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  • 1
    Electronic Resource
    Electronic Resource
    Extremely high circulating levels of 1α,25-dihydroxyvitamin D"3 in the marmoset, a new world monkey
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 114 (1983), S. 452-457 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(83)90801-X
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  • 2
    Electronic Resource
    Electronic Resource
    Generation of Tsunamis in the Okhotsk Sea Caused by the 1994 Great Kuril Earthquake (2000)
    Springer
    Pure and applied geophysics 157 (2000), S. 977-988 
    Details
    ISSN: 1420-9136
    Keywords: Key Words: The 1994 Kuril tsunami, tsunami generation, numerical simulation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —The 1994 great Kuril earthquake generated an unusual tsunami that was observed at five tide gauges on the Hokkaido coast of the Okhotsk Sea. The tsunami arrived at tide gauges considerably earlier than the expected time, calculated on the assumption that the tsunami source area coincides with the aftershock area. Numerical simulation of the tsunami shows that the first wave of the tsunami in the Okhotsk Sea was generated by the significant subsidence north of the Kuril Islands. It is assumed that this subsidence is due to the earthquake. The coseismic deformation area of the ocean bottom extended over a vastly larger area than the aftershock area or the rupture area for the Kuril earthquake. The numerical simulation also shows that the tsunami observed at Utoro during the first hour after the origin time of the earthquake was mainly generated by the horizontal movement of the sloping ocean bottom near the Shiretoko Peninsula.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000240050013
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  • 3
    Electronic Resource
    Electronic Resource
    Sources of Tsunami and Tsunamigenic Earthquakes in Subduction Zones (1999)
    Springer
    Pure and applied geophysics 154 (1999), S. 467-483 
    Details
    ISSN: 1420-9136
    Keywords: Key words: Tsunami, subduction zones, interplate earthquakes, intraplate earthquakes, tsunami earthquakes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —We classified tsunamigenic earthquakes in subduction zones into three types earth quakes at the plate interface (typical interplate events), earthquakes at the outer rise, within the subducting slab or overlying crust (intraplate events), and "tsunami earthquakes" that generate considerably larger tsunamis than expected from seismic waves. The depth range of a typical interplate earthquake source is 10–40km, controlled by temperature and other geological parameters. The slip distribution varies both with depth and along-strike. Recent examples show very different temporal change of slip distribution in the Aleutians and the Japan trench. The tsunamigenic coseismic slip of the 1957 Aleutian earthquake was concentrated on an asperity located in the western half of an aftershock zone 1200km long. This asperity ruptured again in the 1986 Andreanof Islands and 1996 Delarof Islands earthquakes. By contrast, the source of the 1994 Sanriku-oki earthquake corresponds to the low slip region of the previous interplate event, the 1968 Tokachi-oki earthquake. Tsunamis from intraplate earthquakes within the subducting slab can be at least as large as those from interplate earthquakes; tsunami hazard assessments must include such events. Similarity in macroseismic data from two southern Kuril earthquakes illustrates difficulty in distinguishing interplate and slab events on the basis of historical data such as felt reports and tsunami heights. Most moment release of tsunami earthquakes occurs in a narrow region near the trench, and the concentrated slip is responsible for the large tsunami. Numerical modeling of the 1996 Peru earthquake confirms this model, which has been proposed for other tsunami earthquakes, including 1896 Sanriku, 1946 Aleutian and 1992 Nicaragua.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000240050240
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  • 4
    Electronic Resource
    Electronic Resource
    Allelic diversity at class II DRB1 and DQB loci of the pig MHC (SLA) (1999)
    Springer
    Immunogenetics 50 (1999), S. 295-300 
    Details
    ISSN: 1432-1211
    Keywords: Key words MHC class II ; Generation of diversity ; SLA-DRB1 ; SLA-DQB ; Sequence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The loci encoding the β chain of the pig major histocompatibility complex (MHC) class II antigens, SLA-DR and -DQ, have been known to exhibit a remarkable degree of allelic polymorphism. Here, to understand the generation of SLA class II polymorphism, 25 SLA-DRB1 and 24 SLA-DQB genes including newly identified 12 SLA-DRB1 and 7 SLA-DQB genes obtained from miniature pigs were analyzed based on the nucleotide and deduced amino acid sequences. Most of the allelic diversity was attributed to the variable sequences which encode a β1 domain consisting of a β-pleated sheet followed by an α helix. In the β1 domain coding region, there were four GC-rich sequences, which have been considered to involve the intra-exon sequence exchange also in other gene evolutions. The first and second GC-rich sequences were χ-like sequences, which have been shown to be a putative recombination signal, and were stably conserved among SLA-DRB1 and DQB genes. These χ-like sequences identified in SLA-DRB1 and SLA-DQB were found to encode the first turning point of the β-pleated sheet and the boundary between the β-pleated sheet and the α helix. Analysis of clustered sequence variation also suggested intra-exon gene conversions in which the χ-like sequences act as putative breakpoints. In addition to point mutations and selection mechanism, intra-exon gene conversions must be an important mechanism in the generation of allelic polymorphism at the SLA-DRB1 and SLA-DQB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050605
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  • 5
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    The primary structure of the myosin head. (1987)
    National Academy of Sciences
    Details
    Publication Date: 1987-01-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 6
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    Comparison of Earthquake Source Models for the 2011 Tohoku Event Using Tsunami Simulations and Near-Field Observations (2013)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2013-05-03
