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  • 1
    Electronic Resource
    Electronic Resource
    Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor (2004)
    [s.l.] : Nature Publishing Group
    Nature medicine 10 (2004), S. 40-47 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Current antiestrogen therapy for breast cancer is limited by the mixed estrogenic and antiestrogenic activity of selective estrogen receptor modulators. Here we show that the function of zinc fingers in the estrogen receptor DNA-binding domain (DBD) is susceptible to chemical inhibition by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm969
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  • 2
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    Delayed baroclinic response of the Antarctic circumpolar current to surface wind stress (2009)
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © Science in China Press, 2008. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Science in China Series D: Earth Sciences 51 (2008): 1036-1043, doi:10.1007/s11430-008-0074-8.
    Description: Antarctic Circumpolar Current (ACC) responds to the surface windstress via two processes, i.e., instant barotropic process and delayed baroclinic process. This study focuses on the baroclinic instability mechanism in ACC. That is, the strengthening of surface zonal windstress causes the enhanced tilting of the isopycnal surface, which leads to the intense baroclinic instability. Simultaneously, the mesoscale eddies resulting from the baroclinic instability facilitate the transformation of mean potential energy to eddy energy, which causes the remarkable decrease of the ACC volume transport with the 2-year lag time. This delayed negative correlation between the ACC transport and the zonal windstress may account for the steadiness of the ACC transport in these two decades.
    Description: Supported by NSCF Outstanding Young Scientist Award (Grant No. 40625017) and the National Basic Research Program of China (Grant No. 2006CB403604). The research was also supported by W. Alan Clark Chair from Woods Hole Oceanographic Institution for RXH and NOAA GLERL contribution No. 1462 for JW
    Keywords: Antarctic Circumpolar Current (ACC) ; Zonal windstress ; Baroclinic instability ; Mesoscale eddy
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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  • 3
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    Decadal changes of wind stress over the Southern Ocean associated with Antarctic ozone depletion (2010)
    American Meteorological Society
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © American Meteorological Society, 2007. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 20 (2007): 3395-3410, doi:10.1175/JCLI4195.1
    Description: Using 40-yr ECMWF Re-Analysis (ERA-40) data and in situ observations, the positive trend of Southern Ocean surface wind stress during two recent decades is detected, and its close linkage with spring Antarctic ozone depletion is established. The spring Antarctic ozone depletion affects the Southern Hemisphere lower-stratospheric circulation in late spring/early summer. The positive feedback involves the strengthening and cooling of the polar vortex, the enhancement of meridional temperature gradients and the meridional and vertical potential vorticity gradients, the acceleration of the circumpolar westerlies, and the reduction of the upward wave flux. This feedback loop, together with the ozone-related photochemical interaction, leads to the upward tendency of lower-stratospheric zonal wind in austral summer. In addition, the stratosphere–troposphere coupling, facilitated by ozone-related dynamics and the Southern Annular Mode, cooperates to relay the zonal wind anomalies to the upper troposphere. The wave–mean flow interaction and the meridional circulation work together in the form of the Southern Annular Mode, which transfers anomalous wind signals downward to the surface, triggering a striking strengthening of surface wind stress over the Southern Ocean.
    Description: This study was supported by MOST of China (Grant 2006CB403604) and Chinese Academy of Sciences (Grant KZSW2-YW-214) (for YXY and DXW) and W. Alan Clark Chair from Woods Hole Oceanographic Institution (for RXH).
    Keywords: Wind stress ; Decadal variability ; Ozone ; Southern Ocean ; Stratospheric circulation
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 4
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    The Atlantic Water boundary current in the Chukchi Borderland and Southern Canada Basin (2020)
    American Geophysical Union
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 125(8), (2020): e2020JC016197, doi:10.1029/2020JC016197.
