ISSN:
0170-2041
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Preparation and Determination of the Configuration of xylo- and ribo-3′-S-Alkyl Derivatives of 2′-DeoxyadenosineThe syntheses of 2′-deoxy-3′-S-ethyl- (2), 2′-deoxy-3′-S-isopropyl- (3), and 2′-deoxy-3′-S-propyl-3′-thioadenosine (4) are described. Besides the xylo isomers 2a-4a the appropriate ribo isomers 2b-4b are formed as side products with a ratio of 6:1. The xylo configuration has been correlated to the main products 2a-4a according to the X-ray analysis of 2a which established the configuration.
Notes:
Die Synthesen von 2′-Desoxy-3′-S-ethyl- (2), 2′-Desoxy-3′-S-isopropyl- (3) und 2′-Desoxy-3′-S-propyl-3′-thioadenosin (4) werden beschrieben. Neben den xylo-Isomeren 2a-4a werden die entsprechenden ribo-Isomeren 2b-4b als Nebenprodukte im Verhältnis von 6:1 gebildet. Die xylo-Konfiguration konnte den Hauptprodukten 2a-4a durch Bestimmung der Konfiguration mittels Röntgenstrukturanalyse von 2a zugeordnet werden.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.198319830812
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