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  • 1
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    Applications of Correlation Gas Chromatography and Transpiration Studies for the Evaluation of the Vaporization and Sublimation Enthalpies of Some Perfluorinated Hydrocarbons (2012)
    American Chemical Society (ACS)
    Details
    Publication Date: 2012-07-14
    Description: Journal of Chemical & Engineering Data DOI: 10.1021/je300504f
    Print ISSN: 0021-9568
    Electronic ISSN: 1520-5134
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society (ACS)
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  • 2
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    Antarctic influences on Late Pliocene cooling [Earth, Atmospheric, and Planetary Sciences] (2012)
    National Academy of Sciences
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    Publication Date: 2012-04-25
    Description: The influence of Antarctica and the Southern Ocean on Late Pliocene global climate reconstructions has remained ambiguous due to a lack of well-dated Antarctic-proximal, paleoenvironmental records. Here we present ice sheet, sea-surface temperature, and sea ice reconstructions from the ANDRILL AND-1B sediment core recovered from beneath the Ross Ice Shelf. We provide evidence for a major expansion of an ice sheet in the Ross Sea that began at ∼3.3 Ma, followed by a coastal sea surface temperature cooling of ∼2.5 °C, a stepwise expansion of sea ice, and polynya-style deep mixing in the Ross Sea between 3.3 and 2.5 Ma. The intensification of Antarctic cooling resulted in strengthened westerly winds and invigorated ocean circulation. The associated northward migration of Southern Ocean fronts has been linked with reduced Atlantic Meridional Overturning Circulation by restricting surface water connectivity between the ocean basins, with implications for heat transport to the high latitudes of the North Atlantic. While our results do not exclude low-latitude mechanisms as drivers for Pliocene cooling, they indicate an additional role played by southern high-latitude cooling during development of the bipolar world.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Dual character of excited charge carriers in graphene on Ni(111) (2014)
    American Physical Society (APS)
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    Publication Date: 2014-02-08
    Description: Author(s): L. Bignardi, T. Haarlammert, C. Winter, M. Montagnese, P. H. M. van Loosdrecht, E. Voloshina, P. Rudolf, and H. Zacharias The dynamics of excited charge carriers at the graphene/Ni(111) interface has been investigated by means of time-resolved two-photon photoemission spectroscopy, employing femtosecond-XUV pulses with an energy of 39.2 eV produced by high-order-harmonic generation. Due to the interplay of substrate an... [Phys. Rev. B 89, 075405] Published Fri Feb 07, 2014
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    With or against the tide: The influence of bed form asymmetry on the formation of macroturbulence and suspended sediment patterns (2014)
    Wiley
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    Publication Date: 2014-09-10
    Description: This study examines tide-dependent variations in the formation and dynamics of suspended sediment patterns coupled to mean flow and turbulence above asymmetric bedforms. In the Danish Knudedyb inlet, very large primary bedforms remain ebb-oriented during a tidal cycle while smaller superimposed bedforms reverse direction with each tidal phase. Hydro-acoustic in-situ observations reveal pronounced differences in suspended sediment transport patterns between tidal phases caused by the relative orientation of primary bedforms and the mean tidal flow and flow unsteadiness during a single tidal phase. When flow and primary bedform orientation are aligned, water-depth-scale macroturbulence develops in the bedform lee-sides in the presence of flow separation. Macroturbulent flow structures occur at high flow stages and are coupled to increased amounts of sediment in suspension. When flow and bedform orientation are opposed no evidence of flow separation associated with primary bedforms is found. Sediment-laden macroturbulence at high flow velocities is of a smaller scale and attributed to the superimposed secondary bedforms. The flow structures are advected along the primary bedform stoss-side (temporary hydraulic lee-side). The steep primary bedform lee-side (temporary hydraulic stoss-side) however, limits transport capabilities beyond the scale of primary bedforms.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    How many of the observed neutrino events can be described by cosmic ray interactions in the Milky Way? (2014)
    Oxford University Press
    Details
    Publication Date: 2014-03-25
