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  • 1
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    Soft electrode systems integrated on the auricle [Engineering] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-04-01
    Description: Recent advances in electrodes for noninvasive recording of electroencephalograms expand opportunities collecting such data for diagnosis of neurological disorders and brain–computer interfaces. Existing technologies, however, cannot be used effectively in continuous, uninterrupted modes for more than a few days due to irritation and irreversible degradation in the electrical and mechanical...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Sensors, Vol. 19, Pages 1000: Damage Detection Performance of the Electromechanical Impedance (EMI) Technique with Various Attachment Methods on Glass Fibre Composite Plates (2019)
    MDPI
    In: Sensors
    Details
    Publication Date: 2019
    Description: Composite materials such as glass and carbon fibre composites have become popular and the preferred choice in various applications due to their many advantages such as corrosion resistance, design flexibility, high strength and light weight. Combining materials with different mechanical properties make composites more difficult to evaluate where the damage mechanisms for composites are more complex than traditional materials such as steel. A relatively new non-destructive testing (NDT) method known as the electromechanical impedance (EMI) technique has been studied by various researchers, but the damage detection performance of the method on composite structures still requires more investigations before it can be accepted for field application, especially in aerospace industry due to the high standard of safety. In this paper, the detection capabilities and performance of the EMI technique subjected to different PZT attachment methods have been investigated. To this end, glass fibre composite plates with various attachment methods for the sensor have been prepared and detection of common defects such as delamination and crack with the EMI technique under study has been performed. The performance of each attachment method for identifying different damage types has been analysed and finite element analysis (FEA) was carried out for verification of the experimental results.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI
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  • 3
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    Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-06-24
    Description: T helper 1 (TH1) cells mediate cellular immunity, whereas TH2 cells potentiate antiparasite and humoral immunity. We used a complementary DNA subtraction method, representational display analysis, to show that the small guanosine triphosphatase Rac2 is expressed selectively in murine TH1 cells. Rac induces the interferon-gamma (IFN-gamma) promoter through cooperative activation of the nuclear factor kappa B and p38 mitogen-activated protein kinase pathways. Tetracycline-regulated transgenic mice expressing constitutively active Rac2 in T cells exhibited enhanced IFN-gamma production. Dominant-negative Rac inhibited IFN-gamma production in murine T cells. Moreover, T cells from Rac2-/- mice showed decreased IFN-gamma production under TH1 conditions in vitro. Thus, Rac2 activates TH1-specific signaling and IFN-gamma gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, B -- Yu, H -- Zheng, W -- Voll, R -- Na, S -- Roberts, A W -- Williams, D A -- Davis, R J -- Ghosh, S -- Flavell, R A -- New York, N.Y. -- Science. 2000 Jun 23;288(5474):2219-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520-8011, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10864872" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cells, Cultured ; Cytokines/biosynthesis/genetics ; Gene Expression Regulation ; Humans ; Interferon-gamma/biosynthesis/*genetics ; JNK Mitogen-Activated Protein Kinases ; Jurkat Cells ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Promoter Regions, Genetic ; Signal Transduction ; Th1 Cells/cytology/*immunology/*metabolism ; Transfection ; p38 Mitogen-Activated Protein Kinases ; rac GTP-Binding Proteins/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-06-17
    Description: Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine, an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces fast-acting antidepressant responses in patients suffering from major depressive disorder, although the underlying mechanism is unclear. Depressed patients report the alleviation of major depressive disorder symptoms within two hours of a single, low-dose intravenous infusion of ketamine, with effects lasting up to two weeks, unlike traditional antidepressants (serotonin re-uptake inhibitors), which take weeks to reach efficacy. This delay is a major drawback to current therapies for major depressive disorder and faster-acting antidepressants are needed, particularly for suicide-risk patients. The ability of ketamine to produce rapidly acting, long-lasting antidepressant responses in depressed patients provides a unique opportunity to investigate underlying cellular mechanisms. Here we show that ketamine and other NMDAR antagonists produce fast-acting behavioural antidepressant-like effects in mouse models, and that these effects depend on the rapid synthesis of brain-derived neurotrophic factor. We find that the ketamine-mediated blockade of NMDAR at rest deactivates eukaryotic elongation factor 2 (eEF2) kinase (also called CaMKIII), resulting in reduced eEF2 phosphorylation and de-suppression of translation of brain-derived neurotrophic factor. Furthermore, we find that inhibitors of eEF2 kinase induce fast-acting behavioural antidepressant-like effects. Our findings indicate that the regulation of protein synthesis by spontaneous neurotransmission may serve as a viable therapeutic target for the development of fast-acting antidepressants.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172695/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172695/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Autry, Anita E -- Adachi, Megumi -- Nosyreva, Elena -- Na, Elisa S -- Los, Maarten F -- Cheng, Peng-fei -- Kavalali, Ege T -- Monteggia, Lisa M -- MH066198/MH/NIMH NIH HHS/ -- MH070727/MH/NIMH NIH HHS/ -- R01 MH066198/MH/NIMH NIH HHS/ -- R01 MH066198-07/MH/NIMH NIH HHS/ -- R01 MH066198-08/MH/NIMH NIH HHS/ -- T32 MH 76690-02/MH/NIMH NIH HHS/ -- England -- Nature. 2011 Jun 15;475(7354):91-5. doi: 10.1038/nature10130.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9111, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21677641" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents/*pharmacology ; Behavior, Animal/drug effects/physiology ; Brain-Derived Neurotrophic Factor/biosynthesis/deficiency/genetics/pharmacology ; Depression/drug therapy ; Disease Models, Animal ; Dizocilpine Maleate/pharmacology ; Elongation Factor 2 Kinase/metabolism ; Gene Expression Regulation/drug effects ; Ketamine/*pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation/drug effects ; Piperazines/pharmacology ; Protein Biosynthesis/drug effects ; Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors/metabolism ; Rest/*physiology ; Suicide/prevention & control ; Synapses/drug effects/metabolism ; Synaptic Transmission/drug effects ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Sensors, Vol. 18, Pages 1307: A Review of the Piezoelectric Electromechanical Impedance Based Structural Health Monitoring Technique for Engineering Structures (2018)
