Publication Date:
2006-11-04
Description:
Iron deficiency is a major human nutritional problem wherever plant-based diets are common. Using synchrotron x-ray fluorescence microtomography to directly visualize iron in Arabidopsis seeds, we show that iron is localized primarily to the provascular strands of the embryo. This localization is completely abolished when the vacuolar iron uptake transporter VIT1 is disrupted. Vacuolar iron storage is also critical for seedling development because vit1-1 seedlings grow poorly when iron is limiting. We have uncovered a fundamental aspect of seed biology that will ultimately aid the development of nutrient-rich seed, benefiting both human health and agricultural productivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Sun A -- Punshon, Tracy -- Lanzirotti, Antonio -- Li, Liangtao -- Alonso, Jose M -- Ecker, Joseph R -- Kaplan, Jerry -- Guerinot, Mary Lou -- DK 30534/DK/NIDDK NIH HHS/ -- P42 ES07373/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2006 Nov 24;314(5803):1295-8. Epub 2006 Nov 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17082420" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/genetics/growth & development/*metabolism
;
Arabidopsis Proteins/genetics/*metabolism
;
Cation Transport Proteins/genetics/*metabolism
;
Cotyledon/chemistry
;
Homeostasis
;
Hypocotyl/chemistry
;
Image Processing, Computer-Assisted
;
Intracellular Membranes/metabolism
;
Iron/analysis/*metabolism
;
Manganese/analysis
;
Mutation
;
Plant Epidermis/chemistry
;
Plants, Genetically Modified
;
Recombinant Fusion Proteins/metabolism
;
Seedlings/growth & development
;
Seeds/chemistry/*metabolism
;
Tomography, X-Ray Computed
;
Vacuoles/chemistry/*metabolism
;
Zinc/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink