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  • 11
    Electronic Resource
    Electronic Resource
    Study on Reliability Analysis of Tailings Dam Stability (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 2619-2622 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Since the construction method of tailings dams determines the uneven distribution oftailings, a reliability theory is introduced to analyze the stability of tailings dams. Based on the limitequilibrium method and reliability theory, the sensitivity and reliability of a typical tailings dam areanalyzed. Reliability analyses with different types of the variable probability distribution typesshow that the effect of the probability distribution type on reliability analysis can almost be ignored.Besides, the sensitivity analyses of different variables show that the strength indexes and density oftailings will affect the analysis results of stability reliability. Therefore the strength indexes c, φand density ρ must be considered as basic variables to analyze the stability reliability of tailingsdams
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.2619.pdf
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  • 12
    Electronic Resource
    Electronic Resource
    Tissue Engineering Scaffolds of Bioceramics and New Bone Growth (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 368-372 (Feb. 2008), p. 1161-1165 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The paper describes β-TCP/DCHA and mineral phase structural bioceramics(CHA) as well astheir 3-D structures, bioactivity, degradability and introducing new bone growth. FT-IR, XRD, SEM andMicro-CT were used to evaluate β-TCP/DCHA and mineral phase structural ceramics before and afterimplantation. Osteoblasts were immersed in the bioceramics and implanted in the rabbit femora. Theexperimental results showed that new bone grown in β-TCP/DCHA, and scaffolds were degraded withnew bone formation and growth. The results indicated that β-TCP/DCHA was a better tissue engineeringmaterial. A kind of biomaterial (β-TCP/CHA) can be used for in situ formation or in vitro individuationformation. The experimental results indicated that β-TCP/CHA possessed better osteoblast affinity.Osteoblasts can adhere, proliferate and grow better on the material. The experiments in vivo showed thematerials bonded with osseous tissue. The implants were degraded obviously after 6 months, and newbone replaced degradation materials
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.368-372.1161.pdf
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  • 13
    Electronic Resource
    Electronic Resource
    A Preliminary Model Accounting for the Suction Pressure in CMP Process (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 737-741 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Chemical mechanical polishing (CMP) is a widely used technique to achieve high level ofglobal and local planarity required in modern integrate circuit (IC) industries and hard diskmanufacturing process, etc., which pleas for concentrate researches. The main purpose of the presentresearch is in an attempt to express the counterintuitive experimental aftermath: the ‘negative’pressure, i.e., a suction force occurred in conventional commercial CMP process. A preliminary twotiers wafer-scale flow model for CMP is presented considering the roughness as well as the elasticityof the bulk pad substrate. Numerical simulations were conducted to elucidate the contact pressure andflow pressure distributions. The results show that a divergence region appears near the leading edge,which contributes to the suction pressure. A stress-richened area near the edges will give rise to overpolishing. The research aftermaths agree well with the experiments, that validate the proposedanalysis to some extend. This will shed lights on the mechanism of CMP process, which for a longtime is considered as a black art where empirical or semi-empirical data are dependent upon tooptimize the CMP parameters
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.737.pdf
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  • 14
    Electronic Resource
    Electronic Resource
    A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 201-207 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cyclic nucleotide phosphodiesterases (PDEs) comprise a large family of enzymes that regulate a variety of cellular processes. We describe a family of potent PDE4 inhibitors discovered using an efficient method for scaffold-based drug design. This method involves an iterative approach starting with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1059
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  • 15
    Electronic Resource
    Electronic Resource
    Calculation on Temperature Rise of CMP Process: Roughness Effects Considered (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 575-578 (Apr. 2008), p. 1348-1353 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Chemical mechanical polishing (CMP) has been widely accepted in modern integratedcircuit (IC) industries and hard disk manufacturing processes, to insure wafer surface with high levelof global and local planarity required. In CMP process, temperature rise has two-edged influences:temperature-rise accelerates the chemical activity and the motion of nano-particles contained in theslurry through which material removal ratio (MRR) is enhanced; the other side of the same coin is,however, that it will soften the pad surface and subsequently reduce the MRR. Furthermore, it isfound that temperature-rise would cause agglomeration of nano-particles, which would cause thewafer surface defect. The net effects of temperature thus should be under investigation with scrutiny.In an attempt to study the temperature variation and influencing rule, in this paper we firstly establishthe flow equation considering pad roughness, coupling the energy equation on the basis ofthermodynamics. Then, by taking numerical simulation which is carried out to give out thetemperature distribution of conventional CMP process. The results show that temperature-rise in theCMP process is very minor. The research will surely shed some lights on the mechanism of CMP andlay a feasible foundation for possible future utilization
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.575-578.1348.pdf
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  • 16
    Electronic Resource
    Electronic Resource