    Description: Selection of the earthquake source used in tsunami models of the 2011 Tohoku event affects the simulated tsunami waveform across the near field. Different earthquake sources, based on inversions of seismic waveforms, tsunami waveforms, and Global Positioning System (GPS) data, give distinguishable patterns of simulated tsunami heights in many locations in Tohoku and at near-field Deep-ocean Assessment and Reporting of Tsunamis (DART) buoys. We compared 10 sources proposed by different research groups using the GeoClaw code to simulate the resulting tsunami. Several simulations accurately reproduced observations at simulation sites with high grid resolution. Many earthquake sources produced results within 20% difference from the observations between 38° and 39° N, including realistic inundation on the Sendai plain, reflecting a common reliance on large initial seafloor uplift around 38° N (±0.5°), 143.25° E (±0.75°). As might be expected, DART data was better reproduced by sources created by inversion techniques that incorporated DART data in the inversion. Most of the earthquake sources tested at sites with high grid resolution were unable to reproduce the magnitude of runup north of 39° N, indicating that an additional source of tsunamigenic energy, not present in most source models, is needed to explain these observations. Online Material: Figures of buoy, inundation and run-up simulations and observations, associated data sets, and simulation code.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America (SSA)
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  • 7
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    Allelic diversity at class II DRB1 and DQB loci of the pig MHC ( SLA ) (1999)
    Springer
    Details
    Publication Date: 1999-12-02
    Print ISSN: 0093-7711
    Electronic ISSN: 1432-1211
    Topics: Biology , Medicine
    Published by Springer
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  • 8
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    In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets (1990)
    American Society of Hematology
    Details
    Publication Date: 1990-04-15
    Description: In cynomolgus monkeys, twice daily subcutaneous injections of recombinant human interleukin-6 (rhIL-6) at doses of 5 to 80 micrograms/kg/d for 14 consecutive days caused dose-dependent increases in platelet count, usually continuing for more than 1 week after cessation of the injections. The count reached a level approximately twofold or more above the preinjection level even at 5 micrograms/kg/d, and at doses of more than 20 micrograms/kg/d, the increase became biphasic with a higher second peak 3 days after cessation of the injections. Morphologic analysis of the bone marrow after the 7 day- injections with 80 micrograms/kg/d revealed a marked increment in size of megakaryocytes compared with control, indicating the promotion of megakaryocyte maturation. Other changes attributable to the rhIL-6 treatment include dose-dependent loss of body weight, anemia, neutrophilia and monocytosis, elevation of serum C-reactive protein and alpha-1 acid glycoprotein levels, and decrease of serum albumin; all of which returned to normal within 1 week after cessation of the injections and were tolerable at doses of less than 10 micrograms/kg/d. These findings suggest that rhIL-6 may be an effective strategy for the treatment of thrombocytopenia.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 9
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    In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets (1990)
    American Society of Hematology
    Details
    Publication Date: 1990-04-15
    Description: In cynomolgus monkeys, twice daily subcutaneous injections of recombinant human interleukin-6 (rhIL-6) at doses of 5 to 80 micrograms/kg/d for 14 consecutive days caused dose-dependent increases in platelet count, usually continuing for more than 1 week after cessation of the injections. The count reached a level approximately twofold or more above the preinjection level even at 5 micrograms/kg/d, and at doses of more than 20 micrograms/kg/d, the increase became biphasic with a higher second peak 3 days after cessation of the injections. Morphologic analysis of the bone marrow after the 7 day- injections with 80 micrograms/kg/d revealed a marked increment in size of megakaryocytes compared with control, indicating the promotion of megakaryocyte maturation. Other changes attributable to the rhIL-6 treatment include dose-dependent loss of body weight, anemia, neutrophilia and monocytosis, elevation of serum C-reactive protein and alpha-1 acid glycoprotein levels, and decrease of serum albumin; all of which returned to normal within 1 week after cessation of the injections and were tolerable at doses of less than 10 micrograms/kg/d. These findings suggest that rhIL-6 may be an effective strategy for the treatment of thrombocytopenia.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 10
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    Analysis of the Tsunami Generated by the Great 1977 Sumba Earthquake that Occurred in Indonesia (2009)
    Seismological Society of America
    Details
    Publication Date: 2009-07-29
    Description: The great outer-rise earthquake (M (sub w) 8.3) occurred near the Sunda trench, Indonesia, on 19 August 1977. The earthquake has been previously studied using seismological data. The earthquake generated a large tsunami that caused severe damage in Sumbawa and Sumba Islands in Indonesia. The tsunami was also observed at tide gauges in Australia. We numerically computed a far-field tsunami, and we compared the observed tsunami waveforms on three tide gauges with the computed waveforms. We also numerically computed the tsunami inundation and compared the observed tsunami run-up of 8 m and tsunami inundation distance of 500 m in Lunyuk on Sumbawa Island with the computed ones. To explain the observed tsunami waveforms, tsunami run-up, and tsunami inundation distance, the slip amount is found to be 3 m on the assumed fault model (with a fault length of 200 km and fault width of 70 km). The rigidity is assumed to range between 6.0 and 6.8X10 (super 10) N m (super -2) , and the range of the total seismic moment is calculated to be between 2.5 and 2.9X10 (super 21) N m (M (sub w) 8.2), which is similar to those estimated by the previous seismological studies. Additionally, we calculated the ratio between the observed tsunami run-up and the computed maximum tsunami height along the coastline of Lunyuk. This ratio, called the amplification factor, may possibly be used to roughly estimate the tsunami run-up from a tsunami numerical calculation result on a coarse grid system.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America
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