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  • 1
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    Magnetic anisotropy of Kondo semiconductor CeT_{2}Al_{10} (T= Ru,Os) in the ordered state (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-05-18
    Description: Author(s): H. Tanida, Y. Nonaka, D. Tanaka, M. Sera, Y. Kawamura, Y. Uwatoko, T. Nishioka, and M. Matsumura We studied the applied magnetic field direction ( θ ) dependence of the magnetic and transport properties of Ce T 2 Al 10 ( T = Ru, Os) in the a b , b c , and c a planes focusing on the magnetic anisotropy in the ordered state. The magnetization of NdOs 2 Al 10 was also studied as a reference of Ce T 2 Al 10 . The resul... [Phys. Rev. B 85, 205208] Published Thu May 17, 2012
    Keywords: Semiconductors I: bulk
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice (2017)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2017-06-22
    Description: Serotonin is a critical modulator of cortical function, and its metabolism is defective in autism spectrum disorder (ASD) brain. How serotonin metabolism regulates cortical physiology and contributes to the pathological and behavioral symptoms of ASD remains unknown. We show that normal serotonin levels are essential for the maintenance of neocortical excitation/inhibition balance, correct sensory stimulus tuning, and social behavior. Conversely, low serotonin levels in 15q dup mice (a model for ASD with the human 15q11-13 duplication) result in impairment of the same phenotypes. Restoration of normal serotonin levels in 15q dup mice revealed the reversibility of a subset of ASD-related symptoms in the adult. These findings suggest that serotonin may have therapeutic potential for discrete ASD symptoms.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Ammonia excitation imaging of shocked gas towards the W28 gamma-ray source HESS J1801-233 (2016)
    Oxford University Press
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    Publication Date: 2016-08-04
    Description: We present 12 mm Mopra observations of the dense (〉10 3  cm –3 ) molecular gas towards the north-east of the W28 supernova remnant (SNR). This cloud is spatially well matched to the TeV gamma-ray source HESS J1801–233 and is known to be an SNR-molecular cloud interaction region. Shock-disruption is evident from broad NH 3 (1,1) spectral linewidths in regions towards the W28 SNR, while strong detections of spatially extended NH 3 (3,3), NH 3 (4,4) and NH 3 (6,6) inversion emission towards the cloud strengthen the case for the existence of high temperatures within the cloud. Velocity dispersion measurements and NH 3 ( n , n )/(1,1) ratio maps, where n = 2, 3, 4 and 6, indicate that the source of disruption is from the side of the cloud nearest to the W28 SNR, suggesting that it is the source of cloud-disruption. Towards part of the cloud, the ratio of ortho to para-NH 3 is observed to exceed 2, suggesting gas-phase NH 3 enrichment due to NH 3 liberation from dust-grain mantles. The measured NH 3 abundance with respect to H 2 is ~(1.2 ± 0.5) x 10 –9 , which is not high, as might be expected for a hot, dense molecular cloud enriched by sublimated grain-surface molecules. The results are suggestive of NH 3 sublimation and destruction in this molecular cloud, which is likely to be interacting with the W28 SNR shock.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 4
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    The dust properties and physical conditions of the interstellar medium in the LMC massive star-forming complex N11 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-12-26
    Description: We combine Spitzer and Herschel data of the star-forming region N11 in the Large Magellanic Cloud (LMC) to produce detailed maps of the dust properties in the complex and study their variations with the interstellar-medium conditions. We also compare Atacama Pathfinder EXperiment/Large APEX Bolometer Camera (APEX/LABOCA) 870 μm observations with our model predictions in order to decompose the 870 μm emission into dust and non-dust [free–free emission and CO(3–2) line] contributions. We find that in N11, the 870 μm can be fully accounted for by these three components. The dust surface density map of N11 is combined with H  i and CO observations to study local variations in the gas-to-dust mass ratios. Our analysis leads to values lower than those expected from the LMC low-metallicity as well as to a decrease of the gas-to-dust mass ratio with the dust surface density. We explore potential hypotheses that could explain the low ‘observed’ gas-to-dust mass ratios (variations in the X CO factor, presence of CO-dark gas or of optically thick H  i or variations in the dust abundance in the dense regions). We finally decompose the local spectral energy distributions (SEDs) using a principal component analysis (i.e. with no a priori assumption on the dust composition in the complex). Our results lead to a promising decomposition of the local SEDs in various dust components (hot, warm, cold) coherent with that expected for the region. Further analysis on a larger sample of galaxies will follow in order to understand how unique this decomposition is or how it evolves from one environment to another.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 5
