ISSN:
1572-901X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A new ligand, 1-(2-furanthiocarbo)-3-thiosemicarbazide (H2ftsc), prepared from thiosemicarbazide and carboxymethyl-2-furandithioate, forms complexes [Mn(ftsc)(H2O)2], [Pd(ftsc)] · 2H2O, [M(Hftsc)(acac)2] (M = CoIII or CrIII), [M(Hftsc)2(acac)] (M = MnIII or FeIII) and [Zn(Hftsc)2] · 2H2O, which were characterized by elemental analyses, magnetic susceptibility, i.r., electronic and n.m.r. spectral data. The Mössbauer spectra of [Fe(Hftsc)2(acac)] at 298 K and 80 K suggest the presence of high-spin iron(III) with an S = 5/2 state. In vivo and in vitro antitumour activity of the ligand and the complexes have been screened towards several tumour cell-lines.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007081218000
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