Publication Date:
1996-07-12
Description:
Circulating lymphocytes gain access to lymph nodes owing to their ability to initiate rolling along specialized high endothelial venules (HEVs). One mechanism of rolling involves L-selectin binding to peripheral node addressin (PNAd) on HEVs. Activated platelets are shown to bind to circulating lymphocytes and to mediate rolling in HEVs, in vivo, through another molecule, P-selectin, which also interacts with PNAd. In vitro, activated platelets enhanced tethering of lymphocytes to PNAd and sustained lymphocyte rolling, even in the absence of functional L-selectin. Thus, a platelet pathway operating through P-selectin provides a second mechanism for lymphocyte delivery to HEVs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diacovo, T G -- Puri, K D -- Warnock, R A -- Springer, T A -- von Andrian, U H -- HL48675/HL/NHLBI NIH HHS/ -- HL54936/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1996 Jul 12;273(5272):252-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Blood Research, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662511" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Surface/*metabolism
;
Blood Platelets/*physiology
;
Cell Adhesion
;
Cell Movement
;
Endothelium, Vascular/cytology
;
Humans
;
L-Selectin/physiology
;
Ligands
;
Lymph Nodes/*blood supply/cytology
;
Lymphocytes/cytology/*physiology
;
Membrane Glycoproteins/metabolism
;
Membrane Proteins
;
Mice
;
P-Selectin/metabolism
;
Platelet Activation
;
Receptors, Lymphocyte Homing/metabolism
;
Transfection
;
Tumor Cells, Cultured
;
Venules/cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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