ISSN:
0749-1581
Keywords:
Dipyridyl ketones
;
Dipyridylmethanones
;
1H NMR
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Four new dimethylaminated pyridoylpyridine intermediates, bis(3-dimethylamino-2-pyridyl) ketone (1), 6-dimethylamino-3-pyridyl 4-pyridyl ketone (2), 6-dimethylamino-3-pyridyl 3-pyridyl ketone (3) and 6-dimethylamino-3-pyridyl 2-pyridyl ketone (4), have been synthesized and their 100 MHz 1H NMR spectra analysed iteratively as ABC, ABCX and ABXY spin systems. In 2-4 the H-5 shift ortho to the dimethylamino substituent is unaffected by the orientation of the pyridyl substituent, but H-4 and H-2 are increasingly deshielded in the sequence 2-4. In 3, when benzene-d6 replaces chloroform-d1 as solvent, H-5′ and H-4′ in the unsubstituted pyridyl ring suffer appreciable upfield shifts.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260241010
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