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  • 1
    Online Resource
    Online Resource
    Atlas of Human Sperm Ultrastructural Morphology (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Human physiology. ; Urology. ; Biophysics. ; Human Physiology. ; Urology. ; Bioanalysis and Bioimaging.
    Description / Table of Contents: Introduction of human sperm ultrastructural morphology -- Ultrastructural morphology of human sperm head -- Ultrastructural morphology of human sperm neck -- Ultrastructural morphology of human sperm middle piece -- Ultrastructural morphology of human sperm principal piece -- Ultrastructural morphology of human sperm terminal piece -- Ultrastructural morphological measurement of human sperm -- Artefacts of human sperm ultrastructural morphology -- Phenomena related to inadequate preparation of human sperm.
    Abstract: This atlas provides ultrastructural morphological images of human spermatozoa. Sperm morphology plays an essential role in sperm-oocyte interactions and early embryonic development, and human sperm ultrastructural morphology offers a valuable reference tool for assessing certain etiologies of male infertility and reproductive failure. However, the ultrastructural morphology of human sperm has not been systematically evaluated or thoroughly described in the literature. Using 470 original and unpublished images, the book shows various ultrastructural morphological phenotypes; defects of the sperm head, neck, middle piece, principal piece, and terminal piece; as well as artifacts of sperm ultrastructural morphology and phenomena related to inadequate preparation, demonstrating several sperm phenotypes and surface structural appearances for the first time. As such, it helps researchers and practitioners in andrology, reproductive medicine, and reproductive pathology gain a better understanding of human sperm ultrastructural morphology.
    Type of Medium: Online Resource
    Pages: XIII, 276 p. 370 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811553257
    URL: https://doi.org/10.1007/978-981-15-5325-7
    DOI: 10.1007/978-981-15-5325-7
    DDC: 612
    Language: English
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  • 2
    Online Resource
    Online Resource
    Human iPSC-derived Disease Models for Drug Discovery (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Regenerative medicine. ; Stem cells. ; Neuroscience. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology.
    Description / Table of Contents: Part 1 General considerations -- Human iPS for clinical applications and cellular products -- 3D-printed iPS disease models -- Part 2 CNS iPSC and organoids -- iPS-derived neurons and brain organoids from patients (brain) -- iPS-derived RGCs (eye) -- iPS-derived glia (brain) -- iPSC to model blood-brain barrier endothelial cells -- Part 3 iPSC-derived nociceptive neurons -- IPSC-based peripheral nerve modeling -- Part 4 Non-neuronal specialized cell types -- iPSC-based drug screening of differentiated cardiomyocyte subtypes -- iPSC-based cardiac disease modeling: from cell to tissue -- iPSC-derived corneal endothelial cell -- iPSC-derived trabecular meshwork (eye) -- iPSC for in vitro disease modeling of diabetes.
    Abstract: Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
    Type of Medium: Online Resource
    Pages: VIII, 332 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031423499
    Series Statement: Handbook of Experimental Pharmacology, 281
    URL: https://doi.org/10.1007/978-3-031-42349-9
    DOI: 10.1007/978-3-031-42349-9
    DDC: 612.8
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    Interacting distributed approximating functions for real-time quantum dynamics (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 1124-1134 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The distributed approximating function (DAF) approach to quantum real-time dynamics is generalized to include the effects of the potential. The "interacting'' DAF (IDAF) is introduced as the identity for a certain class of functions that can be chosen to approximate as closely as desired any wave packet of interest. Free propagation of the IDAF yields the free propagator for the IDAF class in the coordinate representation, and substitution of this result into the Trotter form for the short-time full propagator, G(x,x'||τ), yields the IDAF class full propagator, G(x,x';{p}||τ), in the coordinate representation. Here {p} denotes the set of parameters that determine the IDAF class. The IDAF class full propagator can be used to develop discretized path integral-based algorithms for real-time quantum dynamics. Use of G(x,x';{p}||τ) in the Feynman path integral formalism leads to a new result with interesting features compared to the standard path integral. Specifically, the IDAF class full propagator incorporates the classical force, and (1) automatically biases the dynamics toward the neighborhood of classical trajectories (but without relying on destructive and constructive interferences in that no recourse is made to stationary phase arguments), (2) automatically concentrates the wave packet in highly classical regions and attenuates the wave packet in highly nonclassical regions. Of the many possible IDAF-based algorithms two are presented as examples. One illustrates a Monte Carlo approach and the other a discretized matrix multiplication approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.465410
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  • 4
    Electronic Resource
    Electronic Resource
    The magneto-optical and optical properties of ultrathin Fe films in the short-wavelength range (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 8011-8014 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The magneto-optical and optical properties of ultrathin Fe films sandwiched between Au layers were studied. A pronounced Kerr rotation peak is observed respectively in the photon energy range of 3.6–3.8 eV when the Fe layer is thinner than 1.5 nm, and in the range of 3.4–3.5 eV for thicker Fe layers. In simple calculations, the Kerr rotation peak is demonstrated to originate from the variation of the off-diagonal element in dielectric tensor of the Fe layers. The relative peak height Δθk, the normalized Kerr rotation θkn, and the effective optical constants at the photon energy of 3.5 eV are found to oscillate as a function of dFe. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362352
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  • 5
    Electronic Resource
    Electronic Resource
