Publication Date:
1999-01-08
Description:
Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4(+) helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)- anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4(+), natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schofield, L -- McConville, M J -- Hansen, D -- Campbell, A S -- Fraser-Reid, B -- Grusby, M J -- Tachado, S D -- AI-40171/AI/NIAID NIH HHS/ -- GM 41071/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 8;283(5399):225-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia. schofield@wehi.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9880256" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen Presentation
;
Antigen-Presenting Cells/immunology
;
Antigens/analysis
;
Antigens, CD1/*immunology
;
Antigens, Ly
;
Antigens, Protozoan/*immunology
;
Antigens, Surface
;
Cells, Cultured
;
Glycosylphosphatidylinositols/*immunology
;
Immunoglobulin G/*biosynthesis
;
Interleukin-4/biosynthesis
;
Lectins, C-Type
;
Leishmania mexicana/immunology
;
Major Histocompatibility Complex
;
Mice
;
Mice, Inbred Strains
;
NK Cell Lectin-Like Receptor Subfamily B
;
Plasmodium/immunology
;
Proteins/analysis
;
Protozoan Proteins/immunology
;
T-Lymphocyte Subsets/*immunology
;
T-Lymphocytes, Helper-Inducer/*immunology
;
Trypanosoma brucei brucei/immunology
;
Variant Surface Glycoproteins, Trypanosoma/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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