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  • 1
    Electronic Resource
    Electronic Resource
    Tumor inhibitors. LVII. Reaction of endocyclic .alpha.,.beta.-unsaturated .gamma.-lactones with thiols (1970)
    s.l. : American Chemical Society
    The @journal of organic chemistry 35 (1970), S. 3539-3543 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00835a078
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation of a secY homologue from Bacillus subtilis: evidence for a common protein export pathway in eubacteria (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Genetic and biochemical studies have shown that the product of the Escherichia coli secY gene is an integral membrane protein with a central role in protein secretion. We found the Bacillus subtilis secY homologue within the spc-alpha ribosomal protein operon at the same position occupied by E. coli secY. B. subtilis secY coded for a hypothetical product 41% identical to E. coli SecY, a protein thought to contain 10 membrane-spanning segments and 11 hydrophilic regions, six of which are exposed to the cytoplasm and five to the periplasm. We predicted similar segments in B. subtilis SecY, and the primary sequences of the second and third cytoplasmic regions and the first, second, fourth, fifth, seventh, and tenth membrane segments were particularly conserved, sharing greater than 50% identity with E. coli SecY. We propose that the conserved cytoplasmic regions interact with similar cytoplasmic secretion factors in both organisms and that the conserved membrane-spanning segments actively participate in protein export. Our results suggest that despite the evolutionary differences reflected in cell wall architecture, Gram-negative and Gram-positive bacteria possess a similar protein export apparatus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00597.x
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  • 3
    Electronic Resource
    Electronic Resource
    Importance of Sensory Evaluation in the Stability Testing of a Medical Food (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 46 (1981), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A medical food was formulated as a dry powder product containing free essential amino acids, fat and carbohydrates. Samples were stored at 4°C, 25°C, and 40°C and evaluated periodically during storage. Proximate analysis, pH, amino acid analysis, osmolarity, emulsion stability, Hunter color difference, and sensory evaluation tests were performed. Changes could not be detected by the chemical tests employed, but were manifested in sensory analysis. This study indicated that sensory testing of medical foods is a critical tool in the assessment of product stability and must be considered an integral part of any medical food stability program. Chemical analysis alone will not provide sufficient data to allow prediction of either patient acceptance or product integrity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1981.tb04879.x
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  • 4
    Electronic Resource
    Electronic Resource
    Plant DNA patents in the hands of a few (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 399 (1999), S. 405-406 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SirConsolidation in the agrochemical and seed industry continues to shorten the list of owners of ‘enabling’ intellectual property for plant genetic modification and molecular biology. Six major groups of multinational companies are poised to develop and patent ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/20786
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  • 5
    Electronic Resource
    Electronic Resource
    Public-sector patents on human DNA (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 388 (1997), S. 709-709 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir The increasing emphasis of genomics in therapeutic and diagnostic research and development (R&D) suggests a continuing dominant role for the pharmaceutical industry in patenting human DNA. Here we present new data that challenge this broadly accepted trend by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/388709a0
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  • 6
    Electronic Resource
    Electronic Resource
    The Euclidean Memory Array — A vector quantisation technique for the processing of data from interview forms (1994)
    Springer
    Neural computing & applications 2 (1994), S. 53-57 
    Details
    ISSN: 1433-3058
    Keywords: Euclidean ; Interview ; Kohonen ; Network ; Quantisation ; Self-organising
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract In this paper, work that has been carried out on the processing of data derived from interview forms is discussed. Various attempts have been made to process the data using Kohonen self-organising maps. The object of the processing was to identify both local and global trends within the data sets. The difficulty encountered in training the networks and interpreting the results led to the development of a new vector quantisation network, the ‘Euclidean Memory Array’, a network made distinct by the lack of a conventional learning process. This technique provided a valuable insight into the trends within the data, proving effective even on extremely small data sets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01423098
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  • 7
    Electronic Resource
    Electronic Resource
    A Neural Network Approach to Predicting Airspeed in Helicopters (2000)
    Springer
    Neural computing & applications 9 (2000), S. 73-82 
    Details
    ISSN: 1433-3058
    Keywords: Keywords:Airspeed; Helicopter; Multi-layer perceptron; Sideslip angle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: A helicopter’s airspeed and sideslip angle is difficult to measure at speeds below 50 knots. This paper describes the application of Artificial Neural Network (ANN) techniques to the helicopter low air-speed problem. Three ANN methods were applied to the problem: a linear network, a Radial Basis Function (RBF) network, and a Multi-Layer Perceptron (MLP), trained using an implementation of the Levenberg–Marquardt (L–M) algorithm. Internally available measurements, such as control positions and body attitudes and rates, were generated using a realistic simulation model of a Lynx helicopter. These measurements formed the inputs to the ANN methods. The MLP was found to be the superior method. Further testing, including a Tagu-chi analysis, indicated the validity of the method. It is concluded that ANN techniques present a promising solution to the helicopter low airspeed problem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005210070018
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  • 8
    Electronic Resource
    Electronic Resource
    Ownership of the human genome (1996)
    [s.l.] : Nature Publishing Group
    Nature 380 (1996), S. 387-388 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE patenting of human DNA sequences is the most controversial aspect of the Human Genome Project (HGP). Academic scientists strive to increase knowledge and to publish their findings. Companies, on the other hand, regard the exclusivity gained through patenting as essential to successful ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/380387a0
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  • 9
    Electronic Resource
    Electronic Resource
    C4 photosynthesis in Spartina townsendii at low and high temperatures (1978)
    Springer
    Planta 142 (1978), S. 171-174 
    Details
    ISSN: 1432-2048
    Keywords: C4 plants ; Photosynthesis (and temperature) ; Spartina ; Temperature (photosynthesis)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The metabolism of 14CO2 in the cool temperate saltmarsh grass Spartina townsendii was investigated in plants grown in their natural habitats at two temperatures. Both in the spring at 10°C and in the late summer at 25°C radioactivity was initially incorporated into the organic acids malate and aspartate and then transferred to 3-phosphoglycerate in the manner characteristic of the C4 pathway of photosynthesis. Metabolism was not disrupted at the lower temperature as in some C4 plants. Radioactivity was transferred more slowly from malate into alanine, glycine and serine at 10°C, but sugars were labelled equally at both temperatures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388208
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  • 10
    Electronic Resource
    Electronic Resource
    Unbiased Estimates of Circle Parameters (2000)
    Springer
    Journal of optimization theory and applications 106 (2000), S. 49-60 
    Details
    ISSN: 1573-2878
    Keywords: Circle fitting ; instrumental variables ; Fisher scoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract It is of practical value to estimate the center and radius of a circle from a given set of noisy coordinate measurements. Since the coordinates of the points on a circle relate to its parameters through the nonlinear circle equation, the estimation problem is inherently nonlinear. Additionally, if the measurements are available only along a small arc, the estimation exhibits generally a bias, together with large variances, even at low-noise magnitudes. This paper presents two algorithms, one iterative and another which has a closed-form solution, aiming at the elimination of biases that occur at small arcs. Simulation results show that the two algorithms do provide unbiased and reliable estimates of the circle parameters for noisy measurements on arcs as small as 45°.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004603023018
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