Digitale Medien
Oxford, UK
:
Blackwell Publishing Ltd
International journal of immunogenetics
10 (1983), S. 0
ISSN:
1744-313X
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Biologie
,
Medizin
Notizen:
Previous work has shown that a cytotoxic T lymphocyte (CTL) immune response of syngeneic mice immunized with a chemically-induced BALB/c (H-2d) fibrosarcoma was directed against an individual tumour-associated antigen. To see whether this reaction was restricted by products of the major histocompatibility complex (MHC), anti-H-2 alloantisera to K or D antigens were used to interfere with the CTL-mediated immune response. Antisera to Kd but not to Dd antigens inhibited the lytic activity of CTL against fibrosarcoma cells. In addition, the study of the CTL response in F1→ P antitumour immunized chimeric mice showed that antitumour cytotoxicity developed only when F1 and parental host shared the Kd region. Both experiments strongly indicate that recognition of the individual tumour-associated antigen of the BALB/c fibrosarcoma is restricted by the products of H-2Kd genes.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1744-313X.1983.tb00812.x
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