Publication Date:
2018-08-25
Description:
Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes, Published online: 24 August 2018; doi:10.1038/s41467-018-05979-8 Necroptosis has immunogenic cell death properties. Here, the authors show that the intra-tumor delivery of mRNA that codes for the necroptosis effector MLKL triggers neo-epitope-specific anti-tumor T cell responses and inhibits primary tumor growth and lung metastasis.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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