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  • 1
    Monograph available for loan
    Monograph available for loan
    Groundwater in fractured bedrock environments : managing catchment and subsurface resources (2019)
    London : Geological Society
    Associated volumes
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    Call number: 9/M 07.0421(479)
    In: Geological Society Special Publication, 479
    Description / Table of Contents: Fractured bedrock aquifers have traditionally been regarded as low-productivity aquifers, with only limited relevance to regional groundwater resources. It is now being increasingly recognised that these complex bedrock aquifers can play an important role in catchment management and subsurface energy systems. At shallow to intermediate depth, fractured bedrock aquifers help to sustain surface water baseflows and groundwater dependent ecosystems, provide local groundwater supplies and impact on contaminant transfers on a catchment scale. At greater depths, understanding the properties and groundwater flow regimes of these complex aquifers can be crucial for the successful installation of subsurface energy and storage systems, such as deep geothermal or Aquifer Thermal Energy Storage systems and natural gas or CO2 storage facilities as well as the exploration of natural resources such as conventional/unconventional oil and gas. In many scenarios, a robust understanding of fractured bedrock aquifers is required to assess the nature and extent of connectivity between such engineered subsurface systems at depth and overlying receptors in the shallow subsurface.
    Type of Medium: Monograph available for loan
    Pages: 250 Seiten , Illustrationen
    ISBN: 978-1-78620-401-1
    ISSN: 0305-8719 (Print) , 2041-4927 (ebook)
    Series Statement: Geological Society Special Publication 479
    URL: https://sp.lyellcollection.org/content/479/1
    Language: English
    Note: Contents OFTERDINGER, U., MACDONALD, A. M., COMTE, J.-C. & YOUNG, M. E. Groundwater in fracturedbedrock environments: managing catchment and subsurface resources–an introduction .....1 FOUCHÉ, O., YAO,TH. K., OGA, M.-S. Y. & SORO, N. Typology of hard rock ground waterswithin the Lower Sassandra, a main catchment in humid tropical West Africa .....................................11 COMTE, J.-C., OFTERDINGER, U., LEGCHENKO, A., CAULFIELD, J., CASSIDY,R.&MÉZQUITAGONZÁLEZ, J. A. Catchment-scale heterogeneity offlow and storage propertiesin a weathered/fractured hard rock aquifer from resistivity and magnetic resonance surveys: implications for groundwaterflow paths and the distribution of residence times ........................................................................35 VASSEUR,G.&LACHASSAGNE, P. Evaluation of the geothermal effects caused by the weatheringof crystalline rocks ....................59 MACDONALD,A.M.&DAVIES, J. Fractures in shale: the significance of igneous intrusions forgroundwaterflow .....................................71 DICKSON, N. E. M., COMTE, J.-C., KOUSSOUBE, Y., OFTERDINGER,U.S.&VOUILLAMOZ, J.-M.Analysis and numerical modelling of large-scale controls on aquifer structure andhydrogeological properties in the African basement (Benin, West Africa) .....................................................................................81 PARKER, B. L., CHAPMAN, S. W., GOLDSTEIN,K.J.&CHERRY, J. A. Multiple lines offieldevidence to inform fracture network connectivity at a shale site contaminated with densenon-aqueous phase liquids ..........................................................................101 STROEBEL, D. H., THIART,C.&DEWIT, M. Towards defining a baseline status of scarcegroundwater resources in anticipation of hydraulic fracturing in the Eastern Cape Karoo,South Africa: salinity, aquifer yields and groundwater levels ........................................129 BAIOCCHI, A., LOTTI, F., PISCOPO,V.