ALBERT

Description: In this June 29, 1986 case study, a radiative transfer model is used to simulate the aircraft multichannel microwave brightness temperatures presented in the Adler et al. (1990) paper and to study the convective storm structure. Ground-based radar data are used to derive hydrometeor profiles of the storm, based on which the microwave upwelling brightness temperatures are calculated. Various vertical hydrometeor phase profiles and the Marshall and Palmer (M-P, 1948) and Sekhon and Srivastava (S-S, 1970) ice particle size distributions are experimented in the model. The results are compared with the aircraft radiometric data. The comparison reveals that the M-P distribution well represents the ice particle size distribution, especially in the upper tropospheric portion of the cloud; the S-S distribution appears to better simulate the ice particle size at the lower portion of the cloud, which has a greater effect on the low-frequency microwave upwelling brightness temperatures; and that, in deep convective regions, significant supercooled liquid water (about 0.5 g/cu m) may be present up to the -30 C layer, while in less convective areas, frozen hydrometeors are predominant above -10 C level.

Description: A three-dinensional cloud model-microwave radiative transfer model combination is used to study the relations among the precipitation and other microphysical characteristics of a tropical oceanic squall line and the upwelling radiance at pertinent microwave frequencies. Complex brightness temperature-rain rate relations are evident at the full horizontal resolution (1.5 km) of the models, with spatial averaging producing smoother, shifter relations in most cases. Nonprecipitating cloud water is shown to be important in understanding the resulting distribution of brightness temperature. At the mature stage, convective portions of the cloud system are shown to produce different brightness temperature relations than the stratiform portion, primarily related to the distribution of cloud water. The evolution of the convective system from a small convective complex through its mature stage and the beginning of its dissipation also is shown to result in a variation of brightness temperature-rain relations, related to the distribution of cloud water and the evolution of ice in the precipitating system. The results of the study point to the need to take into account the evolution of nonprecipitating cloud water and precipitation-sized ice in the retrieval of rain from passive microwave space observations. This effect is evident for both the life cycle of individual convective elements and the life cycle of the convective system as a whole.

Description: In microwave radiative transfer model simulations, the Mie calculations usually consume the majority of the computer time necessary for the calculations (70 to 86 percent for frequencies ranging from 6.6 to 183 GHz). For a large array of atmospheric profiles, the repeated calculations of the Mie codes make the radiative transfer computations not only expensive, but sometimes impossible. It is desirable, therefore, to develop a set of Mie tables to replace the Mie codes for the designated ranges of temperature and frequency in the microwave radiative transfer calculation. Results of using the Mie tables in the transfer calculations show that the total CPU time (IBM 3081) used for the modeling simulation is reduced by a factor of 7 to 16, depending on the frequency. The tables are tested by computing the upwelling radiance of 144 atmospheric profiles generated by a 3-D cloud model (Tao, 1986). Results are compared with those using Mie quantities computed from the Mie codes. The bias and root-mean-square deviation (RMSD) of the model results using the Mie tables, in general, are less than 1 K except for 37 and 90 GHz. Overall, neither the bias nor RMSD is worse than 1.7 K for any frequency and any viewing angle.

Description: Enhanced screening for the Visual Impairment/Intracranial Pressure (VIIP) syndrome has been implemented to better characterize the ocular and vision changes observed in some long-duration crewmembers. This includes implementation of in-flight ultrasound in 2010 and optical coherence tomography (OCT) in 2013. Potential risk factors for VIIP include cardiovascular health, diet, anatomical and genetic factors, and environmental conditions. Carbon dioxide (CO2), a potent vasodilator, is chronically elevated on the International Space Station (ISS) relative to ambient levels on Earth, and is a plausible risk factor for VIIP. In an effort to understand the possible associations between CO2 and VIIP, this study explores the relationship of ambient CO2 levels on ISS compared to inflight ultrasound and OCT measures of the eye obtained from ISS crewmembers. CO2 measurements were aggregated from Operational Data Reduction Complex and Node 3 major constituent analyzers (MCAs) on ISS or from sensors located in the European Columbus module, as available. CO2 levels in the periods between each ultrasound and OCT session are summarized using timeseries metrics, including time-weighted means and variances. Partial least squares regression analyses are used to quantify the complex relationship between specific ultrasound and OCT measures and the CO2 metrics simulataneously. These analyses will enhance our understanding of the possible associations between CO2 levels and structural changes to the eye which will in turn inform future analysis of inflight VIIP data.