    Description: Cosmic rays diffuse through the interstellar medium and interact with matter and radiations as long as they are trapped in the Galactic magnetic field. The IceCube experiment has detected some TeV–PeV neutrino events whose origin is yet unknown. We study if all or a fraction of these events can be described by the interactions of cosmic rays with matter. We consider the average target density needed to explain them for different halo sizes and shapes, the effect of the chemical composition of the cosmic rays, the impact of the directional information of the neutrino events, and the constraints from gamma-ray bounds and their direction. We do not require knowledge of the cosmic ray escape time or injection for our approach. We find that, given all constraints, at most 0.1 of the observed neutrino events in IceCube can be described by cosmic ray interactions with matter. In addition, we demonstrate that the currently established chemical composition of the cosmic rays contradicts a peak of the neutrino spectrum at PeV energies.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 6
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    Erratum: 'How many of the observed neutrino events can be described by cosmic ray interactions in the Milky Way?' (2014)
    Oxford University Press
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    Publication Date: 2014-11-15
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 7
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    Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-02
    Description: Prenatal infection and exposure to traumatizing experiences during peripuberty have each been associated with increased risk for neuropsychiatric disorders. Evidence is lacking for the cumulative impact of such prenatal and postnatal environmental challenges on brain functions and vulnerability to psychiatric disease. Here, we show in a translational mouse model that combined exposure to prenatal immune challenge and peripubertal stress induces synergistic pathological effects on adult behavioral functions and neurochemistry. We further demonstrate that the prenatal insult markedly increases the vulnerability of the pubescent offspring to brain immune changes in response to stress. Our findings reveal interactions between two adverse environmental factors that have individually been associated with neuropsychiatric disease and support theories that mental illnesses with delayed onsets involve multiple environmental hits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giovanoli, Sandra -- Engler, Harald -- Engler, Andrea -- Richetto, Juliet -- Voget, Mareike -- Willi, Roman -- Winter, Christine -- Riva, Marco A -- Mortensen, Preben B -- Feldon, Joram -- Schedlowski, Manfred -- Meyer, Urs -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1095-9. doi: 10.1126/science.1228261.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiology and Behavior Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, 8603 Schwerzenbach, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytokines/immunology ; Disease Models, Animal ; Female ; Humans ; Mental Disorders/*immunology ; Mice ; Mice, Inbred C57BL ; Poly I-C/immunology/pharmacology ; Pregnancy ; Prenatal Exposure Delayed Effects/*immunology/virology ; Puberty/*immunology ; Stress, Physiological/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Integrative genomics identifies LMO1 as a neuroblastoma oncogene (2010)
    Nature Publishing Group (NPG)
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    Publication Date: 2010-12-03
    Description: Neuroblastoma is a childhood cancer of the sympathetic nervous system that accounts for approximately 10% of all paediatric oncology deaths. To identify genetic risk factors for neuroblastoma, we performed a genome-wide association study (GWAS) on 2,251 patients and 6,097 control subjects of European ancestry from four case series. Here we report a significant association within LIM domain only 1 (LMO1) at 11p15.4 (rs110419, combined P = 5.2 x 10(-16), odds ratio of risk allele = 1.34 (95% confidence interval 1.25-1.44)). The signal was enriched in the subset of patients with the most aggressive form of the disease. LMO1 encodes a cysteine-rich transcriptional regulator, and its paralogues (LMO2, LMO3 and LMO4) have each been previously implicated in cancer. In parallel, we analysed genome-wide DNA copy number alterations in 701 primary tumours. We found that the LMO1 locus was aberrant in 12.4% through a duplication event, and that this event was associated with more advanced disease (P 〈 0.0001) and survival (P = 0.041). The germline single nucleotide polymorphism (SNP) risk alleles and somatic copy number gains were associated with increased LMO1 expression in neuroblastoma cell lines and primary tumours, consistent with a gain-of-function role in tumorigenesis. Short hairpin RNA (shRNA)-mediated depletion of LMO1 inhibited growth of neuroblastoma cells with high LMO1 expression, whereas forced expression of LMO1 in neuroblastoma cells with low LMO1 expression enhanced proliferation. These