ISSN:
1432-1041
Keywords:
Key words Asthma
;
Salbutamol; dose response
;
dry powder inhalers
;
relative efficacy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: To investigate the relative efficacy of three inhalers containing salbutamol: Turbuhaler (TBH), Rotahaler (RH) and Diskhaler (DH). Methods: A randomized, open, three-way crossover, cumulative dose response study was performed in 20 patients with asthma with mean forced expiratory volume in 1s (FEV1) values of 60% of predicted (range 41–90%) and a 27% reversibility in FEV1 (range 15–61%). Four doses of salbutamol were inhaled at 30-min intervals: 50 μg, 50 μg, 100 μg and 200 μg by TBH and 200 μg, 200 μg, 400 μg and 800 μg by both RH and DH. FEV1 was measured at baseline and 25 min after each dose. Results: The increases in FEV1 after the first doses (50 μg by TBH, 200 μg by RH and by DH) were not statistically significantly different (23.6%, 25.1% and 28%, respectively). Based on the parallel shift in the dose response curves, salbutamol TBH was calculated to be 2.4 times as potent as salbutamol RH (95% confidence interval 1.4–3.3) and 2.2 times as potent as salbutamol DH (90% CI 1.3–3.3). Additionally, during dosing with TBH, fewer patients experienced adverse events than during dosing with RH or DH. Conclusion: Turbuhaler is a twofold more efficient inhaler for salbutamol than Rotahaler or Diskhaler as measured by its bronchodilating effect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050142
Permalink