ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The macrolide antibiotic amphotericin B (AmB) forms an inclusion complex with γ-cyclodextrin (γ-CDx), resulting in a molecularly dispersed state of the drug. The state of aggregation of AmB in different solvents has been studied by absorption (uv-vis) and CD spectroscopy. While in aqueous solutions AmB forms colloid-like multimolecular aggregates, in the presence of γ-CDx true solutions can be prepared, which show similar spectral properties as AmB dissolved in organic solvents. The AmB-γ-CDx complex can be isolated as an amorphous, stable, water-soluble powder, indicatin that γ-CDx is a good carrier for the solubilization of this antibiotic. Using γ-CDx as a carrier, the danger of precipitation of the drug during parenteral or intravenous administration can be largely reduced.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.360280908
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