    Giant magnetoresistance properties in granular type (Co–Ag)/Ag multilayers (1998)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 83 (1998), S. 900-904 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The giant magnetoresistance of sputtered granular type (Co–Ag)/Ag multilayers with different Co content and sublayer thickness' was studied. With an increasing Ag layer thickness, the magnetoresistance ratio ΔR/R first increases to reach a maximum and then decreases. With an increasing Co content in the magnetic layers, the maximum shifts towards a large Ag layer thickness. These phenomena can be attributed to the antiferromagnetic coupling between the Co clusters in neighboring Co–Ag layers. With an increasing Co–Ag layer thickness, ΔR/R increases monotonically for a small Co content in the magnetic layers, while for a large Co content, a maximum appears at a small magnetic layer thickness. It is suggested that the interplay of spin dependent scattering and the shunting effect in the Co–Ag layers results in the above thickness dependence. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.366775
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  • 6
    Electronic Resource
    Electronic Resource
    Downstream plasma-enhanced diamond film deposition (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 56 (1990), S. 2010-2012 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Diamond films have been deposited on a variety of substrates up to 2 cm below the luminous plasma in a tubular microwave plasma-enhanced chemical vapor deposition system. Depositing downstream of the plasma appears to offer several advantages over immersion of substrates in the plasma, for coating certain oxide substrates, including a reduction in substrate etching and an improvement in film uniformity, adhesion, and transparency. Furthermore, positioning substrates downstream of the plasma and adjusting their temperature with an external heater decouples the plasma and substrate parameters, facilitating studies to determine the effect of various parameters on the chemical vapor deposition diamond process. A disadvantage of downstream deposition is the decrease in the growth rate of diamond films.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.103001
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  • 7
    Electronic Resource
    Electronic Resource
    Oscillations of interlayer coupling and magneto-optics in sputtered Co–Al/Cu multilayers (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 127-129 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have prepared [Co90Al10/Cu]30 multilayers by ion beam sputtering and studied the behavior of interlayer coupling, magnetoresistance, and the magneto-optical Kerr effect. For Co–Al/Cu multilayers, the in-plane saturation field, coercive force HC and magnetoresistance ratio ΔR/R have been observed to oscillate with a period of about 0.9 nm, as a function of Cu spacer layer thickness. Furthermore, polar Kerr rotation θk in visible wavelength range also oscillates with the same period. The magneto-optical activities may be attributed to changes in the optical constants with the magnetic state. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.118097
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  • 8
    Electronic Resource
    Electronic Resource
    Erratum: Variational principles for the time-independent wave-packet-Schrödinger and wave-packet-Lippmann–Schwinger equations [J. Chem. Phys. 100, 3662 (1994)] (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 3414-3414 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.468510
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  • 9
    Electronic Resource
    Electronic Resource
    Variational principles for the time-independent wave-packet-Schrödinger and wave-packet-Lippmann–Schwinger equations (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 100 (1994), S. 3662-3671 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Several variational principles, whose Euler equations are the recently derived time-independent wave-packet-Schrödinger or wave-packet-Lippmann–Schwinger equations, are presented. A particularly attractive wave-packet-Kohn variational principle for either the T- or S-matrix is given which yields inhomogeneous algebraic equations whose "universal inhomogeneity'' does not depend explicitly on the collision energy. The validity of the approach is demonstrated with calculations for two simple one dimensional scattering problems and for the collinear H+H2 reactive scattering problem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.466354
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  • 10
    Electronic Resource
    Electronic Resource
    Further analysis of solutions to the time-independent wave packet equations for quantum dynamics: General initial wave packets (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 1242-1250 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In this paper we reexamine, and analyze solutions to, the recently derived time-independent wave packet-Schrödinger (TIWS) and time-independent wave packet-Lippmann–Schwinger (TIWLS) equations. These equations are so named because they are inhomogeneous, with the inhomogeneity being the initial L2 wave packet from an underlying time-dependent treatment of the dynamics. We explicitly show that a particular solution of the homogeneous Schrödinger equation can be constructed out of two particular solutions of the inhomogeneous TIW equation satisfying causal and anticausal boundary conditions. The structure of this solution of the homogeneous equation is shown to depend sensitively on the nature of the initial wave packet inhomogeneity, but, as we demonstrate, correct scattering information can be obtained even when the initial wave packet is nonzero only in the target region. It thus becomes possible to carry out quantum scattering calculations in which one need not propagate the wave packet from the noninteracting to the interacting region. The method is illustrated by calculations for two 1-D scattering problems, namely the transmission of an electron through a single barrier and through a double barrier. The latter is especially challenging because of the occurrence of long-lived resonances with the electron trapped inside the double barrier. In addition, we show that the method can still make use of absorbing potentials to decrease grid size, and we show how the formalism can be used to treat inelastic and reactive scattering, and radial scattering variables, thereby constituting a general approach to time-independent wave packet quantum scattering.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.468439
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