ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Asymmetric cancer cell division regulated by AKT [Medical Sciences] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-08-03
    Description: Human tumors often contain slowly proliferating cancer cells that resist treatment, but we do not know precisely how these cells arise. We show that rapidly proliferating cancer cells can divide asymmetrically to produce slowly proliferating “G0-like” progeny that are enriched following chemotherapy in breast cancer patients. Asymmetric cancer cell division results from asymmetric suppression of AKT/PKB kinase signaling in one daughter cell during telophase of mitosis. Moreover, inhibition of AKT signaling with small-molecule drugs can induce asymmetric cancer cell division and the production of slow proliferators. Cancer cells therefore appear to continuously flux between symmetric and asymmetric division depending on the precise state of their AKT signaling network. This model may have significant implications for understanding how tumors grow, evade treatment, and recur.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Active Viscoelastic Matter: From Bacterial Drag Reduction to Turbulent Solids (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-03-06
    Description: Author(s): E. J. Hemingway, A. Maitra, S. Banerjee, M. C. Marchetti, S. Ramaswamy, S. M. Fielding, and M. E. Cates A paradigm for internally driven matter is the active nematic liquid crystal, whereby the equations of a conventional nematic are supplemented by a minimal active stress that violates time-reversal symmetry. In practice, active fluids may have not only liquid-crystalline but also viscoelastic polyme... [Phys. Rev. Lett. 114, 098302] Published Thu Mar 05, 2015
    Keywords: Polymer, Soft Matter, Biological, and Interdisciplinary Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Microwave-Osmotic Dehydration of Cranberries under Continuous Flow Medium Spray Conditions (2013)
    Hindawi
    Details
    Publication Date: 2013-02-21
    Description: Microwave-osmotic dehydration of cranberries was evaluated under continuous flow medium spray (MWODS) conditions after some pretreatments. A central composite rotatable design was used with three input variables at five levels (temperature, 33°C–67°C; sucrose concentration, 33°B–67°B; and contact time, 5–55 min). Responses were moisture loss (ML), solids gain (SG), and weight reduction (WR) as well as color and texture parameters. The responses were related to process variables using response surface methodology and statistical analysis: each model was tested for lack of fit to assure nonsignificance and each process variable was tested for significance . Temperature was found to have the most prominent effect as it was significant with all drying (ML, SG, and WR) and quality (hardness and chewiness) parameters, while contact time was found to be significant with ML and WR. Concentration wasn’t found to be significant for any response. Increasing skin pretreatment severity generally promoted SG but had little effect on ML. The exception was chemical peeling, which favored ML but had no effect on SG. Overall, MWODS enables food dehydration in a much faster period of time than conventional osmotic dehydration (COD), while specifically promoting moisture loss over solids gain.
    Print ISSN: 1687-5826
    Electronic ISSN: 1687-5834
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Hindawi
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Influence of System Variables on the Heating Characteristics of Water during Continuous Flow Microwave Heating (2012)
    Hindawi
    Details
    Publication Date: 2012-06-21
    Description: A domestic microwave oven (1000 W) was modified to permit the continuous flow of liquids run through a helical coil centrally located inside the oven cavity. Heating characteristics were evaluated by measuring inlet and outlet temperatures of coil as a function of system variables. The influence of number of turns, coil diameter, tube diameter, pitch and initial temperature were evaluated at different flow rates. The average residence time of water was computed by dividing the coil volume by the volumetric flow rate. The influence of Dean number was evaluated. Results from this study showed that (1) higher number of turns resulted in lower heating rate, lower temperature fluctuations, higher exit temperature and longer time to achieve temperature equilibrium; (2) larger tube or coil diameter gave larger coil volume causing the heating rate to decrease; (3) faster flow rates resulted in lower exit temperatures, lower temperature fluctuation, higher Dean number and slightly higher heating rate; (4) higher initial temperatures resulted in higher exit temperatures; (5) higher Dean number resulted in more uniform heating and slightly higher heating rate. Overall, the coil volume was the more dominant factor affecting heating rate as compared with flow rate and Dean number.
    Print ISSN: 1687-5826
    Electronic ISSN: 1687-5834
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Hindawi
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Optimization of Microwave-Osmotic Pretreatment of Apples with Subsequent Air-Drying for Preparing High-Quality Dried Product (2012)
    Hindawi
    Details
    Publication Date: 2012-06-21
    Description: Prepared apple (Red Gala) cylinders were subjected to microwave-osmotic dehydration treatment under continuous flow medium spray (MWODS) conditions and then air-dried to a final 20% moisture content. The dried samples were evaluated for color and textural properties, and rehydration capacity. The MWODS pretreatments were based on a central composite rotatable design and a response surface methodology using five levels of sucrose concentration, temperature, and contact time at a constant flow rate of 2800 mL/min. The air-drying was carried out at 60°C, 15±1% relative humidity, and 0.64±0.02 m/s air velocity. The results were compared to untreated air-dried (AD) (worst-case scenario) and freeze-dried (FD) (best-case scenario) apples without the MWODS treatment. Color properties were affected regardless of the type of treatment. Conventional AD apples were darker in color, whereas MWODS-treated samples were lighter with higher L∗ and b∗ values, higher Hue and Chroma values but lower a∗ value and ΔE. Further the color parameters of MWODS-treated samples were closer or equal to the FD apples. The texture properties were also affected by the osmotic variables with MWODS treatment resulting in softer and chewier products. The AD samples were hard, and FD apples were brittle.
