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  • 1
    Electronic Resource
    Electronic Resource
    Mixing in liquid-impelled loop reactors (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 39 (1992), S. 707-716 
    Details
    ISSN: 0006-3592
    Keywords: Mixing ; two phase ; bioreactor ; perfluorochemical ; LLR ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The liquid-impelled loop reactor is a new column-type bioreactor. The design of this device is based on the principle of the air-lift loop reactor. In the external-loop configuration used in this work, descending perfluorochemical drops bring about circulation of the continuous aqueous phase. Mixing of this continuous phase is characterized per section of the rector. Axial-dispersion coefficients for the tube with two-phase flow are determined and correlated with the energy dissipation in the tube. Comparisons with similar systems such as bubble columns and air-lift loop reactors are made. Overall mixing parameters are derived and used for calculation of the number of circulatins needed to achieve a certain degree of mixing. The hydrodynamic model from previous work is tested for the reactor configurations of this work. It can be useful to calculate circulation times.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260390703
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  • 2
    Electronic Resource
    Electronic Resource
    Hydrodynamic model for liquid-impelled loop reactorsPatent pending. (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 36 (1990), S. 940-946 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new type of bioreactor, in which two liquid phases are used, is introduced and a model description of its hydrodynamic behavior is given. The model is based on the two-phase drift-flux model of Zuber and Findlay and on a friction coefficient derived from one-phase flow theory. Drop sizes, necessary for model calculations, were estimated from literature correlations and photographically verified. The model predicts the continuous-phase circulation velocity and dispersed-phase hold-up within an accuracy of 5% for a pilot-plant reactor, and within 10% for a lab-scale reactor. Only at very low ranges, especially on lab scale, is this accuracy not attained.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260360909
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  • 3
    Electronic Resource
    Electronic Resource
    Oxygen transfer in liquid-impelled loop reactors using perfluorocarbon liquids (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 40 (1992), S. 713-718 
    Details
    ISSN: 0006-3592
    Keywords: oxygen transfer ; liquid-impelled loop reactor ; perfluorocarbon ; two-liquid-phase ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Oxygen transfer in the liquid-impelled loop reactor is described for a setup in which the perfluorochemical FC40 is aerated externally. Two sizes of reactors are investigated. The mass-transfer coefficient k appears to be lower with a factor of about 0.6 compared to gas liquid systems. the specific exchange area in the present experimental setup is found to be favorable when compared with gas liquid bioreactors at the same superficial dispersed-phase velocities. However, slow coalescence of the dispersed-phase drops in the phase separation section limits the dispersed-phase flow rate seriously. In Case this become crucial from the point of view of oxygen supply, special measures need to be found or alternatives such as combined sparging of air and solvent. © 1992 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260400610
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