Publication Date:
2015-01-07
Description:
Article The nuclear protein TDP-43 is implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. Here, Cohen et al . discover lysine acetylation as a modification that regulates TDP-43 function, providing a mechanism that could be implicated in the pathogenesis of TDP-43 proteinopathies. Nature Communications doi: 10.1038/ncomms6845 Authors: Todd J. Cohen, Andrew W. Hwang, Clark R. Restrepo, Chao-Xing Yuan, John Q. Trojanowski, Virginia M. Y. Lee
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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