Publication Date:
2002-05-23
Description:
Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peier, Andrea M -- Reeve, Alison J -- Andersson, David A -- Moqrich, Aziz -- Earley, Taryn J -- Hergarden, Anne C -- Story, Gina M -- Colley, Sian -- Hogenesch, John B -- McIntyre, Peter -- Bevan, Stuart -- Patapoutian, Ardem -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):2046-9. Epub 2002 May 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016205" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Animals, Newborn
;
Blotting, Northern
;
CHO Cells
;
Capsaicin/*analogs & derivatives/pharmacology
;
*Cation Transport Proteins
;
Cell Line
;
Cells, Cultured
;
Cloning, Molecular
;
Cricetinae
;
Epidermis/cytology/innervation/metabolism
;
Ganglia, Spinal/metabolism
;
*Hot Temperature
;
Humans
;
In Situ Hybridization
;
Ion Channels/chemistry/genetics/*metabolism
;
Keratinocytes/*metabolism
;
Membrane Potentials
;
Mice
;
Molecular Sequence Data
;
Nerve Endings/physiology
;
Neurons/physiology
;
Patch-Clamp Techniques
;
RNA, Messenger/genetics/metabolism
;
Ruthenium Red/pharmacology
;
Signal Transduction
;
Spinal Cord/metabolism
;
TRPV Cation Channels
;
Temperature
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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