data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320515/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320515/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Kai -- Diskin, Sharon J -- Zhang, Haitao -- Attiyeh, Edward F -- Winter, Cynthia -- Hou, Cuiping -- Schnepp, Robert W -- Diamond, Maura -- Bosse, Kristopher -- Mayes, Patrick A -- Glessner, Joseph -- Kim, Cecilia -- Frackelton, Edward -- Garris, Maria -- Wang, Qun -- Glaberson, Wendy -- Chiavacci, Rosetta -- Nguyen, Le -- Jagannathan, Jayanti -- Saeki, Norihisa -- Sasaki, Hiroki -- Grant, Struan F A -- Iolascon, Achille -- Mosse, Yael P -- Cole, Kristina A -- Li, Hongzhe -- Devoto, Marcella -- McGrady, Patrick W -- London, Wendy B -- Capasso, Mario -- Rahman, Nazneen -- Hakonarson, Hakon -- Maris, John M -- 9024/Cancer Research UK/United Kingdom -- R00 CA151869/CA/NCI NIH HHS/ -- R01 CA124709/CA/NCI NIH HHS/ -- R01 CA124709-05/CA/NCI NIH HHS/ -- R01-CA124709/CA/NCI NIH HHS/ -- U10-CA98413/CA/NCI NIH HHS/ -- U10-CA98543/CA/NCI NIH HHS/ -- UL1-RR024134-03/RR/NCRR NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2011 Jan 13;469(7329):216-20. doi: 10.1038/nature09609. Epub 2010 Dec 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21124317" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Cell Line, Tumor ; Cell Proliferation ; Chromosomes, Human, Pair 11/genetics ; DNA Copy Number Variations/genetics ; DNA-Binding Proteins/*genetics ; Disease Progression ; Europe/ethnology ; Gene Duplication/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; *Genome-Wide Association Study ; Genomics ; Genotype ; Humans ; LIM Domain Proteins ; Neuroblastoma/*genetics/pathology ; Odds Ratio ; Oncogenes/*genetics ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Survival Rate ; Transcription Factors/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Analysis of 25 mutual eclipses and occultations between the Galilean satellites observed from Brazil in 2009 (2013)
    Oxford University Press
    Details
    Publication Date: 2013-05-21
    Description: The light curves of mutual eclipses and occultations between the natural satellites of a planet allow us to obtain high-precision position and relative motion from differential photometry, enough to detect weak orbital disturbing forces, such as tidal forces. The observations are made during the equinoxes of the planet. We studied 25 light curves observed in Brazil during the 2009 campaign of the Galilean satellites’ mutual phenomena. A narrow-band filter centred at 890 nm was used, strongly attenuating the Jupiter's scattered light. We fitted the occultation and eclipse light curves using semi-analytical models that take into account the gradual decrease of light over the shadow, the solar limb darkening and the solar phase angle. The Oren–Nayar reflexive model was used to map the inhomogeneous light scattering on the surface of the satellites. For the first time it is used in a work about mutual events. Here, we include the study that made us decide for this model. We measured the impact parameter, relative velocity and central instant with average precisions of 7.46 km (2.2 mas), 0.08 km s –1 (0.02 mas s –1 ) and 0.42 s (6.13 km), respectively. The fit precision of the normalized light-curve fluxes ranged between 0.4 and 4.4 per cent.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 10
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    Wind extremes in the North Sea basin under climate change: an ensemble study of 12 CMIP5 GCMs (2013)
    Wiley
    Details
    Publication Date: 2013-01-18
    Description: [1]  Coastal safety may be influenced by climate change, as changes in extreme surge levels and wave extremes may increase the vulnerability of dunes and other coastal defenses. In the North Sea, an area already prone to severe flooding, these high surge levels and waves are generated by low atmospheric pressure and severe wind speeds during storm events. As a result of the geometry of the North Sea, not only the maximum wind speed is relevant, but also wind direction. Climate change could change maximum wind conditions, with potentially negative effects for coastal safety. Here, we use an ensemble of 12 CMIP5 GCMs and diagnose the effect of two climate scenarios (rcp4.5 and rcp8.5) on annual maximum wind speed, wind speeds with lower return frequencies and the direction of these annual maximum wind speeds. The 12 selected CMIP5 models do not project changes in annual maximum wind speed and in wind speeds with lower return frequencies; however, we do find an indication that the annual extreme wind events are coming more often from western directions. Our results are in line with the studies based on CMIP3 models and do not confirm the statement based on some reanalysis studies that there is a climate-change related upward trend in storminess in the North Sea area.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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