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  • 1
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    A gene-coexpression network for global discovery of conserved genetic modules (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-08-23
    Description: To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexpression of these gene pairs confers a selective advantage and therefore that these genes are functionally related. Many of these relationships provide strong evidence for the involvement of new genes in core biological functions such as the cell cycle, secretion, and protein expression. We experimentally confirmed the predictions implied by some of these links and identified cell proliferation functions for several genes. By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stuart, Joshua M -- Segal, Eran -- Koller, Daphne -- Kim, Stuart K -- New York, N.Y. -- Science. 2003 Oct 10;302(5643):249-55. Epub 2003 Aug 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford Medical Informatics, 251 Campus Drive, Medical School Office Building X-215, Stanford, CA 94305-5329, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12934013" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Caenorhabditis elegans/genetics ; Cell Cycle/genetics ; Cell Division/genetics ; Computational Biology ; Conserved Sequence ; Databases, Genetic ; Drosophila melanogaster/genetics ; *Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation ; Genes, Fungal ; Genes, Helminth ; Genes, Insect ; Humans ; Models, Statistical ; Mutation ; *Oligonucleotide Array Sequence Analysis ; Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Signal Transduction/genetics ; Species Specificity ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Reading the worm genome (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, S K -- New York, N.Y. -- Science. 2000 Jan 7;287(5450):52-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, CA 94305-5329, USA. kim@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10644223" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/*genetics/growth & development/*metabolism ; *Caenorhabditis elegans Proteins ; Female ; Genes, Helminth ; *Genome ; Helminth Proteins/genetics/*metabolism ; Protein Binding ; Repressor Proteins/genetics/metabolism ; Retinoblastoma Protein/metabolism ; Signal Transduction ; *Two-Hybrid System Techniques ; Vulva/growth & development ; Yeasts/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A gene expression map for Caenorhabditis elegans (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-15
    Description: We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, S K -- Lund, J -- Kiraly, M -- Duke, K -- Jiang, M -- Stuart, J M -- Eizinger, A -- Wylie, B N -- Davidson, G S -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2087-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA. kim@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557892" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Caenorhabditis elegans/*genetics/physiology ; *Computational Biology ; DNA Transposable Elements ; DNA, Complementary ; Databases, Factual ; Female ; *Gene Expression ; *Gene Expression Profiling ; Gene Expression Regulation ; *Genes, Helminth ; Genome ; *Genomics ; Helminth Proteins/biosynthesis/genetics ; Intestines/physiology ; Male ; Muscles/physiology ; Neurons/physiology ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis ; Oocytes/physiology ; RNA, Helminth/genetics ; Software ; Spermatozoa/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-11
    Description: In the fruit fly Drosophila, four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain. Here, we show that ablation of these IPCs causes developmental delay, growth retardation, and elevated carbohydrate levels in larval hemolymph. All of the defects were reversed by ectopic expression of a Drosophila insulin transgene. On the basis of these functional data and the observation that IPCs release insulin into the circulatory system, we conclude that brain IPCs are the main systemic supply of insulin during larval growth. We propose that IPCs and pancreatic islet beta cells are functionally analogous and may have evolved from a common ancestral insulin-producing neuron. Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rulifson, Eric J -- Kim, Seung K -- Nusse, Roel -- New York, N.Y. -- Science. 2002 May 10;296(5570):1118-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305-5329, USA. rulifson@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Blood Glucose/*metabolism ; Brain/cytology ; Cell Count ; Cell Size ; Diabetes Mellitus ; Drosophila/anatomy & histology/genetics/growth & development/*physiology ; Drosophila Proteins/genetics/*metabolism ; Gene Expression ; Heart/innervation ; Hemolymph ; Insect Hormones/genetics/metabolism ; Insulin/genetics/*metabolism ; Larva/growth & development ; Myocardium/metabolism ; Neurons/*metabolism ; Neurosecretory Systems/cytology/metabolism ; Oligopeptides/genetics/metabolism ; Phenotype ; Pyrrolidonecarboxylic Acid/analogs & derivatives ; RNA, Messenger/genetics/metabolism ; Transgenes ; Trehalose/*blood ; Wings, Animal/anatomy & histology/cytology/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of magnetic field on the electrodeposition of Fe, Co into the pores of anodic film on aluminum (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 6185-6187 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Ferromagnetic Fe or Co was electrodeposited into the pores in aluminum anodic oxide film to produce a magnetic anodic film, and the effects of magnetic field during electrodeposition on the deposition characteristics of the metals and coercivity of the produced anodic film were investigated. Fe was electrodeposited into the pores in anodic film using a mixed solution (pH=3.8) of FeSO4(NH4)SO4.6H2O (0.20 mol/l) and H3BO4 (0.48 mol/l) at 20 °C with constant applied voltage of 10 V, and Co using a mixed solution (pH=4.5) of CoSO4,7H2O (0.10 mol/l) and H3BO4 (0.48 mol/l). It has been found that for the Fe-deposited anodic film the coercivity increased with increasing length of deposited Fe particles and decreased with increasing diameter (or porosity). The application of magnetic field during electrodeposition of Fe had little influence on the coercivity of the anodic film. For the Co-deposited anodic film the coercivity increased with increasing length of deposited Fe particles and increased unexpectedly with increasing diameter. The perpendicular coercivity of the Co-deposited anodic film was significantly increased by the application of magnetic field during the electrodeposition. The unexpected coercivity increase with diameter and the increase of the perpendicular coercivity of Co-deposited film by the application of magnetic field were closely related to the preferred orientation of Co crystals in the anodic film. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372650
