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  • 1
    Electronic Resource
    Electronic Resource
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Review of marketing science 2.2003, 2, paper3 
    ISSN: 1546-5616
    Source: Berkeley Electronic Press Academic Journals
    Topics: Economics
    Notes: In this paper, we set up a game theoretical model in which an incumbent and an entrant choose their respective R&D strategies to compete with each other. Our paper contributes to three major debates regarding a firm's R&D strategy; the incumbent's and the entrant's choice between a radical R&D project and an incremental one, the incumbent's decision of whether to pre-empt the entrant, and the trade-off between product quality improvement and time-to-market. Our model considers three decisions that both the entrant and the incumbent need to make: (1) the amount of investment in the R&D project, (2) timing of new product introduction, and (3) the magnitude of performance improvement. These three decisions completely define a firm's R&D strategy. As for the product performance improvement, the entrant has to decide whether to introduce an incrementally improved product or a drastically improved one. With the incrementally improved product, the entrant can enter the market earlier at a low R&D cost, but it will lag behind the incumbent in product performance. On the other hand, with the drastically improved product, the entrant may be able to leapfrog the incumbent in product performance, but the downside is that the entry needs to be delayed or more investment in the R&D project is needed. The entrant's strategy is further affected by the incumbent's potential reaction. The incumbent, anticipating the entrant's entry, can react by either improving its product incrementally or drastically. The incumbent can even pre-empt the entrant's entry by introducing its new product before the entry occurs. We find that, when trading off time-to-market against quality improvement, both the incumbent and the entrant should emphasize quality improvement over time-to-market. Specifically, the entrant should enter the market with a drastically improved new product, even if it means that the entry has to be delayed. The incumbent, anticipating the entrant's move, should react by introducing a drastically improved new product as well. Therefore, in the debate about the relative importance of time-to-market and quality improvement, we side with the school of thoughts that emphasizes the latter. Furthermore, we find that there is no need for the incumbent to pre-empt the entrant's move, i.e., the incumbent should introduce its new product only after entry even if it is certain about entry at the very beginning. This is different from Gilbert and Newbery's (1982) finding that the incumbent should pre-empt the entrant, and it is also different from Kamien and Schwartz (1972) who show that the incumbent will delay its R&D indefinitely in the face of competition. As for the incumbent's and the entrant's choices of either a radical innovation or an incremental one, our finding is consistent with the conventional wisdom that the entrant should introduce a radically innovative product (Day and Shoemaker 2000). However, our findings on the incumbent's choice of R&D project differ from any existing studies that advocate a cautious approach (e.g., Reinganum 1983). In recent years, many leading companies in various industries have come to the same conclusion and began to invest in more drastic R&D projects (see Chandy and Tellis 2000), as advocated by our findings. Our findings are also different from other studies in that we have produced clear and easy-to-understand findings. In contrast, many existing studies (e.g., Ali, Kalwani and Kovenock 1993; Cohen, Eliashberg, and Ho 1996; Bayus, Jain and Rao 1997) provide more nuanced but also ambiguous results that depend on market conditions that are difficult to empirically validate. The intuition for our major finding that both the incumbent and the entrant should engage in radical R&D projects is relatively straightforward. Consider the entrant first. If the entrant enters the market with an incrementally improved product, such is not forceful enough to challenge the incumbent's dominant position; hence, it is a dominated strategy by a drastic R&D project. And, knowing that the entrant's product will be always drastically improved, the incumbent should react likewise to protect its leadership position. The optimal entry time for the entrant and the reaction time for the incumbent are determined according to the trade-off of R&D costs and firm profits, and in equilibrium, the incumbent will not pre-empt entry to minimize its R&D costs. We also study the scenario where the incumbent does not anticipate the entry. In this case, in order to take advantage of the incumbent's delayed reaction, the entrant should accelerate its entry, but should not change its product strategy, that is, is should still introduce a drastically improved new product. Although being caught off guard by the entrant's surprise entry, the incumbent should not react hastily. Rather, it should proceed with the same pace in its R&D process as in the previous case and introduce a drastically improved new product.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 373-374 (Mar. 2008), p. 617-620 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Nd, Ce and Pr in ER-magnets are very active and easy react with oxygen and otheroxidizing substance [1]. So this paper deals with the formation of some organic films on theNd8Fe80B6Co6 magnetic powders. Then the belt of the alloy was made in a melt-spun furnace andthen heat-treated at certain temperature. After that the magnetic powders were prepared by specialcrashing techniques. Epoxy resin and titanate were chosen as coat materials. The test showed thatthe epoxy-titanate coating material has the lowest weight increase in the exposure of oxidationatmosphere. Effects of the coat materials on the properties of bonded alloy were also investigated.The magnetic properties of the alloy with epoxy-titanate coating material were similar to onewithout coat
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 373-374 (Mar. 2008), p. 637-640 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: MMCs wire can be produced by infiltration of molten metal into carbon fiber bundles. Toprotect the fibers from damage, the desized fibers must be pretreated before fabrication into wire.This paper deals with the formation of SiO2 coating on the carbon fibers using plasma chemicalmethod and compares the coating produced by plasma method with the one by sol-gel method. TheSiO2 coating produced by the sol-gel method on the carbon fibers is very rough. It is alsodiscovered that the quality of the SiO2 coating is controlled by the power of plasma equipment andthe flow rate of plasma gases. As the power of the plasma equipment and the flow rate of plasmagases increased, the coating surface became smoother