&SAMMASSIMO, V. Hard-rock aquifer response topumping and sustainable yield of wells in some areas of Mediterranean Region ........................................147 NEWTON, C. J. Fracture and conduit controls on groundwater movementin the Carboniferous Limestone of the eastern Mendip Hills, Somerset, England .........................................................161 KENNEL,J.R.&PARKER, B. L. Acoustic televiewer amplitude data for porosity estimationwith application to porewater conversion ....177 BELLE, P., LACHASSAGNE, P., MATHIEU, F., BARBET, C., BRISSET,N.&GOURRY, J.-C.Characterization and location of the laminated layer within hard rock weathering profilesfrom electrical resistivity tomography: implications for water well siting ..............187 PARKER, B. L., BAIROS, K., MALDANER, C. H., CHAPMAN, S. W., TURNER, C. M.,BURNS, L. S., PLETT, J., CARTER, R.&CHERRY, J. A. Metolachlor dense non-aqueous phaseliquid source conditions and plume attenuation in a dolostone water supply aquifer ................................................................207 ADEKILE,D.&CARTER, R. James Robert Temple Hazell: A Pioneer of African Hydrogeology ...........................................................237 Index .....................................................................................245
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  • 2
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    Groundwater in Fractured Bedrock Environments : Managing Catchment and Subsurface Resources (2019)
    London : The Geological Society
    Details
    Keywords: fractured bedrock ; aquifers ; groundwater
    Description / Table of Contents: Groundwater in fractured bedrock environments: managing catchment and subsurface resources – an introduction / U. Ofterdinger, A. M. MacDonald, J.-C. Comte and M. E. Young / Geological Society, London, Special Publications, 479, 1-9, 30 April 2019, https://doi.org/10.1144/SP479-2018-170 --- Typology of hard rock ground waters within the Lower Sassandra, a main catchment in humid tropical West Africa / O. Fouché, Th. K. Yao, M.-S. Y. Oga and N. Soro / Geological Society, London, Special Publications, 479, 11-33, 21 May 2018, https://doi.org/10.1144/SP479.5 --- Catchment-scale heterogeneity of flow and storage properties in a weathered/fractured hard rock aquifer from resistivity and magnetic resonance surveys: implications for groundwater flow paths and the distribution of residence times / J.-C. Comte, U. Ofterdinger, A. Legchenko, J. Caulfield, R. Cassidy and J. A. Mézquita González / Geological Society, London, Special Publications, 479, 35-58, 10 May 2018, https://doi.org/10.1144/SP479.11 --- Evaluation of the geothermal effects caused by the weathering of crystalline rocks / Guy Vasseur and Patrick Lachassagne / Geological Society, London, Special Publications, 479, 59-70, 8 May 2018, https://doi.org/10.1144/SP479.1 --- Fractures in shale: the significance of igneous intrusions for groundwater flow / Alan M. MacDonald and Jeff Davies / Geological Society, London, Special Publications, 479, 71-79, 17 April 2018, https://doi.org/10.1144/SP479.10 --- Analysis and numerical modelling of large-scale controls on aquifer structure and hydrogeological properties in the African basement (Benin, West Africa) / Neil E. M. Dickson, Jean-Christophe Comte, Youssouf Koussoube, Ulrich S. Ofterdinger and Jean-Michel Vouillamoz / Geological Society, London, Special Publications, 479, 81-100, 8 May 2018, https://doi.org/10.1144/SP479.2 --- Multiple lines of field evidence to inform fracture network connectivity at a shale site contaminated with dense non-aqueous phase liquids / Beth L. Parker, Steven W. Chapman, Kenneth J. Goldstein and John A. Cherry / Geological Society, London, Special Publications, 479, 101-127, 17 April 2018, https://doi.org/10.1144/SP479.8 --- Towards defining a baseline status of scarce groundwater resources in anticipation of hydraulic fracturing in the Eastern Cape Karoo, South Africa: salinity, aquifer yields and groundwater levels / Divan H. Stroebel, Christien Thiart and Maarten de Wit / Geological Society, London, Special Publications, 479, 129-145, 8 May 2018, https://doi.org/10.1144/SP479.3 --- Hard-rock aquifer response to pumping and sustainable yield of wells in some areas of Mediterranean Region / Antonella Baiocchi, Francesca Lotti, Vincenzo Piscopo and Valentina Sammassimo / Geological Society, London, Special Publications, 479, 147-160, 28 March 2018, https://doi.org/10.1144/SP479.4 --- Fracture and conduit controls on groundwater movement in the Carboniferous Limestone of the eastern Mendip Hills, Somerset, England / Christopher J. Newton / Geological Society, London, Special Publications, 479, 161-176, 25 April 2019, https://doi.org/10.1144/SP479-2017-52 --- Acoustic televiewer amplitude data for porosity estimation with application to porewater conversion / J. R. Kennel and B. L. Parker / Geological Society, London, Special Publications, 479, 177-185, 3 May 2018, https://doi.org/10.1144/SP479.6 --- Characterization and location of the laminated layer within hard rock weathering profiles from electrical resistivity tomography: implications for water well siting / Pierre Belle, Patrick Lachassagne, Francis Mathieu, Christine Barbet, Nicolas Brisset and Jean-Christophe Gourry / Geological Society, London, Special Publications, 479, 187-205, 8 May 2018, https://doi.org/10.1144/SP479.7 --- Metolachlor dense non-aqueous phase liquid source conditions and plume attenuation in a dolostone water supply aquifer / Beth L. Parker, Kenley Bairos, Carlos H. Maldaner, Steven W. Chapman, Christopher M. Turner, Leanne S. Burns, James Plett, Raymond Carter and John A. Cherry / Geological Society, London, Special Publications, 479, 207-236, 21 May 2018, https://doi.org/10.1144/SP479.9 --- James Robert Temple Hazell: A Pioneer of African Hydrogeology / Dotun Adekile and Richard Carter / Geological Society, London, Special Publications, 479, 237-243, 15 October 2018, https://doi.org/10.1144/SP479.12
    Pages: Online-Ressource (250 Seiten) , Illustrationen, Diagramme
    ISBN: 9781786204011
    URL: https://sp.lyellcollection.org/content/479/1
    Language: English
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  • 3
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    Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Description: 〈p〉In contrast to other B-cell antigen receptor (BCR) classes, the function of IgD BCR on mature B cells remains largely elusive as mature B cells co-express IgM, which is sufficient for development, survival, and activation of B cells. Here, we show that IgD expression is regulated by the forkhead box transcription factor FoxO1, thereby shifting the responsiveness of mature B cells towards recognition of multivalent antigen. FoxO1 is repressed by phosphoinositide 3-kinase (PI3K) signaling and requires the lipid phosphatase Pten for its activation. Consequently, Pten-deficient B cells expressing knock-ins for BCR 〈i〉heavy〈/i〉 and 〈i〉light chain〈/i〉 genes are unable to upregulate IgD. Furthermore, in the presence of autoantigen, Pten-deficient B cells cannot eliminate the autoreactive BCR specificity by secondary 〈i〉light chain〈/i〉 gene recombination. Instead, Pten-deficient B cells downregulate BCR expression and become unresponsive to further BCR-mediated stimulation. Notably, we observed a delayed germinal center (GC) reaction by IgD-deficient B cells after immunization with trinitrophenyl-ovalbumin (TNP-Ova), a commonly used antigen for T-cell-dependent antibody responses. Together, our data suggest that the activation of IgD expression by Pten/FoxO1 results in mature B cells that are selectively responsive to multivalent antigen and are capable of initiating rapid GC reactions and T-cell-dependent antibody responses.〈/p〉
    Print ISSN: 0261-4189
    Electronic ISSN: 1460-2075
    Topics: Biology , Medicine
    Published by Springer Nature on behalf of The European Molecular Biology Organization (EMBO).
