Publication Date:
2020-04-21
Description:
A detailed chemical analysis of a Philippine marine sponge Smenospongia sp. has been performed. This study yielded four new metabolites, 5-bromo-l-tryptophan (1), 5-bromoabrine (2), 5,6-dibromoabrine (3) and 5-bromoindole-3-acetic acid (4). The pyrroloiminoquinone alkaloid, makaluvamine O (5) as well as 5,6-dibromotryptamine (6), aureol (7) and furospinulosin 1 (8) were also isolated. Although 1 and 4 have been synthesized previously, this is the first report on the isolation of these compounds from a natural source. The furanosesterterpene
furospinulosin 1 (8) was obtained for the first time from the genus Smenospongia.
The structures of all compounds were established by spectroscopic methods (UV, IR,
1D and 2D NMR, MS, [α]D). The cytotoxic potential of 1Ð8 was evaluated in a panel of
isogenic HCT-116 human colon tumor cell lines.
Type:
Article
,
PeerReviewed
Format:
text
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