Publication Date:
2000-04-01
Description:
Mechanosensory transduction underlies a wide range of senses, including proprioception, touch, balance, and hearing. The pivotal element of these senses is a mechanically gated ion channel that transduces sound, pressure, or movement into changes in excitability of specialized sensory cells. Despite the prevalence of mechanosensory systems, little is known about the molecular nature of the transduction channels. To identify such a channel, we analyzed Drosophila melanogaster mechanoreceptive mutants for defects in mechanosensory physiology. Loss-of-function mutations in the no mechanoreceptor potential C (nompC) gene virtually abolished mechanosensory signaling. nompC encodes a new ion channel that is essential for mechanosensory transduction. As expected for a transduction channel, D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanosensory organs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, R G -- Willingham, A T -- Zuker, C S -- 5T32GM08107/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Mar 24;287(5461):2229-34.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Howard Hughes Medical Institute, University of California, San Diego,CA 92093-0649, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10744543" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Adaptation, Physiological
;
Amino Acid Sequence
;
Animals
;
Caenorhabditis elegans/genetics/physiology
;
Chromosome Mapping
;
Cloning, Molecular
;
Dendrites/physiology
;
*Drosophila Proteins
;
Drosophila melanogaster/genetics/*physiology
;
Gene Expression Profiling
;
Genes, Insect
;
Hair Cells, Auditory/physiology
;
Insect Proteins/chemistry/genetics/physiology
;
Ion Channels/chemistry/*genetics/*physiology
;
Mechanoreceptors/*physiology
;
Molecular Sequence Data
;
Mutation
;
Neurons, Afferent/*physiology
;
Patch-Clamp Techniques
;
Physical Stimulation
;
Proprioception
;
Sensation/physiology
;
Sense Organs/physiology
;
Signal Transduction
;
Touch
;
Transient Receptor Potential Channels
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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