Publication Date:
2003-02-22
Description:
DNA has a structural basis to array functionalized building blocks. Here we report the synthesis of a series of artificial oligonucleotides, d(5'-GH(n)C-3') (n = 1 to 5), with hydroxypyridone nucleobases (H) as flat bidentate ligands. Right-handed double helices of the oligonucleotides, nCu2+.d(5'-GH(n)C-3')2 (n = 1 to 5), were quantitatively formed through copper ion (Cu2+)-mediated alternative base pairing (H-Cu2+-H), where the Cu2+ ions incorporated into each complex were aligned along the helix axes inside the duplexes with the Cu2+-Cu2+ distance of 3.7 +/- 0.1 angstroms. The Cu2+ ions were coupled ferromagnetically with one another through unpaired d electrons to form magnetic chains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tanaka, Kentaro -- Tengeiji, Atsushi -- Kato, Tatsuhisa -- Toyama, Namiki -- Shionoya, Mitsuhiko -- New York, N.Y. -- Science. 2003 Feb 21;299(5610):1212-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Graduate School of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12595687" target="_blank"〉PubMed〈/a〉
Keywords:
Base Pairing
;
Circular Dichroism
;
Copper/*chemistry
;
DNA/*chemical synthesis/*chemistry
;
Electron Spin Resonance Spectroscopy
;
Electrons
;
Ligands
;
Magnetics
;
Nucleic Acid Conformation
;
Oligodeoxyribonucleotides/*chemical synthesis/*chemistry
;
Pyridones/chemistry
;
Spectrophotometry, Ultraviolet
;
Thermodynamics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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