Publication Date:
2016-04-29
Description:
Despite decades of study, there are still many unanswered questions about metastasis, the process by which a localized cancer becomes a systemic disease. One of these questions is the nature of the tumor cells that give rise to metastases. Although conventional models suggest that metastases are seeded by single cells from the primary tumor, there is growing evidence that seeding requires the collective action of tumor cells traveling together in clusters. Here, we review this evidence, which comes from analysis of both experimental models and patient samples. We present a model of metastatic dissemination that highlights the activities of clusters of tumor cells that retain and require their epithelial properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheung, Kevin J -- Ewald, Andrew J -- P30 CA006973/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2016 Apr 8;352(6282):167-9. doi: 10.1126/science.aaf6546.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. ; Departments of Cell Biology, Oncology, and Biomedical Engineering, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, MD 21205, USA. andrew.ewald@jhmi.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27124449" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Epithelial Cells/pathology
;
Humans
;
Mice
;
*Models, Biological
;
Neoplasm Metastasis/*pathology
;
Neoplasm Seeding
;
Neoplasms, Experimental/pathology
;
Neoplastic Cells, Circulating/*pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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