    Print ISSN: 1687-5826
    Electronic ISSN: 1687-5834
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Hindawi
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Atomic-Resolution Structures of Horse Liver Alcohol Dehydrogenase with NAD+ and Fluoroalcohols Define Strained Michaelis Complexes (2012)
    American Chemical Society (ACS)
    Details
    Publication Date: 2012-05-02
    Description: Biochemistry DOI: 10.1021/bi300378n
    Print ISSN: 0006-2960
    Electronic ISSN: 1520-4995
    Topics: Biology , Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Causal inference methods to study nonrandomized, preexisting development interventions [Sustainability Science] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-01-04
    Description: Empirical measurement of interventions to address significant global health and development problems is necessary to ensure that resources are applied appropriately. Such intervention programs are often deployed at the group or community level. The gold standard design to measure the effectiveness of community-level interventions is the community-randomized trial, but the conditions of these trials often make it difficult to assess their external validity and sustainability. The sheer number of community interventions, relative to randomized studies, speaks to a need for rigorous observational methods to measure their impact. In this article, we use the potential outcomes model for causal inference to motivate a matched cohort design to study the impact and sustainability of nonrandomized, preexisting interventions. We illustrate the method using a sanitation mobilization, water supply, and hygiene intervention in rural India. In a matched sample of 25 villages, we enrolled 1,284 children
    Keywords: Sustainability Science
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Yeast Alcohol Dehydrogenase Structure and Catalysis (2014)
    American Chemical Society (ACS)
    Details
    Publication Date: 2014-09-05
    Description: Biochemistry DOI: 10.1021/bi5006442
    Print ISSN: 0006-2960
    Electronic ISSN: 1520-4995
    Topics: Biology , Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur cluster (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-01-29
    Description: Light generates reducing equivalents in chloroplasts that are used not only for carbon reduction, but also for the regulation of the activity of chloroplast enzymes by reduction of regulatory disulfides via the ferredoxin:thioredoxin reductase (FTR) system. FTR, the key electron/thiol transducer enzyme in this pathway, is unique in that it can reduce disulfides by an iron-sulfur cluster, a property that is explained by the tight contact of its active-site disulfide and the iron-sulfur center. The thin, flat FTR molecule makes the two-electron reduction possible by forming on one side a mixed disulfide with thioredoxin and by providing on the opposite side access to ferredoxin for delivering electrons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dai, S -- Schwendtmayer, C -- Schurmann, P -- Ramaswamy, S -- Eklund, H -- New York, N.Y. -- Science. 2000 Jan 28;287(5453):655-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, Biomedical Center, S-751 24 Uppsala, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10649999" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Catalytic Domain ; Chloroplasts/*metabolism ; Crystallography, X-Ray ; Cyanobacteria/*enzymology ; Cysteine/chemistry ; Dimerization ; Disulfides/chemistry/*metabolism ; Electron Transport ; Ferredoxins/metabolism ; Hydrogen Bonding ; Iron/chemistry ; Iron-Sulfur Proteins ; Models, Molecular ; Oxidation-Reduction ; Oxidoreductases/*chemistry/*metabolism ; Protein Structure, Secondary ; Signal Transduction ; Thioredoxins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-07-04
    Description: Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme. The "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the "Rieske" protein (subunit 9) is lodged between the two "core" subunits at the matrix side of the complex. These "core" subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iwata, S -- Lee, J W -- Okada, K -- Lee, J K -- Iwata, M -- Rasmussen, B -- Link, T A -- Ramaswamy, S -- Jap, B K -- New York, N.Y. -- Science. 1998 Jul 3;281(5373):64-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA. iwata@xray.bmc.uu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9651245" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Cattle ; Crystallization ; Crystallography, X-Ray ; Cytochrome b Group/chemistry/metabolism ; Cytochromes c1/chemistry/metabolism ; Electron Transport ; Electron Transport Complex III/*chemistry/metabolism ; Enzyme Inhibitors/metabolism ; Hydrogen Bonding ; Hydroquinones/metabolism ; Intracellular Membranes/enzymology ; Iron-Sulfur Proteins/chemistry/metabolism ; Methacrylates ; Mitochondria, Heart/*enzymology ; Models, Molecular ; Molecular Sequence Data ; Oxidation-Reduction ; *Protein Conformation ; Protein Structure, Secondary ; Thiazoles/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...