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  • 1
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    C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer (2013)
    Hindawi
    Details
    Publication Date: 2013-05-21
    Description: The prevalence of obesity has given rise to significant global concerns as numerous population-based studies demonstrate an incontrovertible association between obesity and breast cancer. Mechanisms proposed to account for this linkage include exaggerated levels of carbohydrate substrates, elevated levels of circulating mitogenic hormones, and inflammatory cytokines that impinge on epithelial programming in many tissues. Moreover, recently many scientists have rediscovered the observation, first described by Otto Warburg nearly a century ago, that most cancer cells undergo a dramatic metabolic shift in energy utilization and expenditure that fuels and supports the cellular expansion associated with malignant proliferation. This shift in substrate oxidation comes at the cost of sharp changes in the levels of the high energy intermediate, nicotinamide adenine dinucleotide (NADH). In this review, we discuss a novel example of how shifts in the concentration and flux of substrates metabolized and generated during carbohydrate metabolism represent components of a signaling network that can influence epigenetic regulatory events in the nucleus. We refer to this regulatory process as “metabolic transduction” and describe how the C-terminal binding protein (CtBP) family of NADH-dependent nuclear regulators represents a primary example of how cellular metabolic status can influence epigenetic control of cellular function and fate.
    Print ISSN: 1687-8876
    Electronic ISSN: 1687-8884
    Topics: Biology
    Published by Hindawi
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  • 2
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    C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer (2013)
    Hindawi
    Details
    Publication Date: 2013-01-01
    Description: The prevalence of obesity has given rise to significant global concerns as numerous population-based studies demonstrate an incontrovertible association between obesity and breast cancer. Mechanisms proposed to account for this linkage include exaggerated levels of carbohydrate substrates, elevated levels of circulating mitogenic hormones, and inflammatory cytokines that impinge on epithelial programming in many tissues. Moreover, recently many scientists have rediscovered the observation, first described by Otto Warburg nearly a century ago, that most cancer cells undergo a dramatic metabolic shift in energy utilization and expenditure that fuels and supports the cellular expansion associated with malignant proliferation. This shift in substrate oxidation comes at the cost of sharp changes in the levels of the high energy intermediate, nicotinamide adenine dinucleotide (NADH). In this review, we discuss a novel example of how shifts in the concentration and flux of substrates metabolized and generated during carbohydrate metabolism represent components of a signaling network that can influence epigenetic regulatory events in the nucleus. We refer to this regulatory process as “metabolic transduction” and describe how the C-terminal binding protein (CtBP) family of NADH-dependent nuclear regulators represents a primary example of how cellular metabolic status can influence epigenetic control of cellular function and fate.
    Print ISSN: 1687-8876
    Electronic ISSN: 1687-8884
    Topics: Biology
    Published by Hindawi
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  • 3
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    Effects of Asphalt Mix Design Properties on Pavement Performance: A Mechanistic Approach (2016)
    Hindawi
    Details
    Publication Date: 2016-01-01
    Description: The main objective of this study was to investigate the effects of hot mix asphalt material properties on the performance of flexible pavements via mechanistic approach. 3D Move Analysis software was utilized to determine rutting and cracking distresses in an asphalt concrete (AC) layer. Fourteen different Superpave mixes were evaluated by utilizing results of the Dynamic Modulus (|E⁎|) Test and the Dynamic Shear Modulus (|G⁎|) Test. Results showed that with the increase of binder content, the tendency of rutting in AC layer increased. However, with the increase of binder content, the cracking of AC layer lessened. Furthermore, when different binder grades were evaluated, results showed that with the increase of the upper binder grade number, rutting decreased, and with the increase of the lower binder grade number, rutting increased. Furthermore, analysis showed that with the increase of the lower binder grade number, higher percent of bottom up cracks would result. As a result of the analysis, binder grade should not be solely considered for cracking in AC layer; binder content and aggregate structure play a big role. Finally, results illustrated that the mechanistic approach is a better tool to determine the performance of asphalt pavement than commonly used methods.
    Print ISSN: 1687-8086
    Electronic ISSN: 1687-8094
    Topics: Architecture, Civil Engineering, Surveying
    Published by Hindawi
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  • 4
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    AQCQ-Functional Equation in Non-Archimedean Normed Spaces (2010)
    Hindawi
    Details
    Publication Date: 2010-01-01
    Description: We prove the generalized Hyers-Ulam stability of generalized mixed type of quartic, cubic, quadratic and additive functional equation in non-Archimedean spaces.
    Print ISSN: 1085-3375
    Electronic ISSN: 1687-0409
    Topics: Mathematics
    Published by Hindawi
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