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    Six-Step Syntheses of (−)-1-Deoxyaltronojirimycin and (+)-1-Deoxymannonojirimycin from N-Z-O-TBDPS-l-serinal (2016)
    American Chemical Society (ACS)
    Details
    Publication Date: 2016-08-20
    Description: The Journal of Organic Chemistry DOI: 10.1021/acs.joc.6b01575
    Print ISSN: 0022-3263
    Electronic ISSN: 1520-6904
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 6
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    Pressure dependence of the superconducting transition temperature of the filled skutterudite YFe_{4}P_{12} (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-07-26
    Description: Author(s): J.-G. Cheng, J.-S. Zhou, K. Matsubayashi, P. P. Kong, Y. Kubo, Y. Kawamura, C. Sekine, C. Q. Jin, J. B. Goodenough, and Y. Uwatoko We have studied the pressure dependence of the superconducting transition temperature T c of the filled skutterudite YFe 4 P 12 under various quasihydrostatic pressures up to 8 GPa. DC magnetization measurements up to 1.2 GPa in a piston-cylinder cell yields a linear increase of T c with a positive coeff... [Phys. Rev. B 88, 024514] Published Thu Jul 25, 2013
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-09
    Description: RNA silencing is a conserved mechanism in which small RNAs trigger various forms of sequence-specific gene silencing by guiding Argonaute complexes to target RNAs by means of base pairing. RNA silencing is thought to have evolved as a form of nucleic-acid-based immunity to inactivate viruses and transposable elements. Although the activity of transposable elements in animals has been thought largely to be restricted to the germ line, recent studies have shown that they may also actively transpose in somatic cells, creating somatic mosaicism in animals. In the Drosophila germ line, Piwi-interacting RNAs arise from repetitive intergenic elements including retrotransposons by a Dicer-independent pathway and function through the Piwi subfamily of Argonautes to ensure silencing of retrotransposons. Here we show that, in cultured Drosophila S2 cells, Argonaute 2 (AGO2), an AGO subfamily member of Argonautes, associates with endogenous small RNAs of 20-22 nucleotides in length, which we have collectively named endogenous short interfering RNAs (esiRNAs). esiRNAs can be divided into two groups: one that mainly corresponds to a subset of retrotransposons, and the other that arises from stem-loop structures. esiRNAs are produced in a Dicer-2-dependent manner from distinctive genomic loci, are modified at their 3' ends and can direct AGO2 to cleave target RNAs. Mutations in Dicer-2 caused an increase in retrotransposon transcripts. Together, our findings indicate that different types of small RNAs and Argonautes are used to repress retrotransposons in germline and somatic cells in Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kawamura, Yoshinori -- Saito, Kuniaki -- Kin, Taishin -- Ono, Yukiteru -- Asai, Kiyoshi -- Sunohara, Takafumi -- Okada, Tomoko N -- Siomi, Mikiko C -- Siomi, Haruhiko -- England -- Nature. 2008 Jun 5;453(7196):793-7. doi: 10.1038/nature06938. Epub 2008 May 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18463636" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Argonaute Proteins ; Cell Line ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/*cytology/enzymology/genetics/*metabolism ; Eukaryotic Initiation Factors ; Germ Cells/metabolism ; Mosaicism ; Polymerase Chain Reaction ; Protein Binding ; RNA Helicases/genetics/metabolism ; RNA Interference ; RNA, Small Interfering/genetics/*metabolism ; RNA-Induced Silencing Complex/*metabolism ; Retroelements/genetics ; Ribonuclease III
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-10-09
