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  • 1
    Publication Date: 2018-01-18
    Description: It is recently demonstrated that amorphous Ge anode shows higher reversible Na-ion storage capacity (590 mA h g –1 ) than crystallized Ge anode (369 mA h g –1 ). Here, amorphous GeO x anode is prepared by a simple wet-chemistry reduction route at room temperature. The obtained amorphous GeO x shows a porous hierarchical architecture, accompanied with a Brunauer–Emmett–Teller surface area of 159 m 2 g –1 and an average pore diameter of 14 nm. This unique structure enables the GeO x anode to enhance the Na-ion/electron diffusion rate, and buffer the volume change. As anode for Na-ion battery, high reversible capacity over 400 mA h g –1 , fine rate capability with a capacity of 200 mA h g –1 maintained at 3.0 A g –1 and long-term cycling stability with 270 mA h g –1 even over 1000 cycles at 1.0 A g –1 are obtained.
    Keywords: inorganic chemistry, materials science
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 2
    Publication Date: 2019
    Description: Abstract The 2018 tropical cyclone (TC) season in the North Pacific was very active, with 39 tropical storms including 8 typhoons/hurricanes. This activity was successfully predicted up to 5 months in advance by the Geophysical Fluid Dynamics Laboratory Forecast‐oriented Low Ocean Resolution (FLOR) global coupled model. In this work, a suite of idealized experiments with three dynamical global models (FLOR, NICAM and MRI‐AGCM) was used to show that the active 2018 TC season was primarily caused by warming in the subtropical Pacific, and secondarily by warming in the tropical Pacific. Furthermore, the potential effect of anthropogenic forcing on the active 2018 TC season was investigated using two of the global models (FLOR and MRI‐AGCM). The models projected opposite signs for the changes in TC frequency in the North Pacific by an increase in anthropogenic forcing, thereby highlighting the substantial uncertainty and model dependence in the possible impact of anthropogenic forcing on Pacific TC activity.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
    Publication Date: 2015-07-07
    Description: Human RPE65 mutations cause a spectrum of blinding retinal dystrophies from severe early-onset disease to milder manifestations. The RPE65 P25L missense mutation, though having 〈10% of wild-type (WT) activity, causes relatively mild retinal degeneration. To better understand these mild forms of RPE65 -related retinal degeneration, and their effect on cone photoreceptor survival, we generated an Rpe65 /P25L knock-in (KI/KI) mouse model. We found that, when subject to the low-light regime (~100 lux) of regular mouse housing, homozygous Rpe65 /P25L KI/KI mice are morphologically and functionally very similar to WT siblings. While mutant protein expression is decreased by over 80%, KI/KI mice retinae retain comparable 11- cis -retinal levels with WT. Consistently, the scotopic and photopic electroretinographic (ERG) responses to single-flash stimuli also show no difference between KI/KI and WT mice. However, the recovery of a-wave response following moderate visual pigment bleach is delayed in KI/KI mice. Importantly, KI/KI mice show significantly increased resistance to high-intensity (20 000 lux for 30 min) light-induced retinal damage (LIRD) as compared with WT, indicating impaired rhodopsin regeneration in KI/KI. Taken together, the Rpe65 /P25L mutant produces sufficient chromophore under normal conditions to keep opsins replete and thus manifests a minimal phenotype. Only when exposed to intensive light is this hypomorphic mutation manifested physiologically, as its reduced expression and catalytic activity protects against the successive cycles of opsin regeneration underlying LIRD. These data also help define minimal requirements of chromophore for photoreceptor survival in vivo and may be useful in assessing a beneficial therapeutic dose for RPE65 gene therapy in humans.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 4
    Publication Date: 2015-11-27
    Description: Auction mechanism has been widely applied to cognitive radio networks to motivate spectrum redistribution among unlicensed users and spectrum holders, in which unlicensed users with cognitive radio capability can access the licensed spectrum by compensating spectrum holders with monetary payment. However, most of prior studies on auction are mainly restricted to channel allocation with the assumption of fixed transmitting power and/or neglecting spectrum holders’ interference restrictions. Few of them jointly considers the channel and power allocation. Additionally, power allocation may cause non-identical interference relationships among unlicensed users due to the variable interference ranges. In this paper, we propose two truthful double auction schemes under single-channel demand and multi-channel demand, respectively. We theoretically prove that the two auction schemes both achieve the desired economic properties. Results from numerical evaluation demonstrate our analysis.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
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  • 5
    Publication Date: 2011-02-17
    Description: As the most populated region of the world, Asia is a major source of aerosols with potential large impact over vast downstream areas. Papers published in this special section describe the variety of aerosols observed in China and their effects and interactions with the regional climate as part of the East Asian Study of Tropospheric Aerosols and their Impact on Regional Climate (EAST-AIRC). The majority of the papers are based on analyses of observations made under three field projects, namely, the Atmospheric Radiation Measurements (ARM) Mobile Facility mission in China (AMF-China), the East Asian Study of Tropospheric Aerosols: An International Regional Experiment (EAST-AIRE), and the Atmospheric Aerosols of China and their Climate Effects (AACCE). The former two are U.S.-China collaborative projects, and the latter is a part of the China's National Basic Research program (or often referred to as “973 project”). Routine meteorological data of China are also employed in some studies. The wealth of general and specialized measurements lead to extensive and close-up investigations of the optical, physical, and chemical properties of anthropogenic, natural, and mixed aerosols; their sources, formation, and transport mechanisms; horizontal, vertical, and temporal variations; direct and indirect effects; and interactions with the East Asian monsoon system. Particular efforts are made to advance our understanding of the mixing and interaction between dust and anthropogenic pollutants during transport. Several modeling studies were carried out to simulate aerosol impact on radiation budget, temperature, precipitation, wind and atmospheric circulation, fog, etc. In addition, impacts of the Asian monsoon system on aerosol loading are also simulated.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