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  • 4
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    Groundwater in Fractured Bedrock Environments: Managing Catchment and Subsurface Resources (2019)
    Geological Society of London
    Details
    Publication Date: 2019
    Description: 〈p〉Hard rocks, including crystalline igneous, metamorphic and strongly cemented sedimentary and carbonate rocks cover about 50% of the earth's land surface (〈i〉Singhal and Gupta, 2010〈/i〉). Globally, the volume of groundwater contained in hard rock aquifers is not well constrained (〈i〉Comte et al., 2012〈/i〉), but locally they can be important aquifers (〈i〉MacDonald et al., 2012〈/i〉), albeit with low groundwater storage and poor primary porosity and permeability. Groundwater flow in these hard rocks is commonly observed to be associated with water bearing discontinuities, such as fractures, joints and faults (〈i〉Berkowitz, 2002; Mazurek, 2000; Font-Capo et al., 2012〈/i〉) and in the weathered regolith (〈i〉Wright 1992, Chilton and Foster 1995; Deyassa et al., 2014)〈/i〉. Structural elements such as fault zones also strongly govern the behaviour of these systems (〈i〉Forster and Evans, 1991; Lopez and Smith, 1995, Bense et al., 2013〈/i〉). The nature, abundance, orientation and connectivity of these water-bearing features are largely governed by the history and nature of structural deformation of the bedrock and commonly impose strong anisotropic flow and transport parameters on these bedrock aquifers (〈i〉Hsieh et al., 1985; Bour and Davy, 1997; Mortimer et al., 2011〈/i〉). Weathering processes furthermore lead to an alteration of bedrock composition and associated aquifer properties resulting in enhanced fracture connectivity and an overall vertical stratification/zonation of bulk aquifer properties, ranging from highly altered shallow regolith horizons to more competent sparsely fractured bedrock at depth (〈i〉Dewandel et al., 2006; Krasny and Sharp, 2007; Lachassagne et al., 2011〈/i〉).〈/p〉 〈p〉〈b〉...〈/b〉〈/p〉 〈p〉〈i〉This 250-word extract was created in the absence of an abstract.〈/i〉〈/p〉
    Print ISSN: 0375-6440
    Electronic ISSN: 2041-4927
    Topics: Geosciences
    Published by Geological Society of London
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  • 5
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    Regulating the regulator: intramembrane proteolysis of vesicular trafficking proteins and the SERCA regulator phospholamban (2019)
    Springer Nature
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    Publication Date: 2019
    Description: The orphan protease SPPL2c was considered to represent a non‐expressed pseudogene. Two studies in this issue now identify physiological substrates of SPPL2c, and show that it plays a role in vesicle trafficking, Ca2+ transport and spermatid development. Intramembrane proteases reside within the subcellular compartments of cells to carry out a multiplicity of functions. One such family is the signal peptide peptidase (SPP) and signal peptide peptidase‐like (SPPL) family. The SPP/SPPL family comprises several homologs of aspartyl‐intramembrane proteases, and recent studies demonstrate distinct compartmentalization for each and a largely unknown cadre of substrates. Due to their hydrophobic nature, identification of substrates for intramembrane proteases can be an arduous task. In this issue of EMBO Reports, two studies identify physiological substrates of SPPL2c (1, 2). SPPL2c targets a variety of SNARE proteins, thereby playing a significant role in vesicular transport from the ER and in turn influencing the composition of the Golgi. Furthermore, trafficking defects observed in SPPL2c lacking cells lead to morphological changes in the spermatid cells of the testes, the only known site of protein expression. In these cells, phospholamban, a single‐pass transmembrane regulator of the Ca2+ transporter SERCA, was also identified as an SPPL2c substrate that impacts Ca2+ storage. This may explain the SPPL2c effect on germ cell development.
    Print ISSN: 1469-221X
    Electronic ISSN: 1469-3178
    Topics: Biology , Medicine
    Published by Springer Nature on behalf of The European Molecular Biology Organization (EMBO).
