Publication Date:
2013-12-13
Description:
Article The long non-coding RNA HOTAIR acts as a scaffold to bring together chromatin silencing complexes in the nucleus. Here, the authors show that HOTAIR also serves as a scaffold between E3 ubiquitin ligases and their substrates and thereby enhances their ubiquitination. Nature Communications doi: 10.1038/ncomms3939 Authors: Je-Hyun Yoon, Kotb Abdelmohsen, Jiyoung Kim, Xiaoling Yang, Jennifer L. Martindale, Kumiko Tominaga-Yamanaka, Elizabeth J. White, Arturo V. Orjalo, John L. Rinn, Stefan G. Kreft, Gerald M. Wilson, Myriam Gorospe
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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