Description: Research by NASA [1] established that significant risks for visual and ocular impairments associated with increased intracranial pressure (VIIP) are incurred by microgravity spaceflight, especially long-duration missions. It is well established in physiology and pathology that a fundamental role of the microvasculature is to mediate fluid transfers and remodel actively in response to environmental, immune and other stresses. We therefore hypothesize that remodeling of retinal blood vessels necessarily occurs during accommodation of microgravity-induced fluid shifts prior to subsequent development of visual and ocular impairments. Potential contributions of retinal vascular remodeling to VIIP etiology are therefore being investigated by NASA's innovative VESsel GENeration Analysis (VESGEN) software for two studies: (1) U.S. crew members before and after ISS missions, and (2) head-down tilt in human subjects before and after 70 days of bed rest. We anticipate that results of the two studies will be complete by the Investigators Workshop (January 22, 2017). METHODS: For the 2013 NASA NRA award, we are concluding the analysis of 30 degree infrared (IR) Heidelberg Spectralis images of retinal blood vessels by VESGEN (patents pending), a mature, automated software developed as a translational and basic vascular research discovery tool, particularly for retinal vascular disease. Subjects of our retrospective study include eight ISS crew members monitored for routine occupational surveillance pre- and post-flight, who provided their study consents to NASAs Lifetime Surveillance of Astronaut Health (LSAH) in coordination with approval of the VESGEN retrospective study protocol by NASAs Institutional Review Board (IRB). The ophthalmic retinal images (average image resolution, approximately 5.6 microns per pixel) are blinded as to pre and post ISS status until the second portion of our study, when VESGEN results will be correlated with other ophthalmic and medical findings for the crew members. Due to image resolution challenges, a novel Matlab tool was developed for aligning pre and post images, and comparing (querying) the two images for differences in the morphology of small vessels. RESULTS: During the past year, LSAH approved the release of all astronaut retinal images to our study for VESGEN analysis. Substantial progress on the initial blinded portion of the study is in place. We anticipate that VESGEN analysis of the 32 Spectralis IR retinal images will be complete for presentation at the 2017 IWS meeting. CONCLUSIONS: Modified retinal vascular patterning may offer early-stage predictions of ocular changes resulting in decreased visual acuity for the VIIP syndrome. Novel insights provided by VESGEN into progressively pathological and blinding vascular remodeling in the human retina currently help to guide other NIH- and NASA-supported therapeutic studies of retinal disease and modeling of the VIIP risk. Results of our vascular investigation of the retinas of astronauts pre- and post-flight may help advance the understanding of both healthy and pathological adaptations to fluid shifts in microgravity associated with the VIIP syndrome. Preliminary results indicate that imaging of higher resolution, such as the new OCT angiography (OCT-A) technology, will be required to determine conclusively the role of the smaller retinal and choroidal vessels in VIIP etiology.

Description: Carbon dioxide (CO2) levels on ISS have typically averaged 2.3 to 5.3mm Hg, with large fluctuations occurring over periods of hours and days. CO2 has effects on cerebral vascular tone, resulting in vasodilation and alteration of cerebral blood flow(CBF). Increased CBF leads to elevated intracranial pressure(ICP), which is a factor leading to visual disturbance, headaches, and other central nervous system symptoms. Ultrasound of the optic nerve provides a surrogate measurement of ICP. Inflight ultrasounds were implemented as an enhanced screening tool for the Visual Impairment/Intracranial Pressure (VIIP) Syndrome. This analysis examines the relationships between ambient CO2 levels on ISS and ultrasound measures of the eye in an effort to understand how CO2 may be associated with VIIP and to inform future analysis of inflight VIIP data. Results as shown in Figure2, there was a large timeframe where CO2 readings were removed due to sensor fault errors(see Limitations), from June 2011 to January 2012. After extensive cleaning of the CO2 data, metrics for all of the data were calculated (Table2). Preliminary analyses showed possible associations between variability measures of CO2 and AP diameter (Figure3),and average CO2 exposure and ONSD(Figure4). Adjustments for multiple comparisons were not made due to the exploratory nature of the analysis.

Description: A three-dimensional cloud model, radiative transfer model-based simulation system is tested and validated against the aircraft-based radiance observations of an intense convective system in southeastern Virginia on 29 June 1986 during the Cooperative Huntsville Meteorological Experiment. NASA's ER-2, a high-altitude research aircraft with a complement of radiometers operating at 11-micrometer infrared channel and 18-, 37-, 92-, and 183-GHz microwave channels provided data for this study. The cloud model successfully simulated the cloud system with regard to aircraft- and radar-observed cloud-top heights and diameters and with regard to radar-observed reflectivity structure. For the simulation time found to correspond best with the aircraft- and radar-observed structure, brightness temperatures T(sub b) are simulated and compared with observations for all the microwave frequencies along with the 11-micrometer infrared channel. Radiance calculations at the various frequencies correspond well with the aircraft observations in the areas of deep convection. The clustering of 37-147-GHz T(sub b) observations and the isolation of the 18-GHz values over the convective cores are well simulated by the model. The radiative transfer model, in general, is able to simulate the observations reasonably well from 18 GHz through 174 GHz within all convective areas of the cloud system. When the aircraft-observed 18- and 37-GHz, and 90- and 174-GHz T(sub b) are plotted against each other, the relationships have a gradual difference in the slope due to the differences in the ice particle size in the convective and more stratiform areas of the cloud. The model is able to capture these differences observed by the aircraft. Brightness temperature-rain rate relationships compare reasonably well with the aircraft observations in terms of the slope of the relationship. The model calculations are also extended to select high-frequency channels at 220, 340, and 400 GHz to simulate the Millimeter-wave Imaging Radiometer aircraft instrument to be flown in the near future. All three of these frequencies are able to discriminate the convective and anvil portions of the system, providing useful information similar to that from the frequencies below 183 GHz but with potentially enhanced spatial resolution from a satellite platform. In thin clouds, the dominant effect of water vapor is seen at 174, 340, and 400 GHz. In thick cloudy areas, the scattering effect is dominant at 90 and 220 GHz, while the overlaying water vapor can attenuate at 174, 340, and 400 GHz. All frequencies (90-400 GHz) show strong signatures in the core.