ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    facet.materialart.
    Unbekannt
    A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2005-01-08
    Beschreibung: Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pressures. Four strategies for gene expression are apparent during the parasites' life cycle: (i) housekeeping; (ii) host-related; (iii) strategy-specific related to invasion, asexual replication, and sexual development; and (iv) stage-specific. We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3' untranslated region motif is implicated in this process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, Neil -- Karras, Marianna -- Raine, J Dale -- Carlton, Jane M -- Kooij, Taco W A -- Berriman, Matthew -- Florens, Laurence -- Janssen, Christoph S -- Pain, Arnab -- Christophides, Georges K -- James, Keith -- Rutherford, Kim -- Harris, Barbara -- Harris, David -- Churcher, Carol -- Quail, Michael A -- Ormond, Doug -- Doggett, Jon -- Trueman, Holly E -- Mendoza, Jacqui -- Bidwell, Shelby L -- Rajandream, Marie-Adele -- Carucci, Daniel J -- Yates, John R 3rd -- Kafatos, Fotis C -- Janse, Chris J -- Barrell, Bart -- Turner, C Michael R -- Waters, Andrew P -- Sinden, Robert E -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):82-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK. nhall@tigr.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637271" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3' Untranslated Regions ; Animals ; Anopheles/parasitology ; Computational Biology ; Evolution, Molecular ; Gene Expression Profiling ; Gene Silencing ; Genes, Protozoan ; *Genome, Protozoan ; *Life Cycle Stages ; Malaria/parasitology ; Oligonucleotide Array Sequence Analysis ; Plasmodium/*genetics/*growth & development/metabolism ; Plasmodium berghei/genetics/growth & development/metabolism ; Plasmodium chabaudi/genetics/growth & development/metabolism ; Plasmodium falciparum/genetics/growth & development/metabolism ; Plasmodium yoelii/genetics/growth & development/metabolism ; Proteome/*analysis ; Proteomics ; Protozoan Proteins/analysis ; RNA, Messenger/genetics/metabolism ; RNA, Protozoan/genetics/metabolism ; Selection, Genetic ; Transcription, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 2
    facet.materialart.
    Unbekannt
    Discovery of gene function by expression profiling of the malaria parasite life cycle (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-08-02
    Beschreibung: The completion of the genome sequence for Plasmodium falciparum, the species responsible for most malaria human deaths, has the potential to reveal hundreds of new drug targets and proteins involved in pathogenesis. However, only approximately 35% of the genes code for proteins with an identifiable function. The absence of routine genetic tools for studying Plasmodium parasites suggests that this number is unlikely to change quickly if conventional serial methods are used to characterize encoded proteins. Here, we use a high-density oligonucleotide array to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle. Genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Le Roch, Karine G -- Zhou, Yingyao -- Blair, Peter L -- Grainger, Muni -- Moch, J Kathleen -- Haynes, J David -- De La Vega, Patricia -- Holder, Anthony A -- Batalov, Serge -- Carucci, Daniel J -- Winzeler, Elizabeth A -- MC_U117532067/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2003 Sep 12;301(5639):1503-8. Epub 2003 Jul 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. leroch@scripps.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12893887" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anopheles/parasitology ; Cell Cycle ; Chromosomes/genetics ; Cluster Analysis ; Erythrocytes/parasitology ; *Gene Expression ; *Gene Expression Profiling ; Gene Expression Regulation, Developmental ; *Genes, Protozoan ; Humans ; Life Cycle Stages ; Liver/parasitology ; Malaria, Falciparum/parasitology ; Oligonucleotide Array Sequence Analysis ; Plasmodium falciparum/*genetics/*growth & development/metabolism ; Proteome ; Protozoan Proteins/genetics/metabolism/physiology ; RNA, Messenger/genetics/metabolism ; RNA, Protozoan/genetics/metabolism ; Salivary Glands/parasitology ; Sporozoites/genetics/growth & development ; Transcription, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...