Publication Date:
2022-05-25
Description:
Author Posting. © Marine Biological Laboratory, 2009. This article is posted here by permission of Marine Biological Laboratory for personal use, not for redistribution. The definitive version was published in Biological Bulletin 216 (2009): 1-6.
Description:
The squid giant synapse is a well-defined experimental preparation for the study of ligand-dependant synaptic transmission. Its large size gives direct experimental access to both presynaptic and postsynaptic junctional elements, allowing direct optical, biophysical, and electrophysiological analysis of depolarization-release coupling. However, this important model has not been utilized in pharmacological studies, other than those implementable acutely in the in vitro condition. A method is presented for oral administration of bioactive substances to living squid. Electrophysiological characterization and direct determination of drug absorption into the nervous system demonstrate the administration method described here to be appropriate for pharmacological research.
Description:
The studies were supported by National Institute of
Health Grant NS13742 (to RLL and MS).
Keywords:
HPLC
;
High performance liquid chromatography
;
MPP+, 1-methyl-4-phenylpyridinium
Repository Name:
Woods Hole Open Access Server
Type:
Article
Format:
application/pdf
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