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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 40 (1991), S. 261-265 
    ISSN: 1432-1041
    Keywords: Cadralazine ; CGP 22639 ; hydralazine ; systemic lupus ; erythematosus ; complement component C4 ; C3 ; drug-induced autoimmunity ; hydroxylamine ; procainamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of cadralazine and its active metabolite CGP 22639 on the covalent binding reaction of C4 and C3 has been studied. Trypsin-Sepharose was used to activate radio-labelled C3 and C4 and binding of the radio-labelled protein to the trypsin-Sepharose was measured. Cadralazine inhibited 50% of the binding of C3 and C4 at concentrations of 19 mmol/l and 15 mmol/l, respectively. Its active metabolite was more potent and inhibited 50% of the C3 and C4 binding at concentrations of 8 and 3.5 mmol/l, respectively. These concentrations are much higher than those found in plasma during therapy. This is consistent with the clinical observation that in patients with normal kidney function cadralazine is not an inducer of SLE.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2019-08-13
    Description: During 16 years in low-Earth orbit, the suite of exercise hardware aboard the International Space Station (ISS) has matured significantly. Today, the countermeasure system supports an array of physical-training protocols and serves as an extensive research platform. Future hardware designs are required to have smaller operational envelopes and must also mitigate known physiologic issues observed in long-duration spaceflight. Taking lessons learned from the long history of space exercise will be important to successful development and implementation of future, compact exercise hardware. The evolution of exercise hardware as deployed on the ISS has implications for future exercise hardware and operations. Key lessons learned from the early days of ISS have helped to: 1. Enhance hardware performance (increased speed and loads). 2. Mature software interfaces. 3. Compare inflight exercise workloads to pre-, in-, and post-flight musculoskeletal and aerobic conditions. 4. Improve exercise comfort. 5. Develop complimentary hardware for research and operations. Current ISS exercise hardware includes both custom and commercial-off-the-shelf (COTS) hardware. Benefits and challenges to this approach have prepared engineering teams to take a hybrid approach when designing and implementing future exercise hardware. Significant effort has gone into consideration of hardware instrumentation and wearable devices that provide important data to monitor crew health and performance.
    Keywords: Computer Programming and Software; Aerospace Medicine
    Type: JSC-CN-38556 , Annual NASA Human Research Program Investigator''s Workshop (HRP IWS) 2017; Jan 23, 2017 - Jan 26, 2017; Galveston, TX; United States
    Format: application/pdf
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