    MDPI Publishing
    In: Sensors
    Details
    Publication Date: 2018-04-25
    Description: Sensors, Vol. 18, Pages 1307: A Review of the Piezoelectric Electromechanical Impedance Based Structural Health Monitoring Technique for Engineering Structures Sensors doi: 10.3390/s18051307 Authors: Wongi S. Na Jongdae Baek The birth of smart materials such as piezoelectric (PZT) transducers has aided in revolutionizing the field of structural health monitoring (SHM) based on non-destructive testing (NDT) methods. While a relatively new NDT method known as the electromechanical (EMI) technique has been investigated for more than two decades, there are still various problems that must be solved before it is applied to real structures. The technique, which has a significant potential to contribute to the creation of one of the most effective SHM systems, involves the use of a single PZT for exciting and sensing of the host structure. In this paper, studies applied for the past decade related to the EMI technique have been reviewed to understand its trend. In addition, new concepts and ideas proposed by various authors are also surveyed, and the paper concludes with a discussion of the potential directions for future works.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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  • 6
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    Sensors, Vol. 18, Pages 2267: Effects of Applying Different Resonance Amplitude on the Performance of the Impedance-Based Health Monitoring Technique Subjected to Damage (2018)
    MDPI Publishing
    In: Sensors
    Details
    Publication Date: 2018-07-14
    Description: Sensors, Vol. 18, Pages 2267: Effects of Applying Different Resonance Amplitude on the Performance of the Impedance-Based Health Monitoring Technique Subjected to Damage Sensors doi: 10.3390/s18072267 Authors: Wongi S. Na Dong-Woo Seo Byeong-Cheol Kim Ki-Tae Park Smart materials such as piezoelectric transducers can be used for monitoring the health of building structures. In this study, a structural health monitoring technique known as the electromechanical impedance (EMI) method is investigated. Although the EMI method has the advantage of using a single piezoelectric patch that acts both as the actuator and as the sensor, there are still many issues to be addressed. To further understand the problem, the performance of the EMI method on a structure subjected to progressive damage at different resonance frequency ranges and peak amplitudes was investigated using three different statistical metrics: root-mean-square deviation (RMSD), mean absolute percentage deviation (MAPD) and correlation coefficient deviation (CCD). Metal plates were used throughout the study. The results acquired could be used to further understand the damage identification performance of the EMI method.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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  • 7
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    A molecular mechanism for choosing alcohol over an alternative reward (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-06-22
    Description: Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which ~15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the -aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder.
    Keywords: Medicine, Diseases, Neuroscience
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells (2014)
    Springer Nature
    Details
    Publication Date: 2014-05-16
    Description: Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells Cell Death and Disease 5, e1224 (May 2014). doi:10.1038/cddis.2014.189 Authors: J Y Sung, S-Y Park, J H Kim, H G Kang, J H Yoon, Y S Na, Y-N Kim & B-K Park
    Keywords: ICSBPEMT-like phenomenaTGF-βSnailcell motilityinvasion
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 9
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    CK2 regulation by IP6 and Nopp140 [Biochemistry] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-11-27
    Description: Protein kinase CK2 is a ubiquitous kinase that can phosphorylate hundreds of cellular proteins and plays important roles in cell growth and development. Deregulation of CK2 is related to a variety of human cancers, and CK2 is regarded as a suppressor of apoptosis; therefore, it is a target of anticancer...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase (2015)
    Oxford University Press
    Details
    Publication Date: 2015-07-25
    Description: DNA double-strand breaks (DSBs) are the most severe type of DNA damage and are primarily repaired by non-homologous end joining (NHEJ) and homologous recombination (HR) in the G1 and S/G2 phase, respectively. Although CtBP-interacting protein (CtIP) is crucial in DNA end resection during HR following DSBs, little is known about how CtIP levels increase in an S phase-specific manner. Here, we show that Serpine mRNA binding protein 1 (SERBP1) regulates CtIP expression at the translational level in S phase. In response to camptothecin-mediated DNA DSBs, CHK1 and RPA2 phosphorylation, which are hallmarks of HR activation, was abrogated in SERBP1-depleted cells. We identified CtIP mRNA as a binding target of SERBP1 using RNA immunoprecipitation-coupled RNA sequencing, and confirmed SERBP1 binding to CtIP mRNA in S phase. SERBP1 depletion resulted in reduction of polysome-associated CtIP mRNA and concomitant loss of CtIP expression in S phase. These effects were reversed by reconstituting cells with wild-type SERBP1, but not by SERBP1 RGG, an RNA binding defective mutant, suggesting regulation of CtIP translation by SERBP1 association with CtIP mRNA. These results indicate that SERBP1 affects HR-mediated DNA repair in response to DNA DSBs by regulation of CtIP translation in S phase.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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