ISSN:
0570-0833
Keywords:
Polymers
;
Solid-phase synthesis
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Polymeric reagents offer a range of unique advantages. Intramolecular reactions, such as the cyclization of peptides or Dieckmann cyclizations, can be brought about by attaching the reactive molecules at remote points along a polymer chain. In contrast, if the reactive molecules are anchored in close proximity on a polymeric support then intermolecular reactions occur, as demonstrated for a ketone synthesis. Apart from such proximity effects, cooperative effects can also be exploited, e.g. in the formation of a 2:1 complex of a crown ether and an alkali metal ion. The hydrolysis of an ester with polyvinylimidazole provides a detailed illustration of hydrophobic interactions. The simple separation of polymer-bound and low-molecular compounds by filtration is another significant advantage.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.197400991
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