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  • 6
    Electronic Resource
    Electronic Resource
    Improvement of maize populations for resistance to downy mildew (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 122 (2003), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Upgrading levels of disease resistance are a primary objective of maize breeding programmes. Efficacy of S1 recurrent selection in improving levels of resistance to downy mildew (DM) infection was assessed in Nigeria from 1997 to 2000 in six maize populations. Improvement procedures consisted of evaluating S1 progenies under artificial infection with DM spores and in disease-free environments and using a selection index to combine selection for reduced DM infection with appropriate agronomic characters from more than one environment. Three to four cycles of selection were completed in each of the populations. Products from the different cycles of selection were evaluated and data collected on DM infection parameters and agronomic traits. Result obtained showed 3–4 cycles of selection were adequate to reduce DM infection levels significantly and increase grain yield. Downy mildew infection decreased by between 58 and 100% while grain yield increases ranged from 10 to 98% for the 2-4 cycles of selection relative to the C0 (original). Selection increased grain yield with acceptable changes in plant height while maintaining maturity in disease-free environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2003.00867.x
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of Chlorella powder as a feed additive on growth performance in juvenile Korean rockfish, Sebastes schlegeli (Hilgendorf) (2001)
    Oxford, UK : Blackwell Science, Ltd
    Aquaculture research 32 (2001), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The present study was conducted to investigate the effects of Chlorella powder (CHP) as a feed additive on growth performance in juvenile Korean rockfish, Sebastes schlegeli (Hilgendorf). Six experimental diets were supplemented with Chlorella powder (CHP) at 0, 0.5, 1.0, 1.5, 2.0 and 4.0% (CHP0, CHP0.5, CHP1.0, CHP1.5, CHP2.0 and CHP4.0, respectively) of diet as a dry matter basis. Three replicate groups of fish averaging 2.1 ± 0.02 g (mean ± SD) were fed one of six experimental diets for 12 weeks. After the feeding trial, fish fed CHP0.5 had a higher weight gain and specific growth rate than did fish fed CHP0, CHP1.5, CHP2.0 and CHP4.0. However, there was no significant difference among fish fed CHP0.5 and CHP1.0. Fish fed CHP0.5 had a significantly higher feed efficiency ratio and a protein efficiency ratio than did fish fed the other diets. Fish fed CHP4.0 had a lower significantly serum total lipid than did fish fed CHP0, CHP0.5 and CHP1.0, however, there was no significant difference among fish fed CHP1.5, CHP2.0 and CHP4.0. Fish fed CHP2.0 had significantly higher serum albumin and lower serum glucose than did fish fed CHP0. Fish fed CHP4.0 had significantly higher liver protein and lower liver fat than did fish fed the other diets. These results suggest that the optimum dietary CHP supplementation level could be approximately 0.5% of diet for positive effects on growth and feed utilization without any negative effects on blood parameters and body composition in juvenile Korean rockfish.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1355-557x.2001.00008.x
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  • 8
    Electronic Resource
    Electronic Resource
    Experimental Techniques and Identification of Nonlinear and Viscoelastic Properties of Flexible Polyurethane Foam (2000)
    Springer
    Nonlinear dynamics 22 (2000), S. 281-313 
    Details
    ISSN: 1573-269X
    Keywords: viscoelasticity ; harmonic balance ; foam ; nonlinear ; system identification ; polynomial stiffness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Identification of the vibrational behavior of polyurethanefoams used in automotive seats is described. The dynamic system consistsof a rigid block mounted on a 3″ cube of foam material, which serves asthe only flexible component. When constrained to undergo linearunidirectional motion, the dynamic system is modeled as a single degreeof freedom system, governed by an integro-differential equation. Inaddition to a relaxation kernel representing the linear viscoelasticbehavior of the foam, the model includes a polynomial type stiffness toaccount for the foam's strain-based nonlinearities. The relaxationkernel is assumed to be of an exponential type. Experimentalmethodologies for obtaining repeatable, accurate measurements of thesystem's response to an impulse and to single frequency harmonic baseexcitations are described. Analysis methods are then investigated forextracting the relevant linear, nonlinear, and viscoelastic parameters.Characterization of these foam properties as functions of compressionlevel is also presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008302208269
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  • 9
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    Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans (2001)
    National Academy of Sciences
    Details
    Publication Date: 2001-01-02
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells (2004)
    National Academy of Sciences
    Details
    Publication Date: 2004-09-20
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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