Springer
Human genetics <Berlin> 85 (1990), S. 623-626 
ISSN: 1432-1203
Source: Springer Online Journal Archives 1860-2000
Topics: Biology , Medicine
Notes: Summary Transthyretin methionine 30 (TTR Met 30), which is associated with familial amyloidotic polyneuropathy, originates in a single base substitution (A for G) in the second exon of the TTR gene. This autosomal dominant disease can be diagnosed by RFLP analysis of NsiI-digested DNA. The amplification of DNA by PCR improves the diagnosis method, making it suitable for prenatal diagnosis. Using PCR-amplified DNA, prenatal diagnosis of two at-risk fetuses was performed. Control Met 30 and normal DNA (either genomic or produced by site directed mutagenesis) were processed in parallel. The diagnosis was made by hybridization with allele-specific oligonucleotide probes, and later confirmed by screening of the mutant protein in the amniotic fluid and, when possible, in the sera from the newborns. TTR Met 30 was detected in the amniotic fluid of a positive fetus whose father was the carrier of the mutation. This indicates that the mutant protein is expressed very early in development.
Type of Medium: Electronic Resource
3.
Paper (German National Licenses)
ISSN: 1432-1203
Source: Springer Online Journal Archives 1860-2000
Topics: Biology , Medicine
Notes: Abstract The most frequent transthyretin (TTR) variant associated with hereditary amyloidosis is TTR Met 30, which has its major focus in Portugal, although it also occurs in many other countries. The distribution of the mutation and its occurrence in a CpG dinucleotide lead us to question the origin of the mutation and the possibility of its having originated in Portugal. In order to investigate these questions, we studied the distribution of haplotypes associated with the Met 30 mutation in families from different European countries. All the analysed Portuguese families presented the same haplotype associated with the Met 30 mutation (haplotype I). The same was found for the Swedish and Spanish families studied. However, a distinct haplotype (haplotype III) was found in three families, one Italian, one English and one Turkish. These results suggest that, although the Portuguese Met 30 carriers might have one founder, the mutation probably recurred in populations in Europe in a similar manner to that reported in Japan. In this study, we have also analysed the haplotypes associated with other TTR variants frequent in the Portuguese population.
Type of Medium: Electronic Resource
4.
Paper (German National Licenses)
ISSN: 1432-1203
Source: Springer Online Journal Archives 1860-2000
Topics: Biology , Medicine
Notes: Summary As part of an epidemiological study that aims to characterize chemically the mutation(s) in transthyretin (TTR) related to familial amyloidotic polyneuropathy (FAP) of different ethnic origins, studies were carried out on TTR from two FAP kindreds of Italian origin. Two different criteria were employed in the characterization of TTR from these kindreds: (1) immunoblotting of cyanogen bromide fragments for screening of TTR(Met30) and (2) isoelectric focusing. TTR(Met30) was not detected but other substitutions were demonstrated using isoelectric focusing techniques. One of the variants found is a basic TTR variant. The substitutions occurring in the variant TTRs of these two kindreds are not known and are presently under study.
Type of Medium: Electronic Resource
5.
Paper (German National Licenses)
ISSN: 1432-1203
Source: Springer Online Journal Archives 1860-2000
Topics: Biology , Medicine
Notes: Summary Familial amyloidotic polyneuropathy (FAP) is an autosomal dominant genetic disease characterized by systemic accumulation of amyloid fibrils. A major component of FAP anyloid has been identified as variant transthyretin (TTR, also called prealbumin). In particular, a variant with the substitution 30Val→Met has been commonly found in FAP of various ethnic groups. To understand the origin and spread of the Val→Met mutation, we analyzed DNA polymorphisms associated with the TTR gene in six Japanese FAP families and several Portuguese FAP patients. Three distinct haplotypes associated with the Val→Met mutation were identified in Japanese FAP families, one of which was also found in Portuguese patients. On the other hand, it was found that the Val→Met mutation can be explained by a C-T transition at the CpG dinucleotide sequence of a mutation hot spot. Thus, our findings indicate that the Val→Met mutation has probably recurred in the human population, to generate FAP families of independent origin.
Type of Medium: Electronic Resource
6.
PAPER (OA)
Shaky foundations: Policy lessons from America's historic housing crash (2008)
Levy Economics Institute of Bard College Annandale-on-Hudson, NY
Publication Date: 2015-04-27
Description: A bursting asset bubble inevitably requires central bank action, usually when it is already too late and with adverse spillover effects. In this sense, the Federal Reserve and other central banks already target asset prices; yet, by taking aim at them only on the way down - as in the current housing and credit crisis - the Big Banks create a self-perpetuating cycle of perverse incentives and moral hazard that often gives rise to yet another round of bubbles. The US central bank's current premise is that policymakers cannot and should not target asset bubbles. However, the housing story has rendered untenable the prevailing belief that bubbles are impossible to spot ahead of time. The warning signals were ubiquitous - for example, price charts showing home values rising impossibly into the stratosphere, and Wall Street's increasing reliance on housing-backed bonds for its record-setting profits. It has become abundantly clear that there was plenty the Fed could have done to discourage speculative behavior and put a stop to predatory lending. Recent US experience has bolstered the view that asset prices must come under the central bank's purview in order for the economy to retain some semblance of stability. Former Fed Chairman Paul Volcker recently called for a broader regulatory role for the central bank in light of the housing-centered credit crisis. Indeed, Treasury Secretary Henry Paulson's latest plan for tackling the crisis involves giving the Fed vast new authority to regulate investment banks, not just depository institutions. However, news analyst Pedro Nicolaci da Costa argues that attitude changes among regulators will be even more important than shifts in mandate in ensuring that regulators like the Fed do their jobs properly.
