Publication Date:
2014-06-05
Description:
It has been proposed that memories are encoded by modification of synaptic strengths through cellular mechanisms such as long-term potentiation (LTP) and long-term depression (LTD). However, the causal link between these synaptic processes and memory has been difficult to demonstrate. Here we show that fear conditioning, a type of associative memory, can be inactivated and reactivated by LTD and LTP, respectively. We began by conditioning an animal to associate a foot shock with optogenetic stimulation of auditory inputs targeting the amygdala, a brain region known to be essential for fear conditioning. Subsequent optogenetic delivery of LTD conditioning to the auditory input inactivates memory of the shock. Then subsequent optogenetic delivery of LTP conditioning to the auditory input reactivates memory of the shock. Thus, we have engineered inactivation and reactivation of a memory using LTD and LTP, supporting a causal link between these synaptic processes and memory.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210354/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210354/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nabavi, Sadegh -- Fox, Rocky -- Proulx, Christophe D -- Lin, John Y -- Tsien, Roger Y -- Malinow, Roberto -- MH049159/MH/NIMH NIH HHS/ -- NS27177/NS/NINDS NIH HHS/ -- R01 AG032132/AG/NIA NIH HHS/ -- R01 MH049159/MH/NIMH NIH HHS/ -- R01 MH091119/MH/NIMH NIH HHS/ -- R01 NS027177/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2014 Jul 17;511(7509):348-52. doi: 10.1038/nature13294. Epub 2014 Jun 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Center for Neural Circuits and Behavior, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, California 92093, USA [2]. ; Center for Neural Circuits and Behavior, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, California 92093, USA. ; Department of Pharmacology, University of California at San Diego, California 92093, USA. ; 1] Department of Pharmacology, University of California at San Diego, California 92093, USA [2] Howard Hughes Medical Institute, University of California at San Diego, California 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24896183" target="_blank"〉PubMed〈/a〉
Keywords:
Amygdala/physiology
;
Animals
;
Conditioning (Psychology)/physiology
;
Electric Stimulation
;
Electrophysiology
;
Fear/physiology/psychology
;
Long-Term Potentiation/*physiology
;
Long-Term Synaptic Depression/*physiology
;
Male
;
Memory/*physiology
;
Optogenetics
;
Rats
;
Rats, Sprague-Dawley
;
Synapses/*physiology
;
Synaptic Transmission
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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