ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
O-alkyl, O-(1-methylthioethylideneamino) phosphoramidates
;
Quantitative structure-retention relationship (QSRR)
;
Reversed-phase LC
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary By using factor analysis, cluster analysis and multiple linear regression methods, two parameters, FHF and ECCR, were selected from eight solute-related structure parameters as showing the best correlation with retention data. The relationship between the retention data (k) and these two structure parameters were established for ten O-alkyl, O-(1-methylthioethylideneamino) phosphoramidate compounds under the experimental conditions studied. Retention data (k) for six other compounds that have a high correlation with structure parameters were predicted using these QSRR equations. The system was evaluated by comparing the experimentalk values with the predicted ones. Good agreement was obtained between the experimental and predictedk values.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02467621
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