    Description: Synoptic shipboard measurements, together with historical hydrographic data and satellite data, are used to elucidate the detailed structure of the Atlantic Water (AW) boundary current system in the southern Canada Basin and its connection to the upstream source of AW in the Chukchi Borderland. Nine high‐resolution occupations of a transect extending from the Beaufort shelf to the deep basin near 152°W, taken between 2003 and 2018, reveal that there are two branches of the AW boundary current that flow beneath and counter to the Beaufort Gyre. Each branch corresponds to a warm temperature core and transports comparable amounts of Fram Strait Branch Water between roughly 200–700 m depth, although they are characterized by a different temperature/salinity (T/S) structure. The mean volume flux of the combined branches is 0.87 ± 0.13 Sv. Using the historical hydrographic data, the two branches are tracked upstream by their temperature cores and T/S signatures. This sheds new light on how the AW negotiates the Chukchi Borderland and why two branches emerge from this region. Lastly, the propagation of warm temperature anomalies through the region is quantified and shown to be consistent with the deduced circulation scheme.
    Description: This work was funded by the following sources: National Science Foundation Grants PLR‐1504333, OPP‐1733564, and OPP‐1504394; National Oceanic and Atmospheric Administration Grant NA14OAR4320158; and National Aeronautics and Space Administration Grant NNX10AF42G.
    Description: 2021-01-27
    Repository Name: Woods Hole Open Access Server
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  • 5
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    Connection between the decadal variability in the Southern Ocean circulation and the Southern Annular Mode (2010)
    American Geophysical Union
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2007. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 34 (2007): L16604, doi:10.1029/2007GL030526.
    Description: Previous studies demonstrated the remarkable upward trend of the Southern Annular Mode (SAM) and Southern Ocean wind stress in association with anthropogenic forcing. An oceanic reanalysis data set is used to investigate the response of the circulation in the Southern Ocean to the decadal variability of SAM. Our results indicate the strengthening and the poleward shift of the northward Ekman velocity as well as the Ekman pumping rate, which led to a corresponding strengthening trend in the Deacon Cell. This strengthening, in turn, intensified the meridional density gradient and the tilting of the isopycnal surfaces. On the interannual time scale, the Antarctic Circumpolar Currents (ACC) transport exhibits a positive correlation with SAM index as seen separately in observations. However, there is no significant trend in the total transport of ACC. Possible reasons are discussed.
    Description: This work was supported by the Chinese Academy of Sciences (Grant KZSW2-YW-214), the Natural Science Foundation of China (Grant 40640420557) and National Basic Research Program of China (Grant 2006CB403604) for X-Y. Yang and D. Wang, and by W. Alan Clark Chair from Woods Hole Oceanographic Institution for R.X. Huang.
    Keywords: Decadal variability ; Southern Ocean circulation ; Southern Annular Mode
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 6
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    Time dependent flow of Atlantic water on the continental slope of the Beaufort Sea based on moorings (2021)
    American Geophysical Union
    Details
    Publication Date: 2022-05-27
    Description: Author Posting. © American Geophysical Union, 2021. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 126(6), (2021): e2020JC016996, https://doi.org/10.1029/2020JC016996.
    Description: The flow and transformation of warm, salty Atlantic-origin water (AW) in the Arctic Ocean plays an important role in the global overturning circulation that helps regulate Earth's climate. The heat that it transports also impacts ice melt in different parts of the Arctic. This study uses data from a mooring array deployed across the shelf/slope of the Alaskan Beaufort Sea from 2002–2004 to investigate the flow of AW. A short-lived “rebound jet” of AW on the upper continental slope regularly follows wind-driven upwelling events. A total of 57 such events, lasting on average 3 days each, occurred over the 2 year period. As the easterly wind subsides, the rebound jet quickly spins up while the isopycnals continue to slump from their upwelled state. The strength of the jet is related to the cross-slope isopycnal displacement, which in turn is dependent on the magnitude of the wind, in line with previous modeling. Seaward of the rebound jet, the offshore-most mooring of the array measured the onshore branch of the AW boundary flowing eastward in the Canada Basin. However, the signature of the boundary current was only evident in the second year of the mooring timeseries. We suspect that this is due to the varying influence of the Beaufort Gyre in the two years, associated with a change in pattern of the wind stress curl that helps drive the gyre.
