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  • 1
    Electronic Resource
    Electronic Resource
    Extensive genomic duplication during early chordate evolution (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 31 (2002), S. 200-204 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Opinions on the hypothesis that ancient genome duplications contributed to the vertebrate genome range from strong skepticism to strong credence. Previous studies concentrated on small numbers of gene families or chromosomal regions that might not have been representative of the whole genome, or ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng884
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular evolution meets the genomics revolution (2003)
    [s.l.] : Nature Publishing Group
    Nature genetics 33 (2003), S. 255-265 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Changes in technology in the past decade have had such an impact on the way that molecular evolution research is done that it is difficult now to imagine working in a world without genomics or the Internet. In 1992, GenBank was less than a hundredth of its current size and was updated every three ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1088
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  • 3
    Electronic Resource
    Electronic Resource
    Birth of a metabolic gene cluster in yeast by adaptive gene relocation (2005)
    [s.l.] : Nature Publishing Group
    Nature genetics 37 (2005), S. 777-782 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Although most eukaryotic genomes lack operons, they contain some physical clusters of genes that are related in function despite being unrelated in sequence. How these clusters are formed during evolution is unknown. The DAL cluster is the largest metabolic gene cluster in yeast and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1584
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  • 4
    Electronic Resource
    Electronic Resource
    Positive darwinian selection at the imprinted MEDEA locus in plants (2007)
    [s.l.] : Nature Publishing Group
    Nature 448 (2007), S. 349-352 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In mammals and seed plants, a subset of genes is regulated by genomic imprinting where an allele’s activity depends on its parental origin. The parental conflict theory suggests that genomic imprinting evolved after the emergence of an embryo-nourishing tissue (placenta and endosperm), ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05984
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  • 5
    Electronic Resource
    Electronic Resource
    Molecular evidence for an ancient duplication of the entire yeast genome (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 387 (1997), S. 708-713 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Gene duplication is an important source of evolutionary novelty,. Most duplications are of just a single gene, but Ohno proposed that whole-genome duplication (polyploidy) is an important evolutionary mechanism. Many duplicate genes have been found in Saccharomyces cerevisiae, and these often ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/387708a0
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  • 6
    Electronic Resource
    Electronic Resource
    Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts (2006)
    [s.l.] : Nature Publishing Group
    Nature 440 (2006), S. 341-345 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A whole-genome duplication occurred in a shared ancestor of the yeast species Saccharomyces cerevisiae, Saccharomyces castellii and Candida glabrata. Here we trace the subsequent losses of duplicated genes, and show that the pattern of loss differs among the three species at 20% of all loci. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04562
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  • 7
    Electronic Resource
    Electronic Resource
    The site of deletion of the inverted repeat in pea chloroplast DNA contains duplicated gene fragments (1988)
    Springer
    Current genetics 13 (1988), S. 97-99 
    Details
    ISSN: 1432-0983
    Keywords: Chloroplast DNA ; Inverted repeat ; Deletion ; Duplication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Analysis of a nucleotide sequence from pea chloroplast DNA which spans the site of deletion of one copy of the large inverted repeat (IR) element suggests that the IR unit has been entirely deleted, but that the single-copy coding sequences which flanked it (trnH and ndh5) have been left intact. However, these flanking sequences have not simply been ligated together: between them there is instead a novel ∼200 by DNA sequence which includes two regions apparently derived by the duplication of fragments of the psbA and rbcL genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365763
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  • 8
    Electronic Resource
    Electronic Resource
    Base Composition Skews, Replication Orientation, and Gene Orientation in 12 Prokaryote Genomes (1998)
    Springer
    Journal of molecular evolution 47 (1998), S. 691-696 
    Details
    ISSN: 1432-1432
    Keywords: Key words: Base composition — Skews — Replication orientation — Gene orientation — Prokaryote genomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Variation in GC content, GC skew and AT skew along genomic regions was examined at third codon positions in completely sequenced prokaryotes. Eight out of nine eubacteria studied show GC and AT skews that change sign at the origin of replication. The leading strand in DNA replication is G-T rich at codon position 3 in six eubacteria, but C-T rich in two Mycoplasma species. In M. genitalium the AT and GC skews are symmetrical around the origin and terminus of replication, whereas its GC content variation has been shown to have a centre of symmetry elsewhere in the genome. Borrelia burgdorferi and Treponema pallidum show extraordinary extents of base composition skew correlated with direction of DNA replication. Base composition skews measured at third codon positions probably reflect mutational biases, whereas those measured over all bases in a sequence (or at codon positions 1 and 2) can be strongly affected by protein considerations due to the tendency in some bacteria for genes to be transcribed in the same direction that they are replicated. Consequently in some species the direction of skew for total genomic DNA is opposite to that for codon position 3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006428
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  • 9
    Electronic Resource
    Electronic Resource
    Gene Duplication and Gene Conversion in the Caenorhabditis elegans Genome (1999)
    Springer
    Journal of molecular evolution 48 (1999), S. 555-564 
    Details
    ISSN: 1432-1432
    Keywords: Key words:Caenorhabditis elegans— Duplication — Gene conversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. A comprehensive analysis of duplication and gene conversion for 7394 Caenorhabditis elegans genes (about half the expected total for the genome) is presented. Of the genes examined, 40% are involved in duplicated gene pairs. Intrachromosomal or cis gene duplications occur approximately two times more often than expected. In general the closer the members of duplicated gene pairs are, the more likely it is that gene orientation is conserved. Gene conversion events are detectable between only 2% of the duplicated pairs. Even given the excesses of cis duplications, there is an excess of gene conversion events between cis duplicated pairs on every chromosome except the X chromosome. The relative rates of cis and trans gene conversion and the negative correlation between conversion frequency and DNA sequence divergence for unconverted regions of converted pairs are consistent with previous experimental studies in yeast. Three recent, regional duplications, each spanning three genes are described. All three have already undergone substantial deletions spanning hundreds of base pairs. The relative rates of duplication and deletion may contribute to the compactness of the C. elegans genome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006498
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  • 10
    Electronic Resource
    Electronic Resource
    Rates of synonymous substitution in plant nuclear genes (1989)
    Springer
    Journal of molecular evolution 29 (1989), S. 208-211 
    Details
    ISSN: 1432-1432
    Keywords: Plant molecular evolution ; Molecular clock ; Chloroplast DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The rate of synonymous nucleotide substitution in nuclear genes of higher plants has been estimated. The rate varies among genes by a factor of up to two, in a manner that is not immediately explicable in terms of base composition or codon usage bias. The average rate, in both monocots and dicots, is about four times higher than that in chloroplast genes. This leads to an estimated absolute silent substitution rate of 6 × 10−9 substitutions per site per year that falls within the range of average rates (2−8 × 10−9) seen in different mammalian nuclear genomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02100204
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