ISSN:
0021-9304
Keywords:
basic fibroblast growth factor
;
heparin-like molecules
;
glucosyloxyethyl methacrylate (GEMA)
;
poly-(GEMA)-sulfate
;
hydrogel
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
Sulfated poly(glucosyloxyethyl methacrylate) [poly(GEMA)-sulfate] and its hydrogel were synthesized and evaluated to develop novel tissue regeneration assist devices. The poly(GEMA)-sulfate hydrogel was obtained by γ-ray irradiation. Basic fibroblast growth factor (bFGF) was expected to be subsequently incorporated with hydrogel matrices and activated or released from the matrices. A sustained release of bFGF from the poly(GEMA)-sulfate hydrogel was not realized; however, bFGF from poly(GEMA)-sulfate hydrogel was effectively activated. Poly(GEMA)-sulfate hydrogels are thought to be potential component materials for a tissue engineering matrix. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 386-391, 1998.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
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