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  • 6
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    Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Description: 〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉 〈p〉By activation of 〈i〉Ig〈/i〉 gene rearrangement and receptor editing, Pten controls antibody diversity and the development of self-tolerant B cells. Pten also controls the development of follicular B cellsand their responsiveness towards complex antigen.〈/p〉 〈p〉 〈l type="unord"〉〈li〉〈p〉Pten is required for receptor editing but not for anergy in B cells.〈/p〉〈/li〉 〈li〉〈p〉Increased IgD BCR expression results in mature B cells that are controlled by soluble antigen whileresponsive to antigencomplexes.〈/p〉〈/li〉 〈li〉〈p〉Pten activates IgD BCR expression and selective B cell responsiveness through FoxO1.〈/p〉〈/li〉 〈li〉〈p〉IgD regulates the quality of immune responses by efficiently directing B cells into GC reactions.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
    Print ISSN: 0261-4189
    Electronic ISSN: 1460-2075
    Topics: Biology , Medicine
    Published by Springer Nature on behalf of The European Molecular Biology Organization (EMBO).
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  • 7
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    Spatiotemporal immune zonation of the human kidney (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
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    Publication Date: 2019
    Description: 〈p〉Tissue-resident immune cells are important for organ homeostasis and defense. The epithelium may contribute to these functions directly or by cross-talk with immune cells. We used single-cell RNA sequencing to resolve the spatiotemporal immune topology of the human kidney. We reveal anatomically defined expression patterns of immune genes within the epithelial compartment, with antimicrobial peptide transcripts evident in pelvic epithelium in the mature, but not fetal, kidney. A network of tissue-resident myeloid and lymphoid immune cells was evident in both fetal and mature kidney, with postnatal acquisition of transcriptional programs that promote infection-defense capabilities. Epithelial-immune cross-talk orchestrated localization of antibacterial macrophages and neutrophils to the regions of the kidney most susceptible to infection. Overall, our study provides a global overview of how the immune landscape of the human kidney is zonated to counter the dominant immunological challenge.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Embryonal precursors of Wilms tumor (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
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    Publication Date: 2019
    Description: 〈p〉Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney tissues that preceded tumor development. These clonal expansions were defined by somatic mutations shared between tumor and normal tissues but absent from blood cells. We also found hypermethylation of the 〈i〉H19〈/i〉 locus, a known driver of Wilms tumor development, in 58% of the expansions. Phylogenetic analyses of bilateral tumors indicated that clonal expansions can evolve before the divergence of left and right kidney primordia. These findings reveal embryonal precursors from which unilateral and multifocal cancers develop.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Factors Associated with Exposure to Trihalomethanes, NHANES 2001–2012 (2019)
    American Chemical Society
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    Publication Date: 2019-12-23
    Print ISSN: 0013-936X
    Electronic ISSN: 1520-5851
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Published by American Chemical Society
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  • 10
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    BioModels—15 years of sharing computational models in life science (2019)
    Oxford University Press
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    Publication Date: 2019-11-08
    Description: Computational modelling has become increasingly common in life science research. To provide a platform to support universal sharing, easy accessibility and model reproducibility, BioModels (https://www.ebi.ac.uk/biomodels/), a repository for mathematical models, was established in 2005. The current BioModels platform allows submission of models encoded in diverse modelling formats, including SBML, CellML, PharmML, COMBINE archive, MATLAB, Mathematica, R, Python or C++. The models submitted to BioModels are curated to verify the computational representation of the biological process and the reproducibility of the simulation results in the reference publication. The curation also involves encoding models in standard formats and annotation with controlled vocabularies following MIRIAM (minimal information required in the annotation of biochemical models) guidelines. BioModels now accepts large-scale submission of auto-generated computational models. With gradual growth in content over 15 years, BioModels currently hosts about 2000 models from the published literature. With about 800 curated models, BioModels has become the world’s largest repository of curated models and emerged as the third most used data resource after PubMed and Google Scholar among the scientists who use modelling in their research. Thus, BioModels benefits modellers by providing access to reliable and semantically enriched curated models in standard formats that are easy to share, reproduce and reuse.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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