    Description: PIWI-interacting RNAs (piRNAs) silence retrotransposons in Drosophila germ lines by associating with the PIWI proteins Argonaute 3 (AGO3), Aubergine (Aub) and Piwi. piRNAs in Drosophila are produced from intergenic repetitive genes and piRNA clusters by two systems: the primary processing pathway and the amplification loop. The amplification loop occurs in a Dicer-independent, PIWI-Slicer-dependent manner. However, primary piRNA processing remains elusive. Here we analysed piRNA processing in a Drosophila ovarian somatic cell line where Piwi, but not Aub or AGO3, is expressed; thus, only the primary piRNAs exist. In addition to flamenco, a Piwi-specific piRNA cluster, traffic jam (tj), a large Maf gene, was determined as a new piRNA cluster. piRNAs arising from tj correspond to the untranslated regions of tj messenger RNA and are sense-oriented. piRNA loading on to Piwi may occur in the cytoplasm. zucchini, a gene encoding a putative cytoplasmic nuclease, is required for tj-derived piRNA production. In tj and piwi mutant ovaries, somatic cells fail to intermingle with germ cells and Fasciclin III is overexpressed. Loss of tj abolishes Piwi expression in gonadal somatic cells. Thus, in gonadal somatic cells, tj gives rise simultaneously to two different molecules: the TJ protein, which activates Piwi expression, and piRNAs, which define the Piwi targets for silencing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saito, Kuniaki -- Inagaki, Sachi -- Mituyama, Toutai -- Kawamura, Yoshinori -- Ono, Yukiteru -- Sakota, Eri -- Kotani, Hazuki -- Asai, Kiyoshi -- Siomi, Haruhiko -- Siomi, Mikiko C -- England -- Nature. 2009 Oct 29;461(7268):1296-9. doi: 10.1038/nature08501. Epub 2009 Oct 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Keio University School of Medicine, Tokyo 160-8582, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19812547" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Argonaute Proteins ; Cell Adhesion Molecules, Neuronal/metabolism ; Cell Line ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/genetics/*metabolism ; Endoribonucleases/metabolism ; Female ; Genes, Insect/genetics ; Genetic Loci/genetics ; Maf Transcription Factors, Large/genetics/*metabolism ; Male ; Ovary/cytology/metabolism ; Phenotype ; Proto-Oncogene Proteins/genetics/*metabolism ; RNA/biosynthesis/genetics/*metabolism ; RNA Interference ; RNA Processing, Post-Transcriptional ; RNA-Induced Silencing Complex/genetics/*metabolism ; Testis/cytology/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Ferromagnetic spin fluctuations in the filled skutterudite ${\mathrm{SrFe}}_{4}{\mathrm{As}}_{12}$ revealed by $^{75}\mathrm{As}$ NMR-NQR measurements (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-11-01
    Description: Author(s): Q.-P. Ding, K. Rana, K. Nishine, Y. Kawamura, J. Hayashi, C. Sekine, and Y. Furukawa As 75 nuclear magnetic resonance (NMR) and nuclear quadrupole resonance (NQR) measurements have been carried out to investigate the magnetic and electronic properties of the filled skutterudite metallic compound SrFe 4 As 12 . The temperature dependence of Knight shift K determined by the NQR spectrum un... [Phys. Rev. B 98, 155149] Published Wed Oct 31, 2018
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1 (2011)
    Nature Publishing Group (NPG)
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    Publication Date: 2011-06-10
    Description: Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the transgenic expression of three transcription factors collectively called OSK: Oct3/4 (also called Pou5f1), Sox2 and Klf4. However, the conversion to iPSCs is inefficient. The proto-oncogene Myc enhances the efficiency of iPSC generation by OSK but it also increases the tumorigenicity of the resulting iPSCs. Here we show that the Gli-like transcription factor Glis1 (Glis family zinc finger 1) markedly enhances the generation of iPSCs from both mouse and human fibroblasts when it is expressed together with OSK. Mouse iPSCs generated using this combination of transcription factors can form germline-competent chimaeras. Glis1 is enriched in unfertilized oocytes and in embryos at the one-cell stage. DNA microarray analyses show that Glis1 promotes multiple pro-reprogramming pathways, including Myc, Nanog, Lin28, Wnt, Essrb and the mesenchymal-epithelial transition. These results therefore show that Glis1 effectively promotes the direct reprogramming of somatic cells during iPSC generation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maekawa, Momoko -- Yamaguchi, Kei -- Nakamura, Tomonori -- Shibukawa, Ran -- Kodanaka, Ikumi -- Ichisaka, Tomoko -- Kawamura, Yoshifumi -- Mochizuki, Hiromi -- Goshima, Naoki -- Yamanaka, Shinya -- England -- Nature. 2011 Jun 8;474(7350):225-9. doi: 10.1038/nature10106.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21654807" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured ; *Cellular Reprogramming ; DNA-Binding Proteins/*metabolism ; Embryonic Stem Cells/cytology/metabolism ; Epithelial-Mesenchymal Transition ; Female ; Fibroblasts/*cytology/*metabolism ; Gene Expression Profiling ; Genes, myc/genetics ; Hepatocyte Nuclear Factor 3-beta/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Induced Pluripotent Stem Cells/*cytology/*metabolism ; Mice ; Nuclear Transfer Techniques ; Oligonucleotide Array Sequence Analysis ; Protein Binding ; RNA-Binding Proteins/metabolism ; Receptors, Estrogen/metabolism ; Transcription Factors/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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