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  • Soil transfer  (2)
  • Cell Biology, Medicine, Diseases  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Mycorrhiza 3 (1993), S. 97-106 
    ISSN: 1432-1890
    Schlagwort(e): Soil transfer ; Reforestation ; Populus ; Phosphorus ; Boreal forest
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Soil transfers, presumed to contain mycorrhizal fungal inoculum from a native plant community, were applied to rooted cuttings and volunteer plants of Populus balsamifera L. to improve their growth on an abandoned mined site in south central Alaska. The objectives of the study were to determine (1) if these soil transfers could be substituted for additional P fertilizer when applied with a base level of NP fertilizer to improve growth, and (2) if P added to treatments receiving a base level of NP fertilizer and soil transfer would suppress mycorrhizal formation. Physical dimensions of plants were measured near the beginning and end of each of two growing seasons. Several plants per plot were harvested at the end of year 2 to determine mycorrhizal formation, current growth, and leaf nutrient concentrations. Plant height was significantly increased only when soil transfer and additional P treatments were combined. Response to additions of P fertilization alone or soil transfer alone were not significantly different from each other. Current twig growth increased with either treatment alone or both combined. Soil transfer on cuttings resulted in more ectomycorrhizal formation than either the control or additional P. Leaf N concentrations on cuttings and volunteers increased when plants were treated with soil transfer. Similar growth responses were achieved by soil transfers or additional P, but mycorrhizal formation was improved with the soil transfer treatments. P added to the base level plus soil transfer did not suppress or improve mycorrhizal formation compared to that with soil transfer alone.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Mycorrhiza 3 (1993), S. 107-114 
    ISSN: 1432-1890
    Schlagwort(e): Soil transfer ; Reforestation ; Populus ; Alnus ; Boreal forest
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Soil transfers from an intermediate successional site and a mature forest site were applied to Populus balsamifera L. cuttings and Alnus crispa (Ait.) Pursh seedlings placed on an abandoned mined site in south central Alaska to improve plant establishment. Mycorrhizal fungi in the soil transfers from the two successional stages were hypothesized to have different effects on plant species that colonize disturbed sites at different times or on different substrates. The site consisted of coarse, dry, low-nutrient spoils and was naturally colonized by scattered P. balsamifera but not A. crispa, although seed sources for both were adjacent to the site. Physical dimensions of the transplanted seedlings and cuttings were measured at the beginning and end of each growing season. Selected plants were harvested at the end of the 2-year study and examined for mycorrhizal formation, current growth, and leaf tissue nutrient concentrations. Both plant species were taller when treated with the soil transfers from the mature forest than with soils from the intermediate site although the increase for A. crispa was greater. Physical dimensions, current growth, and nutrient concentrations were greater when A. crispa was treated with the mature soil transfer compared with the intermediate soil transfer. Mycorrhizae which infected Alnus were predominantly a brown woody type, while other types accounted for greater relative mycorrhizal infection percentage on Populus. Insufficient quantities of mycorrhizal inoculum of suitable species, as well as low moisture and low nutrient conditions, may be factors limiting A. crispa colonization on primary disturbed sites in south central Alaska.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2017-12-01
    Beschreibung: Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug mechanism of action. Using chemical proteomics, we analyzed the target spectrum of 243 clinically evaluated kinase drugs. The data revealed previously unknown targets for established drugs, offered a perspective on the "druggable" kinome, highlighted (non)kinase off-targets, and suggested potential therapeutic applications. Integration of phosphoproteomic data refined drug-affected pathways, identified response markers, and strengthened rationale for combination treatments. We exemplify translational value by discovering SIK2 (salt-inducible kinase 2) inhibitors that modulate cytokine production in primary cells, by identifying drugs against the lung cancer survival marker MELK (maternal embryonic leucine zipper kinase), and by repurposing cabozantinib to treat FLT3-ITD–positive acute myeloid leukemia. This resource, available via the ProteomicsDB database, should facilitate basic, clinical, and drug discovery research and aid clinical decision-making.
    Schlagwort(e): Cell Biology, Medicine, Diseases
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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