Publication Date:
2019-11-13
Description:
Introduction: CML accounts for 15-20% of leukemias. Tyrosine kinase inhibitor (TKI) therapy has led to significant improvement in survival rates, approaching the life expectancy of the general public in some settings, with less than three life years lost in a recent Swedish registry study.[1] Understanding cost associated with CML care compared to HEM in the setting of long-term survival on prolonged therapy can aid with resource allocation and clinical decision making. Methods: A retrospective cohort was constructed from OptumLabs® Data Warehouse using claims data between 2000-16. Eligible patients had ≥2 claims for CML and were continuously enrolled for ≥6m prior to diagnosis and ≥1y afterwards. CML patients were compared with HEM and general patients without history of cancer (GEN). As the CML group was the primary group of interest, the HEM and GEN groups were each frequency-matched on an approximate 4:1 ratio to the CML group on the basis of age (10-year increments), sex, year of diagnosis (3-year increments), geographic region (10 US census divisions), and insurance (commercial vs. Medicare Advantage). Follow-up data were available for this analysis through October 31, 2017. The primary outcome was total mean annualized health care costs including medical and outpatient drugs paid by health plan and patient (inflation adjusted to 2017). We used generalized linear models (GLM) to assess the variation in total costs in the three cohorts, using a gamma distribution and a log link. Models were adjusted for frequency-matched factors (sex, age, year of diagnosis, geographic region, insurance). Within the CML cohort, GLM was also used to examine the influence of factors hypothesized to be associated with costs: sex, age at index year, index year, race/ethnicity, insurance, modified Charlson comorbidity index, percent (%) days with TKI prescription, stem cell transplant, and number of inpatient and ambulatory days per year. Results: We identified 1909 enrollees with CML; mean diagnosis age 56y. They were matched with 7,268 HEM patients and 7,636 GEN patients. Mean annualized costs for CML were $82,054, $25,000 more than HEM and approximately $75,000 more than GEN (p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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