Publication Date:
2015-03-11
Description:
Article Frequencies of rare variants fluctuate over populations, hampering gene discovery. Here the authors use a population-specific reference panel, the Genome of the Netherlands, to discover four novel loci involved in lipid metabolism, including an exonic variant in ABCA6 . Nature Communications doi: 10.1038/ncomms7065 Authors: Elisabeth M. van Leeuwen, Lennart C. Karssen, Joris Deelen, Aaron Isaacs, Carolina Medina-Gomez, Hamdi Mbarek, Alexandros Kanterakis, Stella Trompet, Iris Postmus, Niek Verweij, David J. van Enckevort, Jennifer E. Huffman, Charles C. White, Mary F. Feitosa, Traci M. Bartz, Ani Manichaikul, Peter K. Joshi, Gina M. Peloso, Patrick Deelen, Freerk van Dijk, Gonneke Willemsen, Eco J. de Geus, Yuri Milaneschi, Brenda W.J.H. Penninx, Laurent C. Francioli, Androniki Menelaou, Sara L. Pulit, Fernando Rivadeneira, Albert Hofman, Ben A. Oostra, Oscar H. Franco, Irene Mateo Leach, Marian Beekman, Anton J.M. de Craen, Hae-Won Uh, Holly Trochet, Lynne J. Hocking, David J. Porteous, Naveed Sattar, Chris J. Packard, Brendan M. Buckley, Jennifer A. Brody, Joshua C. Bis, Jerome I. Rotter, Josyf C. Mychaleckyj, Harry Campbell, Qing Duan, Leslie A. Lange, James F. Wilson, Caroline Hayward, Ozren Polasek, Veronique Vitart, Igor Rudan, Alan F. Wright, Stephen S. Rich, Bruce M. Psaty, Ingrid B. Borecki, Patricia M. Kearney, David J. Stott, L. Adrienne Cupples, J. Wouter Jukema, Pim van der Harst, Eric J. Sijbrands, Jouke-Jan Hottenga, Andre G. Uitterlinden, Morris A. Swertz, Gert-Jan B. van Ommen, Paul I.W. de Bakker, P. Eline Slagboom, Dorret I. Boomsma, Cisca Wijmenga, Cornelia M. van Duijn
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
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Natural Sciences in General
,
Physics
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