    Numerical Simulation of Hydrostatic Extruding Cu/Al Bimetal Clad through Equal-Strain Contour Concave Die (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 575-578 (Apr. 2008), p. 792-798 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A bimetal composite material is a variant of the typical composite that is composed oftwo materials joined at their interface surface. The advantage of clad material is that thecombination of different properties of materials can satisfy both the need of good mechanicalproperties and the demand of user such as electrical properties simultaneously. This paper isconcerned with the hydrostatic extrusion process of copper-clad aluminum rod. The commerciallyavailable finite element program ANSYS was used to simulate the process of hydrostatic extrusionfor Cu/Al bimetal composite through the equal-strain contour concave dies. The relative slippagebetween the inner and outer metals under the condition of different friction factors is studied, andthe stress-strain distribution in the billet was analyzed. Experiment test was carried out; it wasfound that the experimental result has good agreement with relative slippage from the finite elementanalysis
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.575-578.792.pdf
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  • 17
    Electronic Resource
    Electronic Resource
    Pad Effects on Slurry Flows in CMP System (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 575-578 (Apr. 2008), p. 1222-1227 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Chemical mechanical polishing (CMP) is a widely adopted technique to achieve high levelof global and local planarity required in modern integrate circuit (IC) industries, wherein the padproperties weigh heavily on the final performance. A preliminary two-dimensional wafer-scale flowmodel for CMP is presented considering the roughness, the elasticity, as well as the porosity of thepad. Numerical simulations were conducted to show the slurry flow features’ variations due to padparameters change. The results show that the porosity of the pad is conducive to slurry delivering, andsmall porous parameter will lead to prominent increase of load capability, accounting for largermaterial removal rate (MRR) whilst the elasticity of the pad has a more complex influence. The roughsurface carries additional fluid in the valleys of the polishing pad thereby provide some chemicalreactions. The model will shed lights on the mechanism of CMP process, which is for a long timeconsidered as a difficult circle to square
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.575-578.1222.pdf
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  • 18
    Electronic Resource
    Electronic Resource
    Investigation on Creep Damage of Natural Gas Storage in Salt Rock Layer (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 324-325 (Nov. 2006), p. 451-454 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To research the creep behavior of salt rock, the uniaxial and triaxial creep experimentswere carried out under different deviatoric stresses and same confining pressure or different confiningpressures and same deviatoric stress. The experiment results showed that the analysis on the creepdamage of salt rock should consider the influence of confining pressure and deviatoric stress. Byintroducing the damage variable to the Norton Power law of salt rock, a new constitutive law of saltrock was presented. The damage equivalent stress was the function of the confining pressure and thedeviatoric stress in the new constitutive law. The constitutive law can embody the steady creep andaccelerative creep of salt rock, in which the parameters are obtained by simulating the experimentaldata of salt rock in some salt mine. The theoretic results are in good agreement with the experimentalresults.The new constitutive law was embedded in the three dimension numerical codes. The natural gasstorage in the salt mine was analyzed by the new constitutive law. The evolvement law of damagebound and the displacement law around the natural gas storage were studied under the minimalnatural gas storage pressure. The continuous operating time of the natural gas storage was alsoanalyzed under the pressure. The research conclusions are expected to be applied in the natural gasstorage projects in salt rock layer
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.324-325.451.pdf
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  • 19
    Electronic Resource
    Electronic Resource
    MicroCT Aided Scaffold Design and Preparation (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1584-1586 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Bone repair method has run to a new stage of bone tissue engineering. Doctors use bonescaffold to fill bone trauma and expect human regeneration ability to reconstruct bone trauma while boneis degrading. Scaffold is essential to bone tissue engineering. Scaffold should introduce new bone withscaffold’s conduction channel. But it’s still very difficult for scaffold to mimic fine structure of bone.Ideal scaffold should have similar component and microstructure to natural bone, which makes it morebiocompatible and better to reconstructed bone. So we forward microCT aided design and preparation tosolve this problem. MicroCT outputs both shape and three-dimensional internal density information.Then, we build computer model of scaffold with acquired microstructure. We fabricate scaffold thatmimics natural bone by 3D rapid prototype machine
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1584.pdf
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  • 20
    Electronic Resource
    Electronic Resource
    A novel chemiluminescence flow-through sensor for the determination of analgin (1999)
    Springer
    Fresenius' journal of analytical chemistry 365 (1999), S. 381-383 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A novel chemiluminescence (CL) flow-through sensor for the determination of analgin with flow-injection analysis (FIA) based on the auto-oxidation of analgin in the presence of Tween 80 sensitized by Rhodamine 6G immobilized on a cation-exchange column is described. This sensor responds linearly to the analgin concentration in the range of 0.4 ∼ 10 mg/L, with a detection limit (3σ) of 0.15 mg/L. A complete analysis, including sampling and washing, takes 1 min with a relative standard deviation of 〈 5%. The sensor is stable for over 200 determinations and has successfully been applied to the determination of analgin in pharmaceutical preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051506
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