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 546-549 (May 2007), p. 437-438 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The infiltration pressure field of fiber reinforced AZ91D was studied in this paper. Thecarbon fiber T300 was selected and covered with rough TiO2 coat by means of plasma techniques.These carbon fibers were combined together and a kind of continuous pre-former with manymicro-passes was constructed. When this pre-former went though a infiltration cabin filled withmolten magnesium alloys, the melt infiltrated into pre-former through those micro-passes underinfiltration pressure. A physical model and related mathematic model were built to relate this process.The relationship among pressure (p), infiltration flow rate change (e) and the location of infiltrationflow (r) was molded
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Marketing letters 11 (2000), S. 221-233 
    ISSN: 1573-059X
    Keywords: Advertising spending ; perceived quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract In this paper we examine the relationship between advertising spending and perceived product quality. The questions we ask are: Does a product's advertising spending influence consumers' perceptions of its quality? If so, does the effect remain even after accounting for objective quality, price and market share? Does knowledge about objective quality, from Consumer Reports or usage experience, attenuate the effect of advertising spending on perceived quality? Do nondurable goods differ from durable goods in these effects? In ten product categories, five nondurable and five durable, comprising a total of 162 brands, we find that advertising expenditure and perceived quality are generally positively correlated even after accounting for objective quality, price, and market share—for both nondurable goods and durable goods. Objective quality, however, is significantly correlated with perceived quality only for durable goods, after advertising spending, price and market share are accounted for. Finally, previous purchase experience, but not Consumer Reports readership, reduces the effect of advertising spending on perceived quality.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2019-06-03
    Description: In China, pottery containers first appeared about 20000 cal. BP, and became diverse in form during the Early Neolithic (9000–7000 cal. BP), signaling the emergence of functionally specialized vessels. China is also well-known for its early development of alcohol production. However, few studies have focused on the connections between the two technologies. Based on the analysis of residues (starch, phytolith, and fungus) adhering to pottery from two Early Neolithic sites in north China, here we demonstrate that three material changes occurring in the Early Neolithic signal innovation of specialized alcoholic making known in north China: (i) the spread of cereal domestication (millet and rice), (ii) the emergence of dedicated pottery types, particularly globular jars as liquid storage vessels, and (iii) the development of cereal-based alcohol production with at least two fermentation methods: the use of cereal malts and the use of moldy grain and herbs (quandcaoqu) as starters. The latter method was arguably a unique invention initiated in China, and our findings account for the earliest known examples of this technique. The major ingredients include broomcorn millet, Triticeae grasses, Job’s tears, rice, beans, snake gourd root, ginger, possible yam and lily, and other plants, some probably with medicinal properties (e.g., ginger). Alcoholic beverages made with these methods were namedli,jiu, andchangin ancient texts, first recorded in the Shang oracle-bone inscriptions (ca. 3200 cal. BP); our findings have revealed a much deeper history of these diverse fermentation technologies in China.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 7
    Publication Date: 2019-01-11
    Description: Immune checkpoint therapy (ICT) has transformed cancer treatment in recent years; however, treatment response is not uniform across tumor types. The tumor immune microenvironment plays a critical role in determining response to ICT; therefore, understanding the differential immune infiltration between ICT-sensitive and ICT-resistant tumor types will help to develop effective treatment strategies. We performed a comprehensive analysis of the immune tumor microenvironment of an ICT-sensitive tumor (melanoma, n = 44) and an ICT-resistant tumor (pancreatic cancer, n = 67). We found that a pancreatic tumor has minimal to moderate infiltration of CD3, CD4, and CD8 T cells; however, the immune infiltrates are predominantly present in the stromal area of the tumor and are excluded from tumoral area compared with melanoma, where the immune infiltrates are primarily present in the tumoral area. Metastatic pancreatic ductal adenocarcinomas (PDACs) had a lower infiltration of total T cells compared with resectable primary PDACs, suggesting that metastatic PDACs have poor immunogenicity. Further, a significantly higher number of CD68+ macrophages and VISTA+ cells (also known as V-domain immunoglobulin suppressor of T cell activation) were found in the pancreatic stromal area compared with melanoma. We identified VISTA as a potent inhibitory checkpoint that is predominantly expressed on CD68+ macrophages on PDACs. These data suggest that VISTA may be a relevant immunotherapy target for effective treatment of patients with pancreatic cancer.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
  • 9
    Publication Date: 2015-08-13
    Description: Energy & Fuels DOI: 10.1021/acs.energyfuels.5b01233
    Print ISSN: 0887-0624
    Electronic ISSN: 1520-5029
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
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  • 10
    Publication Date: 2016-07-13
    Description: Long non-coding RNAs (lncRNAs) are being discovered as a novel family of regulators of gene expression at the epigenetic level. Emerging lines of evidence demonstrate that interplays between lncRNAs and DNA me...
    Electronic ISSN: 2045-3701
    Topics: Biology
    Published by BioMed Central
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