Keywords: ddc:330 ; Wohnungsmarkt ; Finanzmarktkrise ; Subprime-Hypothek ; Börsenkurs ; Bubbles ; Wertpapierspekulation ; USA
Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
Language: eng
Type: doc-type:report
7.
Paper (German National Licenses)
Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP) (1991)
s.l. : American Chemical Society
Biochemistry 30 (1991), S. 2415-2421 
ISSN: 1520-4995
Source: ACS Legacy Archives
Topics: Biology , Chemistry and Pharmacology
Type of Medium: Electronic Resource
8.
Paper (German National Licenses)
Family Studies of the Genetic Abnormality in Transthyretin (Prealbumin) in Portuguese Patients with Familial Amyloidotic Poly neuropathy (1984)
Oxford, UK : Blackwell Publishing Ltd
ISSN: 1749-6632
Source: Blackwell Publishing Journal Backfiles 1879-2005
Topics: Natural Sciences in General
Type of Medium: Electronic Resource
9.
Paper (German National Licenses)
An equivalence factor between CO2 avoidedemissions and sequestration – description andapplications in forestry (2000)
Springer
ISSN: 1573-1596
Keywords carbon accounting ; carbon sequestration ; carbon sinks ; carbon storage ; equivalence time ; equivalence factor ; permanence ; tonne.year
Source: Springer Online Journal Archives 1860-2000
Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
Notes: Abstract Concern about the issue of permanence andreversibility of the effects of carbon sequestrationhas led to the need to devise accounting methods thatquantify the temporal value of storing carbon that hasbeen actively sequestered or removed from theatmosphere, as compared to carbon stored as a resultof activities taken to avoid emissions. This paperdescribes a method for accounting for the atmosphericeffects of sequestration-based land-use projects inrelation to the duration of carbon storage. Firstly,the time period over which sequestered carbon shouldbe stored in order to counteract the radiative forcingeffect of carbon emissions was calculated, based onthe residence time and decay pattern of atmosphericCO2, its Absolute Global Warming Potential. Thistime period was called the equivalence time, andwas calculated to be approximately 55 years. From thisequivalence time, the effect of storage of 1 tCO2 for 1 year was derived, and found to besimilar to preventing the effect of the emission of0.0182 tCO2. Potential applications of thistonne.year figure, here called the equivalencefactor, are then discussed in relation to theestimation of atmospheric benefits over time ofsequestration-based land use projects.
Type of Medium: Electronic Resource
10.
Paper (German National Licenses)
Accounting for time in Mitigating Global Warming through land-use change and forestry (2000)
Springer
ISSN: 1573-1596
Keywords carbon dioxide ; deforestation ; discount rate ; global warming ; greenhouse effect ; land-use change ; mitigation ; time preference
Source: Springer Online Journal Archives 1860-2000
Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
Notes: Abstract Many proposed activities formitigating global warming in the land-use change and forestry(LUCF) sector differ from measures to avoid fossilfuel emissions because carbon (C) may be held out ofthe atmosphere only temporarily. In addition, thetiming of the effects is usually different. Many LUCFactivities alter C fluxes to and from the atmosphereseveral decades into the future, whereas fossil fuelemissions avoidance has immediate effects. Non-CO2 greenhouse gases (GHGs), which are animportant part of emissions from deforestation inlow-latitude regions, also pose complications forcomparisons between fossil fuel and LUCF, since themechanism generally used to compare these gases(global warming potentials) assumes simultaneousemissions. A common numeraire is needed to expressglobal warming mitigation benefits of different kindsof projects, such as fossil fuel emissions reduction,C sequestration in forest plantations, avoideddeforestation by creating protected areas and throughpolicy changes to slow rates of land-use changes suchas clearing. Megagram (Mg)-year (also known as`ton-year') accounting provides a mechanism forexpressing the benefits of activities such as these ona consistent basis. One can calculate the atmosphericload of each GHG that will be present in each year,expressed as C in the form of CO2 and itsinstantaneous impact equivalent contributed by othergases. The atmospheric load of CO2-equivalent Cpresent over a time horizon is a possible indicator ofthe climatic impact of the emission that placed thisload in the atmosphere. Conversely, this index alsoprovides a measure of the benefit of notproducing the emission. One accounting methodcompares sequestered CO2 in trees with theCO2 that would be in the atmosphere had thesequestration project not been undertaken, whileanother method (used in this paper) compares theatmospheric load of C (or equivalent in non-CO2GHGs) in both project and no-project scenarios.Time preference, expressed by means of a discount rateon C, can be applied to Mg-year equivalencecalculations to allow societal decisions regarding thevalue of time to be integrated into the system forcalculating global warming impacts and benefits. Giving a high value to time, either by raising thediscount rate or by shortening the time horizon,increases the value attributed to temporarysequestration (such as many forest plantationprojects). A high value for time also favorsmitigation measures that have rapid effects (such asslowing deforestation rates) as compared to measuresthat only affect emissions years in the future (suchas creating protected areas in countries with largeareas of remaining forest). Decisions on temporalissues will guide mitigation efforts towards optionsthat may or may not be desirable on the basis ofsocial and environmental effects in spheres other thanglobal warming. How sustainable development criteriaare incorporated into the approval and creditingsystems for activities under the Kyoto Protocol willdetermine the overall environmental and social impactsof pending decisions on temporal issues.
Type of Medium: Electronic Resource