ALBERT

Description: Two decades of research indicate causal associations between social relationships and mortality, but important questions remain as to how social relationships affect health, when effects emerge, and how long they last. Drawing on data from four nationally representative longitudinal samples of the US population, we implemented an innovative life course...

Description: Ethanol is the most widely used psychoactive drug and, when used inappropriately, can have deleterious effects. The developing fetus is particularly sensitive to the deleterious effects of ethanol. Fetal alcohol exposure causes Fetal Alcohol Spectrum Disorders (FASD), which have an estimated prevalence reaching 1% in North America (1). FASD are...

Description: The amphibian-killing chytrid fungus Batrachochytrium dendrobatidis ( Bd ) is one of the most generalist pathogens known, capable of infecting hundreds of species globally and causing widespread population declines and extinctions. However, some host species are seemingly unaffected by Bd , tolerating or clearing infections without clinical signs of disease. Variation in host immune responses is commonly evoked for these resistant or tolerant species, yet to date, we have no direct comparison of amphibian species responses to infection at the level of gene expression. In this study, we challenged four Central American frog species that vary in Bd susceptibility, with a sympatric virulent strain of the pathogen. We compared skin and spleen orthologous gene expression using differential expression tests and coexpression gene network analyses. We found that resistant species have reduced skin inflammatory responses and increased expression of genes involved in skin integrity. In contrast, only highly susceptible species exhibited suppression of splenic T-cell genes. We conclude that resistance to chytridiomycosis may be related to a species’ ability to escape the immunosuppressive activity of the fungus. Moreover, our results indicate that within-species differences in splenic proteolytic enzyme gene expression may contribute to intraspecific variation in survival. This first comparison of amphibian functional immunogenomic architecture in response to Bd provides insights into key genetic mechanisms underlying variation in disease outcomes among amphibian species.

Description: Knowledge of the shear stress on a fault during slip is necessary for a physically-based understanding of earthquakes. Borehole temperature measurements inside the fault zone immediately after an earthquake can record the energy dissipated by this stress. In the first Wenchuan Earthquake Fault Zone Scientific Drilling Project hole (Sichuan province, China) we repeatedly measured temperature profiles from 1.3 to 5.3 yr after the 12 May 2008, M w 7.9 Wenchuan earthquake. The previously identified candidate for the principal slip surface had only a small local temperature increase of at most 0.02 °C with no obvious decay. The small amplitude of the temperature increase provides an upper bound for the frictional heat–generated coseismic slip, but is unlikely to be a frictionally generated signal. Two larger temperature anomalies are located above and within the fault zone. However, neither anomaly evolves as expected from a frictional transient. We conclude that the frictional heat from the Wenchuan earthquake remains elusive and the total heat generated at this location is much less than 29 MJ/m 2 . Low friction during slip is consistent with the temperature data.

Description: Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component have started to emerge from genome-wide association studies (GWAS), although the majority remain unknown. Unexpectedly, we observed an intergenic locus on 7p15.2 that was genome-wide significantly associated with both endometriosis and fat distribution (waist-to-hip ratio adjusted for BMI; WHRadjBMI) in an independent meta-GWAS of European ancestry individuals. This led us to investigate the potential overlap in genetic variants underlying the aetiology of endometriosis, WHRadjBMI and BMI using GWAS data. Our analyses demonstrated significant enrichment of common variants between fat distribution and endometriosis ( P = 3.7 x 10 –3 ), which was stronger when we restricted the investigation to more severe (Stage B) cases ( P = 4.5 x 10 –4 ). However, no genetic enrichment was observed between endometriosis and BMI ( P = 0.79). In addition to 7p15.2, we identify four more variants with statistically significant evidence of involvement in both endometriosis and WHRadjBMI (in/near KIFAP3 , CAB39L , WNT4 , GRB14 ); two of these, KIFAP3 and CAB39L , are novel associations for both traits. KIFAP3 , WNT4 and 7p15.2 are associated with the WNT signalling pathway; formal pathway analysis confirmed a statistically significant ( P = 6.41 x 10 –4 ) overrepresentation of shared associations in developmental processes/ WNT signalling between the two traits. Our results demonstrate an example of potential biological pleiotropy that was hitherto unknown, and represent an opportunity for functional follow-up of loci and further cross-phenotype comparisons to assess how fat distribution and endometriosis pathogenesis research fields can inform each other.