    Publication Date: 2011-07-01
    Description: Analytical Chemistry DOI: 10.1021/ac2009993
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
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  • 7
    Publication Date: 2011-05-11
    Description: Powdery mildew resistance gene Pm21, located on the chromosome 6V short arm of Haynaldia villosa and transferred to wheat as a 6VS·6AL translocation (T6VS·6AL), confers durable and broad-spectrum resistance to wheat powdery mildew. Pm21 has become a key gene resource for powdery mildew resistance breeding all over the world. In China, 12 wheat varieties containing Pm21 have been planted on more than 3.4 million hectares since 2002. Pm21 has been intractable to molecular genetic mapping because the 6VS does not pair and recombine with the 6AS. Moreover, all known accessions of H. villosa are immune to powdery mildew fungus. Pm21 is still defined by cytogenetics as a locus. In the present study, a putative serine and threonine protein kinase gene Stpk-V was cloned and characterized with an integrative strategy of molecular and cytogenetic techniques. Stpk-V is located on the Pm21 locus. The results of a single cell transient expression assay showed that Stpk-V could decrease the haustorium index dramatically. After the Stpk-V was transformed into a susceptible wheat variety Yangmai158, the characterized transgenic plants showed high and broad-spectrum powdery mildew resistance similar to T6VS·6AL. Silencing of the Stpk-V by virus-induced gene silencing in both T6VS·6AL and H. villosa resulted in their increased susceptibility. Stpk-V could be induced by Bgt and exogenous H2O2, but it also mediated the increase of endogenous H2O2, leading to cell death and plant resistance when the plant was attacked by Bgt.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
    Publication Date: 2013-10-10
    Description: Author(s): J.-Y. Zhang, Y. Qian, Z.-C. Yan, and U. Schwingenschlögl The dispersion coefficients C 6 , C 8 , and C 10 for long-range interactions of He( n   1,3 S ) and He( n   1,3 P ), 2≤ n ≤10, with the ground-state noble-gas atoms Ne, Ar, Kr, and Xe are calculated by summing over the reduced matrix elements of multipole transition operators. The large- n expansions for the sums ove... [Phys. Rev. A 88, 044701] Published Wed Oct 09, 2013
    Keywords: Atomic and molecular collisions and interactions
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
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  • 9
    Publication Date: 2014-03-13
    Description: DNA methylation is an important defense and regulatory mechanism. In mammals, most DNA methylation occurs at CpG sites, and asymmetric non-CpG methylation has only been detected at appreciable levels in a few cell types. We are the first to systematically study the strand-specific distribution of non-CpG methylation. With the divide-and-compare strategy, we show that CHG and CHH methylation are not intrinsically different in human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We also find that non-CpG methylation is skewed between the two strands in introns, especially at intron boundaries and in highly expressed genes. Controlling for the proximal sequences of non-CpG sites, we show that the skew of non-CpG methylation in introns is mainly guided by sequence skew. By studying subgroups of transposable elements, we also found that non-CpG methylation is distributed in a strand-specific manner in both short interspersed nuclear elements (SINE) and long interspersed nuclear elements (LINE), but not in long terminal repeats (LTR). Finally, we show that on the antisense strand of Alus, a non-CpG site just downstream of the A-box is highly methylated. Together, the divide-and-compare strategy leads us to identify regions with strand-specific distributions of non-CpG methylation in humans.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 10
    Publication Date: 2014-09-25
    Description: Motivation: Mass spectrometry (MS)-based high-throughput quantitative proteomics shows great potential in large-scale clinical biomarker studies, identifying and quantifying thousands of proteins in biological samples. However, there are unique challenges in analyzing the quantitative proteomics data. One issue is that the quantification of a given peptide is often missing in a subset of the experiments, especially for less abundant peptides. Another issue is that different MS experiments of the same study have significantly varying numbers of peptides quantified, which can result in more missing peptide abundances in an experiment that has a smaller total number of quantified peptides. To detect as many biomarker proteins as possible, it is necessary to develop bioinformatics methods that appropriately handle these challenges. Results: We propose a Significance Analysis for Large-scale Proteomics Studies (SALPS) that handles missing peptide intensity values caused by the two mechanisms mentioned above. Our model has a robust performance in both simulated data and proteomics data from a large clinical study. Because varying patients’ sample qualities and deviating instrument performances are not avoidable for clinical studies performed over the course of several years, we believe that our approach will be useful to analyze large-scale clinical proteomics data. Availability and Implementation: R codes for SALPS are available at http://www.stanford.edu/%7eclairesr/software.html . Contact: wenzhong.xiao@mgh.harvard.edu Supplementary information: Supplementary materials are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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