    Description: Support for this research was provided by the National Science Foundation, under grants PLR-1504333 and OPP-1733564; the National Oceanic and Atmospheric Administration, under grant NA14OAR4320158; and the National Key R&D Program of China (2019YFA0606702).
    Description: 2021-11-26
    Repository Name: Woods Hole Open Access Server
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  • 7
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    Experiment and Simulation Study on the Special Phase Behavior of Huachang Near-Critical Condensate Gas Reservoir Fluid (2016)
    Hindawi
    Details
    Publication Date: 2016-04-08
    Description: Due to the special phase behavior of near-critical fluid, the development approaches of near-critical condensate gas and near-critical volatile oil reservoirs differ from conventional oil and gas reservoirs. In the near-critical region, slightly reduced pressure may result in considerable change in gas and liquid composition since a large amount of gas or retrograde condensate liquid is generated. It is of significance to gain insight into the composition variation of near-critical reservoir during the depletion development. In our study, we performed a series of PVT experiments on a real near-critical gas condensate reservoir fluid. In addition to the experimental studies, a commercial simulator combined with the PREOS model was utilized to study retrograde condensate characteristics and reevaporation mechanism of condensate oil with CO2 injection based on vapor-liquid phase equilibrium thermodynamic theory. The research shows that when reservoir pressure drops below a certain pressure, the variation of retrograde condensate liquid saturation of the residual reservoir fluid exhibits the phase behavior of volatile oil.
    Print ISSN: 2090-9063
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 8
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    Enhanced Neuroprotection of Minimally Invasive Surgery Joint Local Cooling Lavage against ICH-induced Inflammation Injury and Apoptosis in Rats (2015)
    Springer
    Details
    Publication Date: 2015-07-31
    Print ISSN: 0272-4340
    Electronic ISSN: 1573-6830
    Topics: Biology
    Published by Springer
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  • 9
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    Adoptive Regulatory T-cell Therapy Attenuates Perihematomal Inflammation in a Mouse Model of Experimental Intracerebral Hemorrhage (2016)
    Springer
    Details
    Publication Date: 2016-09-27
    Print ISSN: 0272-4340
    Electronic ISSN: 1573-6830
    Topics: Biology
    Published by Springer
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  • 10
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    Dynamical Link between the Barents–Kara Sea Ice and the Arctic Oscillation (2016)
    American Meteorological Society
    Details
    Publication Date: 2016-06-28
    Description: The recent accelerated Arctic sea ice decline has been proposed as a possible forcing factor for midlatitude circulation changes, which can be projected onto the Arctic Oscillation (AO) and/or North Atlantic Oscillation (NAO) mode. However, the timing and physical mechanisms linking AO responses to the Arctic sea ice forcing are not entirely understood. In this study, the authors suggest a connection between November sea ice extent in the Barents and Kara Seas and the following winter’s atmospheric circulation in terms of the fast sea ice retreat and the subsequent modification of local air–sea heat fluxes. In particular, the dynamical processes that link November sea ice in the Barents and Kara Seas with the development of AO anomalies in February is explored. In response to the lower-tropospheric warming associated with the initial thermal effect of the sea ice loss, the large-scale atmospheric circulation goes through a series of dynamical adjustment processes: The decelerated zonal-mean zonal wind anomalies propagate gradually from the subarctic to midlatitudes in about one month. The equivalent barotropic AO dipole pattern develops in January because of wave–mean flow interaction and firmly establishes itself in February following the weakening and warming of the stratospheric polar vortex. This connection between sea ice loss and the AO mode is robust on time scales ranging from interannual to decadal. Therefore, the recent winter AO weakening and the corresponding midlatitude climate change may be partly associated with the early winter sea ice loss in the Barents and Kara Seas.
    Print ISSN: 0894-8755
    Electronic ISSN: 1520-0442
    Topics: Geography , Geosciences , Physics
    Published by American Meteorological Society
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