Publication Date:
2018-05-11
Description:
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in 〈i〉PARP1〈/i〉 causing PARP inhibitor resistance, Published online: 10 May 2018; doi:10.1038/s41467-018-03917-2 The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, suggesting alternative resistance mechanisms.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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