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Mimosine induces apoptosis in the HL60 human tumor cell line (1999)

Renò, F. ; Tontini, A. ; Burattini, S. ; [et al.]

Springer

Apoptosis 4 (1999), S. 469-477

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ISSN: 1573-675X

Keywords: Apoptosis ; cell cycle synchronization ; HL60 ; hypusine ; K562 ; mimosine.

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Mimosine, a plant amino acid not found in proteins, has been widely used as a synchronizing agent, blocking the progression of cell cycle on the G1/S phase border. The mechanism by which this block is achieved is still unclear. We report that in HL60 cells the synchronization is related to an increase in apoptosis. Another human tumor cell line, K562, is insensitive to both phenomena thereby demonstrating that apoptosis observed in HL60 is line-specific. We hypothesize that the mimosine-induced apoptosis and alteration of the cell cycle is due to the inhibition of hypusine generation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1009608628076

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