Description: Journal of the American Chemical Society DOI: 10.1021/ja309863n

Description: 〈span〉〈div〉Summary〈/div〉We analyze 67 new conductive heat flow measurements on the southern flank of the Costa Rica Rift (CRR). Heat flow measurements cover five sites ranging in oceanic crustal age between approximately 1.6 and 5.7 Ma, and are co-located with a high-resolution multi-channel seismic line that extends from slightly north of the first heat flow site (1.6 Ma) to beyond ODP Hole 504B in 6.9 Ma crust. For the five heat flow sites, the mean observed conductive heat flow is ≈ 85 mWm〈sup〉−2〈/sup〉. This value is approximately 30 per cent of the mean lithospheric heat flux expected from a half-space conductive cooling model, indicating that hydrothermal processes account for about 70 per cent of the heat loss. The advective heat loss fraction varies from site to site and is explained by a combination of outcrop to outcrop circulation through exposed basement outcrops and discharge through faults. Super-critical convection in Layer 2A extrusives occurs between 1.6 and 3.5 Ma, and flow through a thinly-sedimented basement high occurs at 4.6 Ma. Advective heat loss diminishes rapidly between ≈ 4.5 and ≈ 5.7 Ma, which contrasts with plate cooling reference models that predict a significant deficit in conductive heat flow up to ages ≈ 65 ± 10 Ma. At ≈ 5.7 Ma the CRR topography is buried under sediment with an average thickness ≈ 150 m, and hydrothermal circulation in the basement becomes sub-critical or perhaps marginally critical. The absence of significant advective heat loss at ≈ 5.7 Ma at the CRR is thus a function of both burial of basement exposure under the sediment load and a reduction in basement permeability that possibly occurs as result of mineral precipitation and original permeability at the time of formation. Permeability is a non-monotonic function of age along the southern flank of the CRR, in general agreement with seismic velocity tomography interpretations that reflect variations in the degree of ridge-axis magma supply and tectonic extension. Hydrothermal circulation in the young oceanic crust at southern flank of CRR is affected by the interplay and complex interconnectedness of variations in permeability, sediment thickness, topographical structure, and tectonic and magmatic activities with age.〈/span〉

Description: 〈span〉〈div〉SUMMARY〈/div〉We analyse 67 new conductive heat-flow measurements on the southern flank of the Costa Rica Rift (CRR). Heat-flow measurements cover five sites ranging in oceanic crustal age between approximately 1.6 and 5.7 Ma, and are co-located with a high-resolution multichannel seismic line that extends from slightly north of the first heat-flow site (1.6 Ma) to beyond ODP Hole 504B in 6.9 Ma crust. For the five heat-flow sites, the mean observed conductive heat flow is ≈85 mW m〈sup〉−2〈/sup〉. This value is approximately 30 per cent of the mean lithospheric heat flux expected from a half-space conductive cooling model, indicating that hydrothermal processes account for about 70 per cent of the heat loss. The advective heat loss fraction varies from site to site and is explained by a combination of outcrop to outcrop circulation through exposed basement outcrops and discharge through faults. Supercritical convection in Layer 2A extrusives occurs between 1.6 and 3.5 Ma, and flow through a thinly sedimented basement high occurs at 4.6 Ma. Advective heat loss diminishes rapidly between ≈4.5 and ≈5.7 Ma, which contrasts with plate cooling reference models that predict a significant deficit in conductive heat flow up to ages ≈65 ± 10 Ma. At ≈5.7 Ma the CRR topography is buried under sediment with an average thickness of ≈150 m, and hydrothermal circulation in the basement becomes subcritical or perhaps marginally critical. The absence of significant advective heat loss at ≈5.7 Ma at the CRR is thus a function of both burial of basement exposure under the sediment load and a reduction in basement permeability that possibly occurs as a result of mineral precipitation and original permeability at the time of formation. Permeability is a non-monotonic function of age along the southern flank of the CRR, in general agreement with seismic velocity tomography interpretations that reflect variations in the degree of ridge-axis magma supply and tectonic extension. Hydrothermal circulation in the young oceanic crust at the southern flank of CRR is affected by the interplay and complex interconnectedness of variations in permeability, sediment thickness, topographical structure, and tectonic and magmatic activities with age.〈/span〉

Description: The Journal of Physical Chemistry B DOI: 10.1021/jp409201v